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Dr Mark Preece

Course director and senior lecturer in physiology and pharmacology, School of Life Sciences, Kingston University.

Dr Mark Preece Areas of expertise

Find out more about Dr Mark Preece

Overview

Mark is a neuropharmacologist by training, studying the effects of drugs upon the body's nervous system.  His areas of interest extend to drugs used to treat conditions such as schizophrenia, anxiety and depression, drugs of abuse and the methods used to study these drugs.  Paramount amongst these methods is the use of functional magnetic resonance imaging (or fMRI) in brain imaging studies, a technique which Mark has contributed to the validation of in the development of new drugs for the treatment of mental illness.  Mark is also very active in the field of public engagement in science, having amongst other activities, established the Kingston upon Thames branch of Cafe Scientifique. This monthly informal social gathering allows academics from the University to share their work and expertise with a wider more general audience. In addition Mark heads the public engagement group within the Faculty of Science, Engineering and Computing at the University.

 

 

 

Qualifications

Year gained Subject
1998 PhD in neuropharmacology (CNS modulation of the baroreceptor reflex), Monash University, Victoria, Australia.
1990 BSC (Hons.) in biology sciences, North East Surrey College of Technology, Surrey.

Career Highlights

Year Position held
2006 - Course director and senior lecturer in physiology and pharmacology, School of Life Sciences, Kingston University.
2004 - 2006 Senior lecturer and programmes co-ordinator, McTimoney College of Chiropractic, Oxfordshire.
2002 - 2004 Postdoc research associate, Department of Pharmacology, University of Oxford.
2001 - 2002 Postdoc research associate, Department of Biomedical Sciences, University of Sheffield.
1998 - 2000 Postdoc research associate, Herchel Smith Laboratory, University of Cambridge.
1991 - 1993 Research neuropharmacologist, Wyeth Research.
1985 - 1991 Scientific officer, Royal Air Force Institute of Aviation Medicine.

Research

Papers:

Preece, MA, Taylor, MJ, Raley, J, Blamire, A, Sharp, T and Sibson, NR (2009) Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependant functional magnetic resonance imaging response in the rat brain. Neuroscience, 159, 751-759.

Preece, M.A., Sibson, N.R., Raley, J.M., Blamire, A., Styles, P. and Sharp, T.  (2007) Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brain.  Synapse, 61, 925-932.

Mukherjee, B., Preece, M., Houston, G.C., Papadakis, N.G., Carpenter, T.A., Hall, L.D. and Huang, C.L.  (2005)  Mapping of the cerebral response to acetazolamide using graded asymmetric spin echo EPI.  Magn. Reson. Imaging, 23, 907-920.

Preece, M.A., Dalley, J.W., Theobald, D.E., Robbins, T.W. and Reynolds, G.P.  (2004) Region specific changes in forebrain 5-HT1A and 5-HT2A receptors in isolation-reared rats: an in vitro autoradiography study.  Neuroscience, 123, 725-732.

Powell, S.B., Geyer, M.A., Preece, M.A., Pitcher, L.K., Reynolds, G.P. and Swerdlow, N.R.  (2003)  Dopamine depletion of the nucleus accumbens reverses isolation induced deficits in prepulse inhibition in rats.  Neuroscience, 119, 233-240.

Preece, M., Mukherjee, B., Huang, C. L-H., Hall, L.D., Leslie, R.A. and James, M.F.  (2001)  Detection of pharmacologically mediated changes in cerebral activity by functional magnetic resonance imaging: the effects of sulpiride in the brain of the anaesthetised rat.  Brain Res., 916, 107-114.

Ashworth-Preece, M.A., Chen, F., Jarrott, B and Lawrence, A.J.  (1999)  Visualisation of AMPA binding sites in the brain stem of normotensive and hypertensive rats.  Brain Res., 834, 186-189.

Ashworth-Preece, M.A., Jarrott, B and Lawrence, A.J.  (1998)  Nicotinic acetylcholine receptor mediated modulation of evoked excitatory amino acid release in the nucleus tractus solitarius of the rat: evidence from in vivo microdialysis.  Brain Res., 806, 287-291.

Ashworth-Preece, M., Jarrott, B and Lawrence, A.J.  (1998)  Nicotinic acetylcholine receptors in the rat and primate nucleus tractus solitarius and on rat and human inferior vagal (nodose) ganglia: evidence from in vivo microdialysis and [125I]-bungarotoxin autoradiography.  Neuroscience, 83, 1113-1122.

Ashworth-Preece, M., Krstew, E., Jarrott, B. and Lawrence, A.J.  (1997)  Functional GABAA receptors on rat vagal afferent neurones.  Br. J. Pharmacol., 120, 469-475.

Ashworth-Preece, M., Jarrott, B. and Lawrence, A.J.  (1995)  5-Hydroxytryptamine3 receptor modulation of excitatory amino acid release in the rat nucleus tractus solitarius.  Neurosci. Lett., 191, 75-78.

Routledge, C., Gurling, J., Ashworth-Preece, M.A. and Dourish, C.T.  (1995)  Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190.  Eur. J. Pharmacol., 276, 281-284.

Routledge, C., Hartley, J., Gurling, J., Ashworth-Preece, M.A., Brown, G. and Dourish, C.T.  (1994)  In vivo characterisation of the putative 5-HT1A receptor antagonist SDZ 216,525 using two models of somatodendritic 5-HT1A receptor function.  Neuropharmacology, 33, 359-366.

Professional Body Membership

British Pharmacological Society

 

Contact us

General enquiries:

Journalists only:

  • Communications team
    Tel: +44 (0)20 8417 3034
    Email us

Contact us

General enquiries:

Journalists only:

  • Communications team
    Tel: +44 (0)20 8417 3034
    Email us
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