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Genes, Cells and Tissues

  • Module code: LS4001
  • Year: 2018/9
  • Level: 4
  • Credits: 30
  • Pre-requisites: Appropriate Level 3 Science qualification
  • Co-requisites: None

Summary

This module is a core module taken by students studying Biochemistry, Biological Sciences, Biomedical Science, Forensic Science, and Pharmacology. The module introduces students to basic cell biology of prokaryotes and eukaryotes, molecular, organismal and population genetics, germ layers and basic tissue types in the human body, and to a variety of microorganisms. Core information is provided in lectures and supported by material on Canvas. Laboratory practicals give students the opportunity to learn a selection of current techniques used to study cells, tissues, chromosomes and microbes. The module provides a solid foundation for subsequent modules at levels 5 and 6 that expand knowledge in cell biology, anatomy, physiology, genetics and microbiology.

Aims

  • To provide a knowledge and understanding of basic cell biology and genetic processes
  • To provide a knowledge and understanding of basic concepts in Mendelian genetics, population and evolutionary genetics and molecular techniques
  • To develop a knowledge and understanding of embryonic and adult tissues
  • To develop a knowledge and understanding of microorganisms
  • To introduce a selection of current techniques in light microscopy, histology, cytogenetics and microbiology

Learning outcomes

On successful completion of the module, students will be able to:

  • demonstrate an understanding of the major cell components and discuss their functions in prokaryotic and eukaryotic cells;
  • demonstrate an understanding of basic concepts in molecular, population and evolutionary genetics;
  • perform simple calculations relating to inheritance and population genetics;
  • display a basic knowledge of the early development, structure and functions of major tissue types in the human body;
  • recognize and discuss the characteristics of a variety of medically important microorganisms;
  • demonstrate a comprehension of selected current techniques in light microscopy, histology, cytogenetics, and microbiology.

Curriculum content

  • basic preparative techniques for examination of biological specimens by light microscopy and correct use of light microscopes
  • an introduction to the origins of life, cell structure and function of organelles in prokaryotic and eukaryotic cells
  • an introduction to genes, genomes and chromosomes
  • a review of the genetic processes in cells including DNA structure, replication, transcription and translation
  • an introduction to patterns of inheritance, Mendelian genetics, population and evolutionary genetics, basic calculations in inheritance and population genetics
  • an introduction to genetic recombination and mapping
  • an introduction to cytogenetics
  • an introduction to modern molecular techniques including cloning, recombinant DNA technology and DNA analysis
  • an introduction to early human development
  • structural and functional characteristics of epithelium, connective tissues, muscle and nervous tissues and their subtypes
  • an introduction to viruses, bacteria and microbial eukaryotes of medical importance
  • basic microbiological techniques

Teaching and learning strategy

Core concepts in cell and molecular biology, focussing on genes, cells and tissues, are discussed in research-led lectures by the module team who will direct the students to pre-sessional and further reading and additional educational on-line resources available on Canvas to support their learning. The closing lectures on molecular techniques will also inform students about career possibilities in the molecular science jobs market and current technical competencies required. These lectures will emphasise employability skills and the importance of accessing the University careers service.

Students will undertake four laboratory practicals on microscopy, histology, cytogenetics and microbiology to enable them to develop practical skills in the correct use of microscopes, examining and studying chromosomes, prokaryotic and eukaryotic cells and tissues,  interpreting and recording biological data, and build upon knowledge gained from lectures.  Students will be prepared for each practical by lectures, in combination with complementary on-line resources. 

Technology Enhanced Learning (TEL) is scheduled throughout the module to enable students to practice application of information and extend their knowledge.  These resources include video tutorials on microscopy, histological techniques and microbiology and on-line interactive tutorials and activities. Engagement by students with TEL sessions will be monitored via Canvas.

Overall, the blended learning approach adopted on this module encourages the expansion of knowledge in cell and molecular biology, tissues, microorganisms and associated techniques. The development of key skills, particularly self-awareness skills, in managing learning, communication, numeracy and literacy are facilitated. Valuable employability skills such as confidence building, identification of skills and competencies gained, self-reflection, awareness of career possibilities, the use of the careers service and giving and receiving feedback are embedded throughout the teaching, learning and assessment strategies in this module.

Breakdown of Teaching and Learning Hours

Definitive UNISTATS Category Indicative Description Hours
Scheduled learning and teaching Lectures and seminars (46 h) 4 x 3 hour practicals (12 h) Scheduled technology enhanced learning (21 h) 79
Guided independent study Directed reading, use of video tutorials, interactive electronic study packages and formative question banks. 221
Total (number of credits x 10) 300

Assessment strategy

The module is summatively assessed through a portfolio of small practical MCQ tests (30%), an in-class essay assignment (30%) and an end-of-year examination (40%).

The portfolio of tests consists of three separate, short on-line tests (each worth 10%) of knowledge, techniques and outcomes relating to laboratory classes. A formative test of the first laboratory class allows students to familiarise themselves with the format of the summative tests and to assess their own progress with immediate feedback.  Students are eligible to submit the assessments if they have attended the relevant practical sessions.  These coursework assessments test the understanding of practical techniques, encourage further reading and provide an opportunity for reflection of skills acquisition.  Individual electronic feedback will be supplied to each student after submission.

The in-class essay assignment requires students to answer short essays under examination conditions, the titles of which are given in advance.  The essays are designed to test the understanding of the core concepts covered by pre-sessional reading, discussed in lectures and further developed in directed further reading.  Answers are peer-marked with guidance from the lecturer who provides a marking scheme. Students gain an understanding of the depth of knowledge required for this stage of their degree and acquire experience in applying their knowledge and assess their progress in learning. Students benefit from this opportunity to develop their literacy skills in preparation for the end of module examinations and beyond.

The end of module examination (40%) will test student knowledge and understanding of module content that has not been assessed by the essay assignment..

Regular and detailed feedback is provided to students by formative assessments such as practice MCQ tests undertaken during lectures, and through an extensive range of formative question banks available on Canvas. This formative feedback will facilitate students to test their understanding of theoretical and practical concepts, organize their own learning, self-reflect on their progress and encourage regular revision for summative assessments. Post-examination generic feedback will be posted on Canvas and the module team will be available in term-time to give personal feedback to students on their examination performance.

Mapping of Learning Outcomes to Assessment Strategy (Indicative)

Learning Outcome Assessment Strategy
1) Demonstrate an understanding of the major cell components and discuss their functions in prokaryotic and eukaryotic cells. Formal examination (S), essay assignment (S) and practice answers in lectures/TEL (F).
2) Demonstrate an understanding of basic concepts in molecular, population and evolutionary genetics. Formal examination (S), essay assignment (S) and practice answers/TEL (F).
3) Perform simple calculations relating to inheritance and population genetics. Formal examination (S), essay assignment (S) and practice answers/TEL (F).
4) Display a basic knowledge of the early development and structure and functions of major tissue types in the human body. Formal examination (S), practical MCQ portfolio (S), essay assignment (S) and practice answers/TEL (F).
5) Recognize and discuss the characteristics of a variety of medically important microorganisms. Formal examination (S), practical MCQ portfolio (S), essay assignment (S) and practice answers/TEL (F).
6) Demonstrate a comprehension of selected current techniques in light microscopy, histology, cytogenetics, and microbiology. Practical MCQ portfolio (S).

Elements of Assessment

Description of Assessment Definitive UNISTATS Categories Percentage
Formal end-of-year examination Written Exam 40%
Essay assignment Written Exam 30%
Portfolio of on-line tests Coursework 30%
Total (to equal 100%) 100%

Achieving a pass

It IS NOT a requirement that any major element of assessment is passed separately in order to achieve an overall pass for the module.

Bibliography core texts

The current edition of the following:

Sadava, D., Hillis, D.M., Heller, H.C. and Berenbaum, M.R. Life: The Science of Biology. Tenth Edition. Sinauer Associates Inc. W.H. Freeman and Co.

Bibliography recommended reading

Alberts, B., Bray, D., Hopkin, K., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. Essential Cell Biology. Fourth Edition. Garland Science.

Madigan, M.T., Martinko, J.M., Stahl, D.A. and Clark, D.P.  Brock Biology of Microorganisms. Pearson.

Marieb, E.N. and Hoehn, K. Human Anatomy and Physiology. Pearson.

Nelson, D. and Cox, M. Lehninger Principles of Biochemistry. W.H. Freeman.

Russell, P.J. iGenetics: a Molecular Approach.  Pearson.

Young, B., O'Dowd, G. and Woodford, P. Wheater's Functional Histology: a text and colour atlas. Churchill Livingstone.

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