Course director and senior lecturer in physiology and pharmacology, School of Life Sciences, Kingston University.
Mark is a neuropharmacologist by training, studying the effects of drugs upon the body's nervous system. His areas of interest extend to drugs used to treat conditions such as schizophrenia, anxiety and depression, drugs of abuse and the methods used to study these drugs. Paramount amongst these methods is the use of functional magnetic resonance imaging (or fMRI) in brain imaging studies, a technique which Mark has contributed to the validation of in the development of new drugs for the treatment of mental illness. Mark is also very active in the field of public engagement in science, having amongst other activities, established the Kingston upon Thames branch of Cafe Scientifique. This monthly informal social gathering allows academics from the University to share their work and expertise with a wider more general audience. In addition Mark heads the public engagement group within the Faculty of Science, Engineering and Computing at the University.
|1998||PhD in neuropharmacology (CNS modulation of the baroreceptor reflex), Monash University, Victoria, Australia.|
|1990||BSC (Hons.) in biology sciences, North East Surrey College of Technology, Surrey.|
|2006 -||Course director and senior lecturer in physiology and pharmacology, School of Life Sciences, Kingston University.|
|2004 - 2006||Senior lecturer and programmes co-ordinator, McTimoney College of Chiropractic, Oxfordshire.|
|2002 - 2004||Postdoc research associate, Department of Pharmacology, University of Oxford.|
|2001 - 2002||Postdoc research associate, Department of Biomedical Sciences, University of Sheffield.|
|1998 - 2000||Postdoc research associate, Herchel Smith Laboratory, University of Cambridge.|
|1991 - 1993||Research neuropharmacologist, Wyeth Research.|
|1985 - 1991||Scientific officer, Royal Air Force Institute of Aviation Medicine.|
Preece, MA, Taylor, MJ, Raley, J, Blamire, A, Sharp, T and Sibson, NR (2009) Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependant functional magnetic resonance imaging response in the rat brain. Neuroscience, 159, 751-759.
Preece, M.A., Sibson, N.R., Raley, J.M., Blamire, A., Styles, P. and Sharp, T. (2007) Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brain. Synapse, 61, 925-932.
Mukherjee, B., Preece, M., Houston, G.C., Papadakis, N.G., Carpenter, T.A., Hall, L.D. and Huang, C.L. (2005) Mapping of the cerebral response to acetazolamide using graded asymmetric spin echo EPI. Magn. Reson. Imaging, 23, 907-920.
Preece, M.A., Dalley, J.W., Theobald, D.E., Robbins, T.W. and Reynolds, G.P. (2004) Region specific changes in forebrain 5-HT1A and 5-HT2A receptors in isolation-reared rats: an in vitro autoradiography study. Neuroscience, 123, 725-732.
Powell, S.B., Geyer, M.A., Preece, M.A., Pitcher, L.K., Reynolds, G.P. and Swerdlow, N.R. (2003) Dopamine depletion of the nucleus accumbens reverses isolation induced deficits in prepulse inhibition in rats. Neuroscience, 119, 233-240.
Preece, M., Mukherjee, B., Huang, C. L-H., Hall, L.D., Leslie, R.A. and James, M.F. (2001) Detection of pharmacologically mediated changes in cerebral activity by functional magnetic resonance imaging: the effects of sulpiride in the brain of the anaesthetised rat. Brain Res., 916, 107-114.
Ashworth-Preece, M.A., Chen, F., Jarrott, B and Lawrence, A.J. (1999) Visualisation of AMPA binding sites in the brain stem of normotensive and hypertensive rats. Brain Res., 834, 186-189.
Ashworth-Preece, M.A., Jarrott, B and Lawrence, A.J. (1998) Nicotinic acetylcholine receptor mediated modulation of evoked excitatory amino acid release in the nucleus tractus solitarius of the rat: evidence from in vivo microdialysis. Brain Res., 806, 287-291.
Ashworth-Preece, M., Jarrott, B and Lawrence, A.J. (1998) Nicotinic acetylcholine receptors in the rat and primate nucleus tractus solitarius and on rat and human inferior vagal (nodose) ganglia: evidence from in vivo microdialysis and [125I]-bungarotoxin autoradiography. Neuroscience, 83, 1113-1122.
Ashworth-Preece, M., Krstew, E., Jarrott, B. and Lawrence, A.J. (1997) Functional GABAA receptors on rat vagal afferent neurones. Br. J. Pharmacol., 120, 469-475.
Ashworth-Preece, M., Jarrott, B. and Lawrence, A.J. (1995) 5-Hydroxytryptamine3 receptor modulation of excitatory amino acid release in the rat nucleus tractus solitarius. Neurosci. Lett., 191, 75-78.
Routledge, C., Gurling, J., Ashworth-Preece, M.A. and Dourish, C.T. (1995) Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. Eur. J. Pharmacol., 276, 281-284.
Routledge, C., Hartley, J., Gurling, J., Ashworth-Preece, M.A., Brown, G. and Dourish, C.T. (1994) In vivo characterisation of the putative 5-HT1A receptor antagonist SDZ 216,525 using two models of somatodendritic 5-HT1A receptor function. Neuropharmacology, 33, 359-366.
British Pharmacological Society