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Dr Athina-Myrto (Myrto) Chioni

Senior Lecturer

About

I have completed my undergraduate degree in Biology from Imperial College London and I have obtained my MSc in Molecular Medicine in 2001 and my PhD in cell and molecular biology from Imperial College London where I was awarded the Imperial College Marshall Scholarship (annual award for research in Biology) and the A.G. Leventis Foundation Studentship. During my doctoral studies I investigated the expression of Voltage-gated sodium channels in human breast cancer cell lines in relation to metastatic potential. Upon completion of my PhD in 2006, I joined Barts and The London School of Medicine and Dentistry, QMUL (Institute of Cancer, Centre for Tumour Biology) in order to conduct postdoctoral research investigating the role of fibroblast growth factor (FGF) signalling in organogenesis, epithelial development, tissue repair and cancer. During my academic career, I have presented my work at a number of key conferences and meetings in the field of cancer research. During this time I had the great honour to receive a number of very prestigious awards, including; the Papanikolau first prize award (Hellenic Medical Society of Great Britain) and the first prize for an oral scientific presentation at Sylvia Lawler meeting (Royal Society of Medicine) in 2011 and 2012. Other awards include the William Harvey day 'Barts and The London' Poster presentation award in 2008 and 2011, junk the jargon competition at QMUL (1st prize winner) in 2011, 1st prize for an oral presentation at Barts and Queen Mary Science Festival in 2012, Poster presentation award at Gordon Conference 'Fibroblast Growth Factors in Development & Disease' in 2012. I have also been awarded twice a three year Breast Cancer campaign project grant as a named researcher in 2009 and 2013. In September 2014 I joined the School of Science as a Lecturer in Biomedical Sciences at Kingston University and in 2016 I became a Senior Lecturer in Biomedical Sciences and deputy course director BSc BMS.

Areas of specialism

  • Cell Biology
  • Molecular Biology
  • Cancer Biology
  • Tissue Culture
  • 3D organotypic models
  • Microscopy
  • Biomedical Sciences

Qualifications

  • Fellow of the Higher Education Academy (2015)
  • Associate Fellow of the Higher Education Academy (2015)
  • Postdoctoral Research Fellow at Queen Mary University of London, Barts Cancer Institute, Department of Tumour Biology (2006-214)
  • PhD Imperial College London (2003-2006)
  • MSc Molecular Medicine, Imperial College London (2001-2002)
  • BSc (Hons) Biology, Imperial College London (1998-2001)

Research

My principal research interests focus on fibroblast growth factor (FGF) signalling in cancer. The FGF receptor (FGFR) signalling pathway is implicated in a wide range of pathologies, most notably cancer, yet its efficient targeting is proving challenging to the pharmaceutical industry, partly because FGFR signalling is fundamental to so many normal biological processes. My previous research demonstrated that FGFR in breast cancer can get cleaved and translocate into the nucleus of the cells acting as a potential transcription factor that can alter metastatic cell behaviour. Previous studies have also demonstrated the presence of full length nuclear FGFR but never the cleaved form of the receptor. Targeting this novel aspect of FGFR signalling might represent a novel therapeutic approach in blocking cancer invasion.

Publications

Jump to: Article
Number of items: 9.

Article

Yeste-Velasco, Marc, Mao, Xueying, Grose, Richard, Kudahetti, Sakunthala C, Lin, Dongmei, Marzec, Jacek, Vasiljevic, Natasa, Chaplin, Tracy, Xue, Liyan, Xu, Maojia, Foster, Julie M, Karnam, Santi S, James, Sharon Y, Chioni, Athina-Myrto, Gould, David, Lorincz, Attila T, Oliver, R Tim D, Chelala, Claude, Thomas, Gareth M, Shipley, Janet M, Mather, Stephen J, Berney, Daniel M, Young, Bryan D and Lu, Yong-Jie (2014) Identification of ZDHHC14 as a novel human tumour suppressor gene. The Journal of Pathology, 232(5), pp. 566-577. ISSN (print) 0022-3417

Coleman, Stacey J, Chioni, Athina-Myrto, Ghallab, Mohammed, Anderson, Rhys K, Lemoine, Nicholas R, Kocher, Hemant M and Grose, Ricahrd P (2014) Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. EMBO Molecular Medicine, 6(4), pp. 467-481. ISSN (print) 1757-4676

Coleman, Stacey J., Bruce, Charo, Chioni, Athina‑Myrto, Kocher, Hemant M. and Grose, Richard P. (2014) The ins and outs of fibroblast growth factor receptor signalling. Clinical Science, 127(4), pp. 217-231. ISSN (print) 0143-5221

Chioni, Athina-Myrto and Grose, Richard (2012) FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. The Journal of Cell Biology (JCB), 197(6), pp. 801-817. ISSN (print) 0021-9525

Jarosz, Monika, Robbez-Masson, Luisa, Chioni, Athina-Myrto, Cross, Barbara, Rosewell, Ian and Grose, Richard (2012) Fibroblast Growth Factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS ONE, 7(6), e39436. ISSN (online) 1932-6203

Chioni, Athina-Myrto, Shao, Dongmin, Grose, Richard and Djamgoz, Mustafa B.A. (2010) Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: Activity-dependent positive feedback and cellular migration. The International Journal of Biochemistry & Cell Biology, 42(2), pp. 346-358. ISSN (print) 1357-2725

Chioni, Athina-Myrto and Grose, Richard (2009) Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3). European Journal of Cell Biology, 88(7), pp. 371-384. ISSN (print) 0171-9335

Chioni, Athina-Myrto, Brackenbury, William J., Calhoun, Jeffrey D., Isom, Lori L. and Djamgoz, Mustafa B.A. (2009) A novel adhesion molecule in human breast cancer cells: Voltage-gated Na[sup]+ channel [beta]1 subunit. The International Journal of Biochemistry & Cell Biology, 41(5), pp. 1216-1227. ISSN (print) 1357-2725

Chioni, Athina-Myrto and Grose, Richard (2008) Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis. Fibrogenesis & Tissue Repair, 1(1), p. 8. ISSN (online) 1755-1536

This list was generated on Sun Nov 19 04:50:11 2017 GMT.
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