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Dr Hossein Ashrafi

Associate Professor in Pathology/Cancer Biology

About

I received my PhD from Beatson Institute for Cancer Research, University of Glasgow in 1998 where I worked on viral causes of cancer. In the same year I was offered a postdoctoral fellowship in the Medical Oncology Laboratory at Glasgow University's Medical School, I was awarded a Royal Society Developing World Study Visit fellowship for distinguished postdoctoral work on relationship between papillomavirus and immune response.

I joined Kingston University, London in 2009 where I currently am an Associate Professor / Reader in Pathology, Course Leader for MSc Cancer Biology, fellow of Institute of Biomedical Science (IBMS), Fellow of Higher Education (FHEA). I teach on a range of Medical Science modules, supervise PhD research students, and lead an active research group on the interactions between the human host, viral pathogen and cancer, and also therapeutic approaches toward Human Papillomavirus (HPV) related cancers.

Areas of specialism

  • Cancer Biology
  • HPV and Cancer
  • Pathology

Qualifications

  • PhD in Pathology/Cancer Biology – Beatson Institute for Cancer Research, Faculty of Medicine, University of Glasgow
  • Postgraduate Certificate in Learning and Teaching in Higher Education, Kingston University London
  • DVM, University of Tehran. This is a professional doctorate degree together with one year research

Professional membership

ellow of the Institute of Biomedical Science 

Fellow of the Higher Education Academy (UK) 

Research

I have several goals to accomplish in the near future and some long term. I currently lead an active research programme with focus on the following subjects below:

1) Association of Human Papillomavirus (HPV) and Breast and Cervical Cancers

2) Therapeutic approaches (using natural products) toward Human Papillomavirus (HPV) related cancers

3) Association of human papillomavirus (HPV) and Urinary system cancers (Prostate, Bladder and Renal) 

4) Mechanisms of host immunomodulation by Papillomavirus and  Varizella-Zoster-Virus (VZV)

Publications

Number of items: 24.

Article

Salman, Nadia Aziz, Davies, Giles, Majidy, Farida, Shakir, Fatima, Akinrinade, Hilda, Perumal, Dhayaneethie and Ashrafi, G. Hossein (2017) Association of high risk human papillomavirus and breast cancer : a UK based study. Scientific Reports, 7, p. 43591. ISSN (online) 2045-2322

Amjadi, Omolbanin, Rafiei, Alireza, Haghshenas, Mohammadreza, Navaei, Reza Alizadeh, Valadan, Reza, Hosseini-Khah, Zahra, Omran, Akbar Hedayatizadeh, Arabi, Mohsen, Shakib, Reza Jafari, Mousavi, Tahoora and Ashrafi, G. Hossein (2017) A systematic review and meta-analysis of Seroprevalence of Varicella Zoster virus : a nationwide population-based study. Journal of Clinical Virology, 87, pp. 49-59. ISSN (print) 1386-6532

Motamed, Nima, Perumal, Dhaya, Zamani, Farhad, Ashrafi, Hossein, Haghjoo, Majid, Saeedian, F S, Maadi, Mansooreh, Akhavan-Niaki, Haleh, Rabiee, Behnam and Asouri, Mohsen (2015) Conicity index and waist-to-hip ratio are superior obesity indices in predicting 10-Year cardiovascular risk among men and women. Clinical Cardiology, 38(9), pp. 527-534. ISSN (print) 0160-9289

Ashrafi, Gholam Hossein and Perumal, Dhaya (2015) Human papillomavirus and cancer : immunological consequences of MHC Class I down-regulation. International Biological and Biomedical Journal, 1(1), pp. 1-7. ISSN (online) 2423-4478

Keyvani, Hossein, Sohrabi, Masoudreza, Zamani, Farhad, Poustchi, Hossein, Ashrafi, Hossein, Saeedian, Fatemeh, Mooadi, Mansooreh, Motamed, Nima, Ajdarkosh, Hossein, Khonsari, Mahmoodreza, Hemmasi, Gholamreza, Ameli, Mitra, Kabir, Ali and Khodadost, Mahmoud (2014) A population based study on hepatitis B virus in Northern Iran, Amol. Hepatitis Monthly, 14(8), e20540. ISSN (print) 1735-143X

Haghshenas, Mohammadreza, Golini-Moghaddam, Tahereh, Rafiei, Alireza, Emadeian, Omid, Shykhpour, Ahmad and Ashrafi, G Hossein (2013) Prevalence and type distribution of high-risk human papillomavirus in patients with cervical cancer: a population-based study. Infectious Agents and Cancer, 8(20), ISSN (online) 1750-9378

Cortese, Marc S., Ashrafi, G. Hossein and Campo, M. Saveria (2010) All 4 di-leucine motifs in the first hydrophobic domain of the E5 oncoprotein of human papillomavirus type 16 are essential for surface MHC class I downregulation activity and E5 endomembrane localization. International Journal of Cancer, 126(7), pp. 1675-1682. ISSN (print) 0020-7136

Ashrafi, G. H., Grinfeld, Esther, Montague, Paul [Auctioneer], Forster, Thorsten, Ross, Alan, Ghazal, Peter, Scott, Fiona, Breuer, Judith, Goodwin, Roslyn and Kennedy, Peter G. E. (2010) Assessment of transcriptomal analysis of varicella-zoster-virus gene expression in patients with and without post-herpetic neuralgia. Virus Genes, 41(2), pp. 192-201. ISSN (print) 0920-8569

Barbaresi, S., Cortese, M. S., Quinn, J., Ashrafi, G. H., Graham, S. V. and Campo, M. S. (2010) Effects of human papillomavirus type 16 E5 deletion mutants on epithelial morphology: functional characterization of each transmembrane domain. Journal of General Virology, 91(2), pp. 521-530. ISSN (print) 0022-1317

Campo, M.S., Graham, S.V., Cortese, M.S., Ashrafi, G.H., Araibi, E.H., Dornan, E.S., Miners, K., Nunes, C. and Man, S. (2010) HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells. Virology, 407(1), pp. 137-142. ISSN (print) 0042-6822

Ashrafi, G. H., Piuko, K., Burden, F., Yuan, Z., Gault, E. A., Muller, M., Trawford, A., Reid, S. W. J., Nasir, L. and Campo, M. S. (2008) Vaccination of sarcoid-bearing donkeys with chimeric virus-like particles of bovine papillomavirus type 1. Journal of General Virology, 89(1), p. 148. ISSN (print) 0022-1317

Ashrafi, G, Brown, D R, Fife, K and Campo, M (2006) Down-regulation of MHC class I is a property common to papillomavirus E5 proteins. Virus Research, 120(1-2), pp. 208-211. ISSN (print) 0168-1702

Araibi, E, Marchetti, B, Dornan, E. S., Ashrafi, G. H., Dobromylskyj, M, Ellis, S. A. and Campo, M. S. (2006) The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I. Virology, 353(1), pp. 174-183. ISSN (print) 0042-6822

Ashrafi, G. Hossein, Haghshenas, Mohammad, Marchetti, Barbara and Campo, M. Saveria (2006) E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chainvia its first hydrophobic domain. International Journal of Cancer, 119(9), pp. 2105-2122. ISSN (print) 0020-7136

Tsirimonaki, E, Ullah, R, Marchetti, B, Ashrafi, G, McGarry, L, Ozanne, B and Campo, M (2006) Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells. Virus Research, 115(2), pp. 158-168. ISSN (print) 0168-1702

Babamahmoodi, F, Aghabarari, F, Arjmand, A and Ashrafi, G (2006) Three rare cases of anthrax arising from the same source. Journal of Infection, 53(4), e175-e179. ISSN (print) 0163-4453

Marchetti, B, Ashrafi, G. H., Dornan, E. S., Araibi, E. H., Ellis, S. A. and Campo, M. S. (2005) The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus. Oncogene, 25(15), pp. 2254-2263. ISSN (print) 0950-9232

Ashrafi, G. Hossein, Haghshenas, Mohammad R., Marchetti, Barbara, O'Brien, Philippa M. and Campo, M. Saveria (2005) E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I. International Journal of Cancer, 113(2), pp. 276-283. ISSN (print) 0020-7136

Araibi, E. H., Marchetti, B, Ashrafi, G.H. and Campo, M.S. (2004) Downregulation of major histocompatibility complex class I in bovine papillomas. Journal of General Virology, 85(10), pp. 2809-2814. ISSN (print) 0022-1317

Ashrafi, G Hossein, Tsirimonaki, Emmanouella, Marchetti, Barbara, O'Brien, Philippa M, Sibbet, Gary J, Andrew, Linda and Campo, M Saveria (2002) Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins. Oncogene, 21(2), pp. 248-259. ISSN (print) 0950-9232

Marchetti, Barbara, Ashrafi, G Hossein, Tsirimonaki, Emmanouella, O'Brien, Philippa M and Campo, M Saveria (2002) The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surface. Oncogene, 21(51), pp. 7808-7816. ISSN (print) 0950-9232

Ashrafi, G. Hossein, Pitts, John D, Faccini, AnnaMaria, McLean, Pauline, O’Brien, Vincent, Finbow, Malcolm E and Campo, Saveria (2000) Binding of bovine papillomavirus type 4 E8 to ductin (16K proteolipid), down-regulation of gap junction intercellular communication and full cell transformation are independent events. Journal of General Virology, 81(3), pp. 694-689. ISSN (print) 0022-1317

O'Brien, V, Ashrafi, G. H, Grindlay, G. Joan, Anderson, Ruth and Campo, M. Saveria (1999) A Mutational Analysis of the Transforming Functions of the E8 Protein of Bovine Papillomavirus Type 4. Virology, 255(2), pp. 385-394. ISSN (print) 0042-6822

Book Section

Ashrafi, G. Hossein and Salman, Nadia Aziz (2016) Pathogenesis of human papillomavirus : immunological responses to HPV infection. In: Rajkumar, Rajamanickam, (ed.) Human papillomavirus : research in a global perspective. Rijeka, Croatia : Intech. pp. 243-253. ISBN 9789535124399

This list was generated on Fri Sep 22 04:47:56 2017 BST.
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