Professor Helmout Modjtahedi

Article

Al-Janaby, Tina, Nahi, Narmin, Seddon, Alan, Bagwan, Izhar, Khelwatty, Said and Modjtahedi, Helmout (2024) The combination of afatinib with dasatinib or miransertib results in synergistic growth inhibition of stomach cancer cells. World Journal of Oncology, 15(2), pp. 192-208. ISSN (print) 1920-4531

Khan, Tanzeel, Seddon, Alan, Khelwatty, Said, Dalgleish, Angus, Bagwan, Izhar, Mudan, Satvinder and Modjtahedi, Helmout (2023) The co-expression of HER family members and CD109 is common in pancreatic cancer. Medical Research Archives, 11(11), ISSN (online) 2375-1924

Ismail, Mohamed A., Nasrallah, Gheyath K., Monne, Maria, AlSayab, Ali, Yassin, Mohamed A., Varadharaj, Govindarajulu, Younes, Salma, Sorio, Claudio, Cook, Richard, Modjtahedi, Helmout and Al-Dewik, Nader (2022) Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors. Gene, 813, p. 146101. ISSN (print) 0378-1119

Bazzi, Samer, El-Darzi, Emale, McDowell, Tina, Modjtahedi, Helmout, Mudan, Satvinder, Achkar, Marcel, Akle, Charles, Kadara, Humam and Bahr, Georges M. (2021) Cytokine/chemokine release patterns and transcriptomic profiles of LPS/IFNγ-activated human macrophages differentiated with heat-killed 'Mycobacterium obuense', M-CSF, or GM-CSF. International Journal of Molecular Sciences, 22(13), p. 7214. ISSN (print) 1661-6596

Ismail, Mohamed A., Vezzalini, Marzia, Morsi, Hisham, Abujaber, Ahmad, Al Sayab, Ali, Siveen, Kodappully, Yassin, Mohamed A., Monne, Maria, Samara, Muthanna, Cook, Richard, Sorio, Claudio, Modjtahedi, Helmout and Al-Dewik, Nader I. (2021) Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients. Scientific Reports, 11, p. 8833. ISSN (online) 2045-2322

A. Arias-Pinilla, Gustavo and Modjtahedi, Helmout (2021) Therapeutic application of monoclonal antibodies in pancreatic cancer : advances, challenges and future opportunities. Cancers, 13(8), e1781. ISSN (print) 2072-6694

Khelwatty, Said A., Puvanenthiran, Soozana, Essapen, Sharadah, Bagwan, Izhar, Seddon, Alan M. and Modjtahedi, Helmout (2021) HER2 expression is predictive of survival in cetuximab treated patients with RAS wild type metastatic colorectal cancer. Cancers, 13(4), e638. ISSN (print) 2072-6694

Khan, Tanzeel, Seddon, Alan M., Dalgleish, Angus G., Khelwatty, Said, Ioannou, Nikolaos, Mudan, Satvinder and Modjtahedi, Helmout (2020) Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations : implications for future clinical trials in pancreatic cancer. Oncology Reports, 44(6), pp. 2581-2594. ISSN (print) 1021-335X

Ismail, Mohamed A., Samara, Muthanna, Al Sayab, Ali, Alshashani, Mohamed, Yassin, Mohamed A., Varadharaj, Govindaraiulu, Vezzalini, Mariza, Tomasello, Luisa, Monne, Maria, Morsi, Hisham, Qoronfleh, M. Walid, Zayed, Hatem, Cook, Richard, Sorio, Claudio, Modjtahedi, Helmout and Al-Dewik, Nader I. (2020) Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the state of Qatar. Molecular Genetics and Genomic Medicine, 8(10), e1319. ISSN (online) 2324-9269

Arias-Pinilla, Gustavo A., Dalgleish, Angus G., Mudan, Satvinder, Bagwan, Izhar, Walker, Anthony J. and Modjtahedi, Helmout (2020) Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer. Scientific Reports, 10, p. 537. ISSN (online) 2045-2322

Khelwatty, Said Abdullah, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan M. and Modjtahedi, Helmout (2019) Co-expression and prognostic significance of putative CSC markers CD44, CD133, wild-type EGFR and EGFRvIII in metastatic colorectal cancer. Oncotarget, 10(18), pp. 1704-1715. ISSN (online) 1949-2553

Puvanenthiran, S., Essapen, S., Haagsma, B., Bagwan, I., Green, M., Khelwatty, S. A., Seddon, A. M. and Modjtahedi, H. (2018) Co-expression and prognostic significance of the HER family members, EGFRvIII, c-MET, CD44 in patients with ovarian cancer. Oncotarget, 9, pp. 19662-19674. ISSN (online) 1949-2553

Arias-Pinilla, Gustavo A., Dalgleish, Angus G., Mudan, Satvinder, Bagwan, Izhar, Walker, Anthony J. and Modjtahedi, Helmout (2018) Development of novel monoclonal antibodies against CD109 overexpressed in human pancreatic cancer. Oncotarget, 9, pp. 19994-20007. ISSN (online) 1949-2553

Abdolahpour, Saeideh, Toliyat, Tayebeh, Omidfar, Kobra, Modjtahedi, Helmout, Wong, Albert J., Rasaee, Mohammad Javad, Kashanian, Susan and Paknejad, Maliheh (2018) Targeted delivery of doxorubicin into tumor cells by nanostructured lipid carriers conjugated to anti-EGFRvIII monoclonal antibody. Artificial Cells, Nanomedicine, and Biotechnology, 46(1), pp. 89-94. ISSN (print) 2169-1401

Asadi-Ghalehni, Majid, Rasaee, Mohamad Javad, RajabiBazl, Masoumeh, Khosravani, Masood, Motaghinejad, Majid, Javanmardi, Masoud, Khalili, Saeed, Modjtahedi, Helmout and Sadroddiny, Esmaeil (2017) A novel recombinant anti-epidermal growth factor receptor peptide vaccine capable of active immunization and reduction of tumor volume in a mouse model. Microbiology and Immunology, 61(12), pp. 531-538. ISSN (print) 0385-5600

Bazzi, Samer, Modjtahedi, Helmout, Mudan, Satvinder, Achkar, Marcel, Akle, Charles and Bahr, Georges (2017) Immunomodulatory effects of heat killed 'Mycobacterium obuense' on human blood dendritic cells. Innate Immunity, 23(7), pp. 592-605. ISSN (print) 1753-4259

Bazzi, Samer, El-Darzi, Emale, McDowell, Tina, Modjtahedi, Helmout, Mudan, Satvinder, Achkar, Marcel, Akle, Charles, Kadara, Humam and Bahr, Georges M (2017) Defining genome-wide expression and phenotypic contextual cues in macrophages generated by GM-CSF, M-CSF and heat-killed mycobacteria. Frontiers in Immunology, 8, p. 1253. ISSN (online) 1664-3224

Jaksevicius, Andrius, Carew, Mark, Mistry, Calli, Modjtahedi, Helmout and Opara, Elizabeth I (2017) Inhibitory effects of culinary herbs and spices on the growth of HCA-7 colorectal cancer cells and their COX-2 expression. Nutrients, 9(10), ISSN (online) 2072-6643

Stanley, Aryan, Ashrafi, G. Hossein, Seddon, Alan M. and Modjtahedi, Helmout (2017) Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines. Scientific Reports, 7(3964), ISSN (online) 2045-2322

Khelwatty, Said, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan and Modjtahedi, Helmout (2016) The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer. Oncotarget, 8(5), pp. 7666-7677. ISSN (online) 1949-2553

Puvanenthiran, Soozana, Essapen, Sharadah, Seddon, Alan and Modjtahedi, Helmout (2016) Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of the HER inhibitors and cytotoxic drugs. International Journal Of Oncology, 49(5), pp. 1825-1838. ISSN (print) 1019-6439

Ioannou, Nikolaos, Seddon, Alan, Dalgleish, Angus, Mackintosh, David, Solca, Flavio and Modjtahedi, Helmout (2016) Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition. International Journal Of Oncology, 48(3), pp. 908-918. ISSN (print) 1019-6439

Bazzi, Samer, Modjtahedi, Helmout, Mudan, Satvinder, Akle, Charles and Bahr, Georges M (2015) Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model. Immunobiology, 220(12), pp. 1293-1304. ISSN (print) 0171-2985

Khelwatty, Said A., Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout (2015) Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers. British Journal of Cancer, 113(7), pp. 1010-1019. ISSN (print) 0007-0920

Navari, Mohsen, Zare, Mehrak, Javanmardi, Masoud, Asadi-Ghalehni, Majid, Modjtahedi, Helmout and Rasaee, Mohammad Javed (2014) Epitope mapping of epidermal growth factor receptor (EGFR) monoclonal antibody and induction of growth-inhibitory polyclonal antibodies by vaccination with EGFR mimotope. Immunopharmacology and Immunotoxicology, 36(5), pp. 309-315. ISSN (print) 0892-3973

Khelwatty, Said Abdullah, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan and Modjtahedi, Helmout (2014) Co-expression of HER family members in patients with Dukes' C and D colon cancer and their impacts on patient prognosis and survival. PloS one, 9(3), e91139. ISSN (print) 1932-6203

Modjtahedi, Helmout, Cho, Byoung Chul, Michel, Martin C and Solca, Flavio (2014) A comprehensive review of the preclinical efficacy profile of the ErbB family blocker afatinib in cancer. Naunyn-Schmiedeberg's archives of pharmacology, ISSN (print) 0028-1298

Modjtahedi, Helmout and Eccles, Suzanne (2014) GA201: a novel humanized and glycoengineered anti-EGFR antibody. Clinical Cancer Research, 20(4), pp. 1053-1054. ISSN (print) 1078-0432

Polycarpou, Elena, Meira, Lisiane B, Carrington, Simon, Tyrrell, Elizabeth, Modjtahedi, Helmout and Carew, Mark A (2013) Resveratrol 3-O-d-glucuronide and resveratrol 4'-O-d-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. Molecular Nutrition and Food Research, 57(10), pp. 1708-1717. ISSN (print) 1613-4125

Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, Mackintosh, David and Modjtahedi, Helmout (2013) Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells. BMC Cancer, 13(41), ISSN (print) 1471-2407

Modjtahedi, Helmout, Ioannou, Nikolaos, Dalgleish, Angus, Mackintosh, David and Seddon, Alan M. (2013) Co-targeting of HER family members and IGF-IR in pancreatic cancer. International Journal Of Molecular Medicine, 32, S40-S40. ISSN (print) 1107-3756

Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan Michael and Modjtahedi, Helmout (2013) Prognostic significance and targeting of HER family in colorectal cancer. Frontiers in Bioscience, 18(2), pp. 394-421. ISSN (print) 1093-9946

Modjtahedi, Helmout, Ali, Sumaira and Essapen, Sharadah (2012) Therapeutic application of monoclonal antibodies in cancer: advances and challenges. British Medical Bulletin, 104(1), pp. 41-59. ISSN (print) 0007-1420

Modjtahedi, H., Khelwatty, S.A., Kirk, R.S., Seddon, A.M., Essapen, S., Del Vecchio, C.A., Wong, A.J. and Eccles, S. (2012) Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10. British Journal of Cancer, 106, pp. 883-888. ISSN (print) 0007-0920

Ioannou, N., Seddon, A.M., Dalgleish, A., Mackintosh, D. and Modjtahedi, H. (2012) Expression pattern and targeting of HER family members and IGF-IR in pancreatic cancer. Frontiers in Bioscience, 17(1), pp. 2698-2724. ISSN (print) 1093-9946

Ioannou, N, Dalgleish, A G, Seddon, A M, Mackintosh, D, Guertler, U, Solca, F and Modjtahedi, H (2011) Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells. British Journal of Cancer, 105(10), pp. 1554-1562. ISSN (print) 0007-0920

Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan M. and Modjtahedi, Helmout (2011) Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members. International Journal of Oncology, 39(2), pp. 483-491. ISSN (print) 1019-6439

Shafi, Shahida, Lamb, David, Modjtahedi, Helmout and Ferns, Gordon (2010) Periadventitial delivery of anti-EGF receptor antibody inhibits neointimal macrophage accumulation after angioplasty in a hypercholesterolaemic rabbit. International Journal Of Experimental Pathology, 91(3), pp. 224-234. ISSN (print) 0959-9673

Modjtahedi, Helmout and Essapen, Sharadah (2009) Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities. Anti-Cancer Drugs, 20(10), pp. 851-855. ISSN (print) 0959-4973

Cunningham, Matthew P., Thomas, Hilary, Marks, Christopher, Green, Margaret, Fan, Zhen and Modjtahedi, Helmout (2008) Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells. International Journal of Oncology, 33(5), pp. 1107-1113. ISSN (print) 1019-6439

Cunningham, Matthew P., Thomas, Hilary, Fan, Zhen and Modjtahedi, Helmout (2006) Responses of human colorectal tumor cells to treatment with the anti–epidermal growth factor receptor monoclonal antibody ICR62 used alone and in combination with the EGFR tyrosine kinase inhibitor gefitinib. Cancer Research, 66(15), pp. 7708-7715. ISSN (print) 0008-5472

Cunningham, Matthew P., Essapen, Sharadah, Thomas, Hilary, Green, Margaret, Lovell, David P., Topham, Clare, Marks, Christopher and Modjtahedi, Helmout (2005) Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer. International Journal of Oncology, 27(2), pp. 317-325. ISSN (print) 1019-6439

Essapen, Sharadah, Thomas, Hilary, Green, Margaret, De Vries, Corrine, Cook, Martin G., Marks, Christopher, Topham, Clare and Modjtahedi, Helmout (2004) The expression and prognostic significance of HER-2 in colorectal cancer and its relationship with clinicopathalogical parameters. International Journal of Oncology, 24(2), pp. 241-248. ISSN (print) 1019-6439

Modjtahedi, Helmout, Moscatello, David K., Box, Gary, Green, Margaret, Shotton, Christine, Lamb, David J., Reynolds, Lesley J., Wong, Albert J., Dean, Christopher, Thomas, Hilary and Eccles, Suzanne (2003) Targeting of cells expressing wild-type EGFR and type-III mutant EGFR (EGFRvIII) by anti EGFR MAb ICR62: A two-pronged attack for tumour therapy. International Journal of Cancer, 105(2), pp. 273-280. ISSN (print) 0020-7136

Conference or Workshop Item

Arias Pinilla, GA, Dalgleish, AG, Mudan, S, Bagwan, I, Walker, AJ and Modjtahedi, H (2018) Development of two novel monoclonal antibodies against overexpressed antigens on pancreatic cancer cells for use in diagnosis and therapy. In: 25th Biennial Congress of the European Association for Cancer Research (EACR25) : From Fundamental Insight to Rational Cancer Treatment; 30 Jun - 03 Jul 2018, Amsterdam, The Netherlands.

Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout (2013) Acquired resistance to anti-EGFR mAb ICR62 or afatinib is accompanied by upregulation of the EGFR in colorectal cancer. In: 104th Annual Meeting of the American Association for Cancer Research; 6-10 Apr 2013, Washington, U.S.A..