Senior lecturer in Physiology and Pharmacology, Kingston University
Dr Carew is a senior lecturer in physiology and pharmacolgy at Kingston University. As a lecturer, he teaches students physiology and pharmacology, which is how the body works, and how drugs work in the body. Most of the students he teaches are studying to be pharmacists, and they need a comprehensive grasp of both subjects in order to understand how and why medicines are used. Part of his teaching involves using computer simulations of the body, and he is always developing new scenarios in which students test their understanding of physiology.
As a research scientist, he investigates how cells work, and respond to different stimuli, either as part of their normal function, or in response to drugs that might be developed as new medicines. This involves studying how the many different components of intracellular signalling pathways (receptors, ion channels, enzymes, small messenger molecules and ions) are coordinated to produce cellular responses. For example, in the past, he has studied how cells use ion channels that pass chloride ions to produce a fluid secretion important in lung and gut function, and important in diseases such as cystic fibrosis.
His most recent research is on how cancer cells, and other cells growing out of control, respond to phytochemicals (drugs from plants) with reduced growth. One drug in particular, naringenin (from citrus fruits and other plants), is of interest because in laboratory tests it suppressed the growth of kidney cells forming fluid-filled cysts. The cyst model was used to study aspects of polycystic kidney disease, and now represents a coming together of all his interests: cell signalling, cell growth and the actions of phytochemicals.
|1995||PhD in cell physiology, Cambridge University.|
|1991||BSc (Hons) Biochemistry with Physiology, King's College, London.|
|2007 -||Senior lecturer in Physiology and Pharmacology, Kingston University.|
|2005 - 2007||Lecturer in Physiology and Pharmacology, Kingston University.|
|2002 - 2005||Freelance medical/science writer.|
|2000 - 2002||Medical writer, Ethical Strategies Ltd, Kingston upon Thames.|
|1998 - 2000||NIH Research Fellow, National Institute of Environmental Health Sciences, North Carolina.|
|1995 - 1998||MRC Research Fellow, Department of Cell Physiology, Babraham Institute and Department of Pharmacology, University of Cambridge.|
Waheed A, Ludtmann M, Pakes N, Robery S, Kuspa A, Dinh C, Baines D, Williams R, Carew MA. Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner. British Journal of Pharmacology 2013 doi:10.1111/bph.12443
Polycarpou E, Meira L, Carrington S, Tyrrell E, Modjtahedi H, Carew MA. Resveratrol 3-O-D-glucuronide and resveratrol 4'-O-D-glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion and G1 cell cycle arrest. Molecular Nutrition and Food Research 2013 Epub ahead of print May 7.
Brawn P, Tyrrell E, Carew M, Tesfa KH, Greenwood I (2012) A highly diastereoselective series of Nicholas cyclisation reactions of N-Boc-protected propargylamines. Tetrahedron 68: 10040-10048.
Waheed A, Barker J, Barton SJ, Owen CP, Ahmed S, Carew MA (2012). A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells. European Journal of Pharmaceutical Sciences. 29;47(2):464-73.
Young JS, Matharu R, Carew MA, Fry CH (2012). Inhibition of stretching-evoked ATP release from bladder mucosa by anticholinergic agents. British Journal of Urology International. 110(8 Pt B):E397-401
Waheed A, Barker J, Barton SJ, Khan G-M, Najm-Us-Saqib Q, Hussain M, Ahmed S, Owen C, Carew MA (2011). Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells. Journal of Ethnopharmacology, 137(3):1189-96.
Tyrrell E, Brawn P, Carew MA, Greenwood I (2011) An expedient conversion of alpha-amino acids into Weinreb amides using COMU (R) as a coupling agent. Tetrahedron Letters, 52(3), pp. 369-372.
Ganbold M, Barker J, Ma R, Jones L, Carew MA (2010) Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. Journal of Ethnopharmacology, 131(2), pp. 396-403.
Pedrosa Ribeiro CM, Paradiso AM, Carew MA, Shears SB. Boucher RC (2005) Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia. Journal of Biological Chemistry, 280(11), pp. 10202-10209. ISSN (print) 0021-9258
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB (2002) Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase. Curr Biol. 12(6):477-82.
Carew MA, Yang X, Schultz C, Shears SB (2000) myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line. J Biol Chem. 2000;275(35):26906-13.
Carew MA, Thorn P (2000) Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E2 release. Exp Physiol;85(1):67-72.
Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, Shears SB (1999). Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem;274(27):18973-80.
Ferguson AV, Bicknell RJ, Carew MA, Mason WT (1997) Dissociated adult rat subfornical organ neurons maintain membrane properties and angiotensin responsiveness for up to 6 days. Neuroendocrinology; 66(6):409-15.
Carew MA, Thorn P (1996). Identification of ClC-2-like chloride currents in pig pancreatic acinar cells. Pflugers Arch; 433(1-2):84-90.
Carew MA, Mason WT (1995). Control of Ca2+ entry into rat lactotrophs by thyrotrophin-releasing hormone. J Physiol;486 (Pt 2):349-60.
Carew MA, Wu ML, Law GJ, Tseng YZ, Mason WT (1994) Extracellular ATP activates calcium entry and mobilization via P2U-purinoceptors in rat lactotrophs. Cell Calcium;16(3):227-35.
Carew MA, Paleolog EM, Pearson JD (1992) The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells. Biochem J;286 (Pt 2):631-5.
Paleolog EM, Carew MA, Pearson JD (1991) Effects of tumour necrosis factor and interleukin-1 on von Willebrand factor secretion from human vascular endothelial cells. Int J Radiat Biol; 60(1-2):279-85.
Mason WT, Hoyland J, Davison I, Carew MA, Somasundarum B, Tregear R, Zorec R, Lledo PM, Shankar G, Horton GM. Quantitative real-time imaging of optical probes in living cells. In: Fluorescent and Luminescent Probes for Biological Activity, ed. Mason WT; Academic Press, 1993.
Mason WT, Hoyland J, Davison I, Carew MA, Jonasson J, Zorec R, Lledo P-M, Shankar G, Horton M. Technology for real-time fluorescent ratio imaging in living cells using fluorescent probes for ions. In: Molecular Imaging and Neuroscience, ed. Sharif N; Oxford University Press, UK, 1993.