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Dr Jess Buxton

Senior Lecturer

About

I graduated from the University of Leeds with a degree in Genetics, and obtained my PhD in Human Genetics from Imperial College London, for which I carried out research into the molecular basis of myotonic dystrophy. After a postdoctoral position at the UCL Institute of Child Health London, working on another genetic condition, Angelman syndrome, I took a career break for family reasons. I returned to full-time research at Imperial College in 2009, supported by a Wellcome Trust Career Re-entry Fellowship. This funded my work on the identification of novel genetic, epigenetic and environmental factors associated with telomere length, a proposed biomarker of biological ageing. I carried out further postdoctoral work at University College London from 2014, before joining Kingston University as a Senior Lecturer in 2017.

Qualifications

  • Fellow of the Higher Education Academy (2015)
  • Diploma in Science Communication, Birkbeck College, University of London (1996)
  • PhD in Human Genetics, St Mary's and Charing Cross Medical Schools, Imperial College London (1992)
  • BSc (Hons) in Genetics, Leeds University (1988)

Research

My scientific interests lie in understanding the contribution of genetic variation and genomic integrity to human disease. During my early career, I investigated the molecular pathology underlying the monogenic conditions myotonic dystrophy and Angelman syndrome. More recently, I have worked on the identification of genetic and epigenetic factors associated with complex traits, particularly obesity and telomere length - an indicator of cellular ageing and an independent risk factor for age-related metabolic dysfunction.

Publications

Jump to: Article
Number of items: 11.

Article

Williams, Dylan M., Buxton, Jessica L., Kantomaa, Marko T., Tammelin, Tuija H., Blakemore, Alexandra I. F. and Jarvelin, Marjo-Riitta (2017) Associations of leukocyte telomere length with aerobic and muscular fitness in young adults. American Journal of Epidemiology, 185(7), pp. 529-537. ISSN (print) 0002-9262

Ruffmann, C., Calboli, F. C. F., Bravi, I., Gveric, D., Curry, L. K., de Smith, A., Pavlou, S., Buxton, J. L., Blakemore, A. I. F., Takousis, P., Molloy, S., Piccini, P., Dexter, D. T., Roncaroli, F., Gentleman, S. M. and Middleton, L. T. (2015) Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases. Neuropathology and Applied Neurobiology, 42(5), pp. 436-450. ISSN (print) 0305-1846

Hamad, Ibrahim A.Y., Beaney, Katherine E., Buxton, Jessica L. and Walker, Ann P. (2015) Double trouble : T2DM genetic risk factors play a causal role in CAD. Atherosclerosis, 241(2), pp. 766-768. ISSN (print) 0021-9150

Stathopoulou, Maria G., Petrelis, Alexandros M., Buxton, Jessica L., Froguel, Philippe, Blakemore, Alexandra I. F. and Visvikis-Siest, Sophie (2015) Genetic determinants of leucocyte telomere length in children : a neglected and challenging field. Paediatric and Perinatal Epidemiology, 29(2), pp. 146-150. ISSN (print) 0269-5022

Suderman, Matthew, Pappas, Jane J, Borghol, Nada, Buxton, Jessica L, McArdle, Wendy L, Ring, Susan M, Hertzman, Clyde, Power, Chris, Szyf, Moshe and Pembrey, Marcus (2015) Lymphoblastoid cell lines reveal associations of adult DNA methylation with childhood and current adversity that are distinct from whole blood associations. International Journal of Epidemiology, 44(4), pp. 1331-1340. ISSN (print) 0300-5771

Goldstone, Anthony P., Alsters, Suzanne I. M., Buxton, Jessica L., Zekavati, Anna, Sosinsky, Alona, Yiorkas, Andrianos M., Holder, Susan, Klaber, Robert E., Bridges, Nicola, van Haelst, Mieke M., le Roux, Carel W., Walley, Andrew J., Walters, Robin G., Mueller, Michael, Blakemore, Alexandra I. F., , and , (2015) Truncating homozygous mutation of Carboxypeptidase E (CPE) in a morbidly obese female with type 2 diabetes mellitus, intellectual disability and hypogonadotrophic hypogonadism. PLoS ONE, 10(6), e0131417. ISSN (online) 1932-6203

van der Valk, Ralf J.P., Kreiner-Moller, Eskil, Kooijman, Marjolein N., Guxens, Monica, Stergiakouli, Evangelia, Saaf, Annika, Bradfield, Jonathan P., Geller, Frank, Hayes, M. Geoffrey, Cousminer, Diana L., Korner, Antje, Thiering, Elisabeth, Curtin, John A., Myhre, Ronny, Huikari, Ville, Joro, Raimo, Kerkhof, Marjan, Warrington, Nicole M., Pitkanen, Niina, Ntalla, Ioanna, Horikoshi, Momoko, Veijola, Riitta, Freathy, Rachel M., Teo, Yik-Ying, Barton, Sheila J., Evans, David M., Kemp, John P., St Pourcain, Beate, Ring, Susan M., Davey Smith, George, Bergstrom, Anna, Kull, Inger, Hakonarson, Hakon, Mentch, Frank D., Bisgaard, Hans, Chawes, Bo, Stokholm, Jakob, Waage, Johannes, Eriksen, Patrick, Sevelsted, Astrid, Melbye, Mads, van Duijn, Cornelia M., Medina-Gomez, Carolina, Hofman, Albert, de Jongste, Johan C., Taal, H. Rob, Uitterlinden, André G., Armstrong, Loren L., Eriksson, Johan, Palotie, Aarno, Bustamante, Mariona, Estivill, Xavier, Gonzalez, Juan R., Llop, Sabrina, Kiess, Wieland, Mahajan, Anubha, Flexeder, Claudia, Tiesler, Carla M.T., Murray, Clare S., Simpson, Angela, Magnus, Per, Sengpiel, Verena, Hartikainen, Anna-Liisa, Keinanen-Kiukaanniemi, Sirkka, Lewin, Alexandra, Da Silva Couto Alves, Alexessander, Blakemore, Alexandra I., Buxton, Jessica L., Kaakinen, Marika, Rodriguez, Alina, Sebert, Sylvain, Vaarasmaki, Marja, Lakka, Timo, Lindi, Virpi, Gehring, Ulrike, Postma, Dirkje S., Ang, Wei, Newnham, John P., Lyytikainen, Leo-Pekka, Pahkala, Katja, Raitakari, Olli T., Panoutsopoulou, Kalliope, Zeggini, Eleftheria, Boomsma, Dorret I., Groen-Blokhuis, Maria, Ilonen, Jorma, Franke, Lude, Hirschhorn, Joel N., Pers, Tune H., Liang, Liming, Huang, Jinyan, Hocher, Berthold, Knip, Mikael, Saw, Seang-Mei, Holloway, John W., Melen, Erik, Grant, Struan F.A., Feenstra, Bjarke, Lowe, William L., Widen, Elisabeth, Sergeyev, Elena, Grallert, Harald, Custovic, Adnan, Jacobsson, Bo, Jarvelin, Marjo-Riitta, Atalay, Mustafa, Koppelman, Gerard H., Pennell, Craig E., Niinikoski, Harri, Dedoussis, George V., Mccarthy, Mark I., Frayling, Timothy M., Sunyer, Jordi, Timpson, Nicholas J., Rivadeneira, Fernando, Bonnelykke, Klaus and Jaddoe, Vincent W.V. (2015) A novel common variant in DCST2 is associated with length in early life and height in adulthood. Human Molecular Genetics, 24(4), pp. 1155-1168. ISSN (print) 0964-6906

Buxton, Jessica L., Suderman, Matthew, Pappas, Jane J., Borghol, Nada, McArdle, Wendy, Blakemore, Alexandra I. F., Hertzman, Clyde, Power, Christine, Szyf, Moshe and Pembrey, Marcus (2014) Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci. Scientific Reports, 4(4954), ISSN (online) 2045-2322

Buxton, Jessica L., Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Couto Alves, Alexessander, Sebert, Sylvain, Millwood, Iona Y., Laitinen, Jaana, O'Reilly, Paul F., Jarvelin, Marjo-Riitta and Blakemore, Alexandra I. F. (2014) Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966. PLoS ONE, 9(6), e99133. ISSN (online) 1932-6203

Blakemore, Alexandra I F and Buxton, Jessica L (2014) Obesity, genetic risk, and environment. BMJ, 348, g1900. ISSN (print) 0959-535X

Albrecht, Eva, Sillanpaa, Elina, Karrasch, Stefan, Alves, Alexessander, Codd, Veryan, Hovatta, Iiris, Buxton, Jessica L., Nelson, Christopher P., Broer, Linda, Hagg, Sara, Mangino, Massimo, Willemsen, Gonneke, Surakka, Ida, Ferreira, Manuel A.R., Amin, Najaf, Oostra, Ben A., Backmand, H. M., Peltonen, M., Sarna, S., Rantanen, T., Sipila, S., Korhonen, T., Madden, P. A. F., Gieger, C., Jorres, R. A., Heinrich, J., Behr, J., Huber, R. M., Peters, A., Strauch, K., Wichmann, H. E., Waldenberger, M., Blakemore, A. I. F., de Geus, E. J. C., Nyholt, D. R., Henders, A. K., Piirila, P. L., Rissanen, A., Magnusson, P. K. E., Vinuela, A., Pietilainen, K. H., Martin, N. G., Pedersen, N. L., Boomsma, D. I., Spector, T. D., van Duijn, C. M., Kaprio, J., Samani, N. J., Jarvelin, M.-R. and Schulz, H. (2014) Telomere length in circulating leukocytes is associated with lung function and disease. European Respiratory Journal, 43(4), pp. 983-992. ISSN (print) 0903-1936

This list was generated on Thu Feb 22 04:29:22 2018 GMT.
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