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Professor Mike Sutcliffe

Dean of SEC/PVC

About

I am currently Pro Vice-Chancellor and Dean of the Faculty of Science, Engineering and Computing at Kingston University – responsible for the strategic direction and operational management of the Faculty.  Prior to this, I was (2008-15) Head of the School of Chemical Engineering and Analytical Science at the University of Manchester – leading it into the top 25 chemical engineering departments globally, into the top three in research in the UK in REF 2014 and to an Athena Swan Silver Award. I also led the design and delivery of a new £16M ‘BREEAM Excellent' state-of-the-art building.  I have received awards for my teaching and research, and have established partnerships with leading multinational companies.

Qualifications

  • 1985-8 PhD Birkbeck College, London: developing the first automated protein modelling software
  • 1982-5 BSc Chemical Physics, University of Bristol

Professional membership

CChem FRSC

CEng FIChemE

Engineering Professors' Council Board Member

Publications

Number of items: 166.

Article

Jones, Steven, Sutcliffe, Michael J., Bragg, Joanna and Harris, Diane (2016) To what extent is capital expenditure in UK higher education meeting the pedagogical needs of staff and students? Journal of Higher Education Policy and Management, 38(4), pp. 477-489. ISSN (print) 1360-080X

Pang, Jiayun, Scrutton, Nigel and Sutcliffe, Michael, J. (2014) Quantum mechanics/molecular mechanics studies on the mechanism of action of cofactor pyridoxal 5′-phosphate in ornithine 4,5-aminomutase. Chemistry - A European Journal, 20(36), pp. 11390-11401. ISSN (online) 1521-3765

Pang, Jiayun, Li, Xin, Morokuma, Keiji, Scrutton, Nigel, S. and Sutcliffe, Michael, J. (2012) Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B 12-dependent enzyme ornithine 4,5-aminomutase: A computational study. Journal of the American Chemical Society, 134(4), pp. 2367-2377. ISSN (print) 0002-7863

Hay, Sam, Johannissen, Linus, O., Hothi, Parvinder, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2012) Pressure effects on enzyme-catalyzed quantum tunneling events arise from protein-specific structural and dynamic changes. Journal of the American Chemical Society, 134(23), pp. 9749-9754. ISSN (print) 0002-7863

Ivanova, Ekaterina, Pang, Jiayun, Jowitt, Thomas, A., Yan, Guanha, Warwicker, Jim, Sutcliffe, Michael, J. and Lu, Hui (2012) Temperature-dependent study reveals that dynamics of hydrophobic residues plays an important functional role in the mitochondrial Tim9-Tim10 complex. Proteins: Structure, Function and Bioinformatics, 80(2), pp. 602-615. ISSN (online) 1097-0134

Stevenson, Bradley, J., Bibby, Jaclyn, Pignatelli, Patricia, Muangnoicharoen, Sant, O’Neill, Paul, M., Lian, Lu-Yun, Müller, Pie, Nikou, Dimitra, Steven, Andrew, Hemingway, Janet, Sutcliffe, Michael, J. and Paine, Mark, J.I. (2011) Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. Insect Biochemistry and Molecular Biology, 41(7), pp. 492-502. ISSN (print) 0965-1748

Niazi, Umar, H.K., Bibby, Jaclyn and Sutcliffe, Michael, J. (2011) In-silico characterization of the effects of phosphorylated tyrosines 86 and 106 on structure and binding of MAL: Insight into hyperinflammatory response to infection by the human malaria parasites. Journal of Receptors and Signal Transduction, 31(1), pp. 53-65. ISSN (print) 1079-9893

Pang, Jiayun, Scrutton, Nigel, S., de Visser, Sam, P. and Sutcliffe, Michael, J. (2010) Assignment of the vibrational spectra of enzyme-bound tryptophan tryptophyl quinones using a combined QM/MM approach. Journal of Physical Chemistry A, 114(2), pp. 1212-1217. ISSN (print) 1089-5639

Hay, Sam, Johannissen, Linus, O., Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2010) Barrier compression and its contribution to both classical and quantum mechanical aspects of enzyme catalysis. Biophysical Journal, 98(1), pp. 121-128. ISSN (print) 0006-3495

Pudney, Christopher, R., Johannissen, Linus, O., Sutcliffe, Michael, J., Hay, Sam and Scrutton, Nigel, S. (2010) Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions. Journal of the American Chemical Society, 132(32), pp. 11329-11335. ISSN (print) 0002-7863

Pang, Jiayun, Scrutton, Nigel, S., de Visser, Sam, P. and Sutcliffe, Michael, J. (2010) New insights into the multi-step reaction pathway of the reductive half-reaction catalysed by aromatic amine dehydrogenase: A QM/MM study. Chemical Communications, 46(18), pp. 3104-3106. ISSN (print) 1359-7345

Hay, Sam, Pudney, Christopher, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2010) Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction. Journal of Physical Organic Chemistry, 23(7), pp. 696-701. ISSN (print) 0894-3230

Williamson, Mike, P. and Sutcliffe, Michael, J. (2010) Protein-protein interactions. Biochemical Society Transactions, 38(4), pp. 875-878. ISSN (print) 0300-5127

Hay, Sam, Pudney, Christopher, McGrory, Tom, A., Pang, Jiayun, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2009) Barrier compression enhances an enzymatic hydrogen-transfer reaction. Angewandte Chemie - International Edition, 48(8), pp. 1452-1454. ISSN (print) 1433-7851

Pudney, Christopher, R., Hay, Sam, Levy, Colin, Pang, Jiayun, Sutcliffe, Michael, J., Leys, David and Scutton, Nigel, S. (2009) Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. Journal of the American Chemical Society, 131(47), pp. 17072-17073. ISSN (print) 0002-7863

Shields, Mario, Niazi, Umar, Badal, Simone, Yee, Trevor, Sutcliffe, Michael, J. and Delgoda, Rupika (2009) Inhibition of CYP1A1 by quassinoids found in Picrasma excelsa. Planta Medica, 75(2), pp. 137-141. ISSN (print) 0032-0943

Pudney, Christopher, R., McGrory, Tom, Lafite, Pierre, Pang, Jiayun, Hay, Sam, Leys, David, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2009) Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure. ChemBioChem, 10(8), pp. 1379-1384. ISSN (print) 1439-4227

Porro, Cristina, S., Sutcliffe, Michael, J. and de Visser, Sam, P. (2009) Quantum mechanics/molecular mechanics studies on the sulfoxidation of dimethyl sulfide by compound i and compound 0 of cytochrome p450: Which is the better oxidant. Journal of Physical Chemistry A, 113(43), pp. 11635-11642. ISSN (print) 1089-5639

Ashmole, I., Vavoulis, D.V., Stansfeld, P.J., Mehta, Puja, R., Feng, J.F., Sutcliffe, M.J. and Stanfield, P.R. (2009) The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage: Gating at the cytoplasmic mouth. Journal of Physiology, 587(20), pp. 4769-4783. ISSN (print) 0022-3751

Hay, Sam, Pudney, Christopher, R., Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2008) Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity? Angewandte Chemie - International Edition, 47(3), pp. 537-540. ISSN (print) 1433-7851

Hay, Sam, Pudney, Christopher, Hothi, Parvinder, Johannissen, Linus, O., Masgrau, Laura, Pang, Jiayun, Leys, David, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2008) Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation. Biochemical Society Transactions, 36(1), pp. 16-21. ISSN (print) 0300-5127

Sattelle, Benedict, M. and Sutcliffe, Michael, J. (2008) Calculating chemically accurate redox potentials for engineered flavoproteins from classical molecular dynamics free energy simulations. Journal of Physical Chemistry A, 112(50), pp. 13053-13057. ISSN (print) 1089-5639

Roberts, Jonathan, A., Digby, Helen, R., Kara, Madina, El Ajouz, Sam, Sutcliffe, Michael, J. and Evans, Richard, J. (2008) Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors. Journal of Biological Chemistry, 283(29), pp. 20126-20136. ISSN (print) 0021-9258

Pang, Jiayun, Hay, Sam, Scrutton, Nigel, S. and Sutcliffe, Michael, J. (2008) Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase. Journal of the American Chemical Society, 130(22), pp. 7092-7097. ISSN (print) 0002-7863

Hothi, Parvinder, Hay, Sam, Roujeinikova, Anna, Sutcliffe, Michael, J., Lee, Michael, Leys, David, Cullis, Paul, M. and Scrutton, Nigel, S. (2008) Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex. Chembiochem : a European journal of chemical biology, 9(17), pp. 2839-2845. ISSN (print) 1439-4227

Balding, Philip, R., Porro, Cristina, S., McLean, Kirsty, J., Sutcliffe, Michael, J., Maréchal, Jean-Didier, Munro, Andrew, W. and de Visser, Sam, P. (2008) How do azoles inhibit cytochrome P450 enzymes? A density functional study. Journal of Physical Chemistry A, 112(50), pp. 12911-12918. ISSN (print) 1089-5639

Stansfeld, Phillip, J., Grottesi, Alessandro, Sands, Zara, A., Sansom, Mark, S.P., Gedeck, Peter, Gosling, Martin, Stanfield, Peter, R., Mitcheson, John, S. and Sutcliffe, Michael, J. (2008) Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations. Biochemistry, 47(28), pp. 7414-7422. ISSN (print) 0006-2960

Kapelyukh, Yury, Paine, Mark, J.I., Maréchal, Jean-Didier, Sutcliffe, Michael, J., Wolf, C. Roland and Roberts, Gordon, C.K. (2008) Multiple substrate binding by cytochrome P450 3A4: Estimation of the number of bound substrate molecules. Drug Metabolism and Disposition, 36(10), pp. 2136-2144. ISSN (print) 0090-9556

Hay, Sam, Pang, Jiayun, Monaghan, Phillip, J., Wang, Xi, Evans, Rhiannon, M., Sutcliffe, Michael, J., Allemann, Rudolf, K. and Scrutton, Nigel, S. (2008) Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions. ChemPhysChem, 9(11), pp. 1536-1539. ISSN (print) 1439-4235

Hay, Sam, Pudney, Christopher, R., Sutcliffe, Michael, J. and Nigel, Nigel, S. (2008) Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase. ChemPhysChem, 9(13), pp. 1875-1881. ISSN (print) 1439-4235

Johannissen, Linus, O., Scrutton, Nigel, S. and Sutcliffe, Michael, J. (2008) The enzyme aromatic amine dehydrogenase induces a substrate conformation crucial for promoting vibration that significantly reduces the effective potential energy barrier to proton transfer. Journal of the Royal Society Interface, 5(SUPPL. 3), S225-S232. ISSN (print) 1742-5689

Ranaghan, Kara, E., Masgrau, Laura, Scrutton, Nigel, S., Sutcliffe, Michael, J. and Mulholland, Adrian, J. (2007) Analysis of classical and quantum paths for deprotonation of methylamine by methylamine dehydrogenase. ChemPhysChem, 8(12), pp. 1816-1835. ISSN (print) 1439-4235

Stansfeld, Phillip, J., Gedeck, Peter, Gosling, Martin, Cox, Brian, Mitcheson, John, S. and Sutcliffe, Michael, J. (2007) Drug block of the hERG potassium channel: Insight from modeling. Proteins: Structure, Function and Genetics, 68(2), pp. 568-580. ISSN (online) 1097-0134

Pudney, Christopher, R., Hay, Sam, Pang, Jiayun, Costello, Claire, Leys, David, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2007) Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. Journal of the American Chemical Society, 129(45), pp. 13949-13956. ISSN (print) 0002-7863

Roujeinikova, Anna, Hothi, Parvinder, Masgrau, Laura, Sutcliffe, Michael, J., Scrutton, Nigel, S. and Leys, David (2007) New insights into the reductive half-reaction mechanism of aromatic amine dehydrogenase revealed by reaction with carbinolamine substrates. Journal of Biological Chemistry, 282(33), pp. 23766-23777. ISSN (print) 0021-9258

Hay, Sam, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2007) Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects. Proceedings of the National Academy of Sciences of the United States of America, 104(2), pp. 507-512. ISSN (print) 0027-8424

Johannissen, Linus, O., Hay, Sam, Scrutton, Nigel, S. and Sutcliffe, Michael, J. (2007) Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: Consistency of simulation and theory with experiment. Journal of Physical Chemistry B, 111(10), pp. 2631-2638. ISSN (print) 1520-6106

Masgrau, Laura, Ranaghan, Kara, E., Scrutton, Nigel, S., Mulholland, Adrian, J. and Sutcliffe, Michael, J. (2007) Tunneling and classical paths for proton transfer in an enzyme reaction dominated by tunneling: Oxidation of tryptamine by aromatic amine dehydrogenase. Journal of Physical Chemistry B, 111(11), pp. 3032-3047. ISSN (print) 1520-6106

Yuill, K.H., Stansfeld, P.J., Ashmole, I., Sutcliffe, M. J. and Stanfield, P.R. (2007) The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: Contributions of the pore domains. Pflugers Archiv - European Journal of Physiology, 455(2), pp. 333-348. ISSN (print) 0031-6768

Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus, O., Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara, E., Mulholland, Adrian, J., Sutcliffe, Michael, J., Scrutton, Nigel, S. and Leys, David (2006) Atomic description of an enzyme reaction dominated by proton tunneling. Science, 312(5771), pp. 237-241. ISSN (print) 0036-8075

Mahale, Sachin, Aubry, Carine, Wilson, A. James, Jenkins, Paul, R., Maréchal, Jean-Didier, Sutcliffe, Michael, J. and Chaudhuri, Bhabatosh (2006) CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation. Bioorganic and Medicinal Chemistry Letters, 16(16), pp. 4272-4278. ISSN (print) 0960-894X

Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2006) Computational studies of enzyme mechanism: Linking theory with experiment in the analysis of enzymic H-tunnelling. Physical Chemistry Chemical Physics, 8(39), pp. 4510-4516. ISSN (print) 1463-9076

Perry, Matthew, Stansfeld, Phillip, J., Leaney, Joanne, Wood, Claire, de Groot, Marcel, J., Leishman, Derek, Sutcliffe, Michael, J. and Mitcheson, John, S. (2006) Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs. Molecular Pharmacology, 69(2), pp. 509-519. ISSN (print) 0026-895X

Sutcliffe, Michael, J., Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus, O., Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara, E., Mulholland, Adrian, J., Leys, David and Scrutton, Nigel, S. (2006) Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: Flavoprotein and quinoprotein systems. Philosophical Transactions of the Royal Society B. Biological Sciences, 361(1472), pp. 1375-1386. ISSN (print) 0962-8436

de Groot, Marcel, J., Kirton, Stewart, B. and Sutcliffe, Michael, J. (2006) In silico methods for predicting ligand binding determinants of crtochromes p450. Frontiers in Medicinal Chemistry, 3(1), pp. 615-652. ISSN (print) 1567-2042

Yu, Yinglei, Paine, Mark, J.I., Maréchal, Jean-Didier, Kemp, Carol, A., Ward, Clive, J., Brown, Simon, Sutcliffe, Michael, J., Roberts, Gordon, C.K., Rankin, Elaine, M. and Wolf, C. Roland (2006) In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide. Drug Metabolism and Disposition, 34(8), pp. 1386-1392. ISSN (print) 0090-9556

Mahale, Sachin, Aubry, Carine, Jenkins, Paul, R., Maréchal, Jean-Didier, Sutcliffe, Michael, J. and Chaudhuri, Bhabatosh (2006) Inhibition of cancer cell growth by cyclin dependent kinase 4 inhibitors synthesized based on the structure of fascaplysin. Bioorganic Chemistry, 34(5), pp. 287-297. ISSN (print) 0045-2068

Dutton, P. Leslie, Munro, Andrew, W., Scrutton, Nigel, S. and Sutcliffe, Michael, J. (2006) Introduction. Quantum catalysis in enzymes: Beyond the transition state theory paradigm. Philosophical Transactions of the Royal Society B: Biological Sciences, 361(1472), pp. 1293-1294. ISSN (print) 0962-8436

Stansfeld, Phillip, J., Sutcliffe, Michael, J. and Mitcheson, John, S. (2006) Molecular mechanisms for drug interactions with hERG that cause long QT syndrome. Expert Opinion on Drug Metabolism and Toxicology, 2(1), pp. 81-94. ISSN (print) 1742-5255

McLean, Kirsty, Clift, Daniel, Lewis, Geraint, Sabri, Muna, Balding, Philip, R., Sutcliffe, Michael, J., Leys, David and Munro, Andrew, W. (2006) The preponderance of P450s in the Mycobacterium tuberculosis genome. Trends in Microbiology, 14(5), pp. 220-228. ISSN (print) 0966-842X

Pudney, Christopher, R., Hay, Sam, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2006) α-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models. Journal of the American Chemical Society, 128(43), pp. 14053-14058. ISSN (print) 0002-7863

McLean, K.J., Sabri, M., Marshall, K.R., Lawson, R.J., Lewis, D.G., Clift, D., Balding, P.R., Dunford, A.J., Warman, A.J., McVey, J.P., Quinn, A.M., Sutcliffe, M.J., Scrutton, N.S. and Munro, A.W. (2005) Biodiversity of cytochrome P450 redox systems. Biochemical Society Transactions, 33(4), pp. 796-801. ISSN (print) 0300-5127

Digby, Helen, R., Roberts, Jonathan, A., Sutcliffe, Michael, J. and Evans, Richard, J. (2005) Contribution of conserved glycine residues to ATP action at human P2X 1 receptors: Mutagenesis indicates that the glycine at position 250 is important for channel function. Journal Of Neurochemistry, 95(6), pp. 1746-1754. ISSN (print) 0022-3042

Rigby, S.E., Basran, J., Combe, J.P., Mohsen, A.W., Toogood, H., van Thiel, A., Sutcliffe, M.J., Leys, D., Munro, A.W. and Scrutton, N.S. (2005) Flavoenzyme catalysed oxidation of amines: Roles for flavin and protein-based radicals. Biochemical Society Transactions, 33(4), pp. 754-757. ISSN (print) 0300-5127

Hothi, Parvinder, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2005) Kinetic isotope effects and ligand binding in PQQ-dependent methanol dehydrogenase. Biochemical Journal, 388(1), pp. 123-133. ISSN (print) 0264-6021

Kemp, Carol, A., Maréchal, Jean-Didier and Sutcliffe, Michael, J. (2005) Progress in cytochrome P450 active site modeling. Archives of Biochemistry and Biophysics, 433(2), pp. 361-368. ISSN (print) 0003-9861

Messiha, Hanan, L., Bruce, Neil, C., Sattelle, Benedict, M., Sutcliffe, Michael, J., Munro, Andrew, W. and Scrutton, Nigel, S. (2005) Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase. The Journal of Biological Chemistry, 280(29), pp. 27103-27110. ISSN (print) 0021-9258

MacFarlane, Marion, Kohlhaas, Susan, L., Sutcliffe, Michael, J., Dyer, Martin, J.S. and Cohen, Gerald, M. (2005) TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies. Cancer Research, 65(24), pp. 11265-11270. ISSN (print) 0008-5472

McLaughlin, Lesley, A., Paine, Mark, J.I., Kemp, Carol, A., Maréchal, Jean-Didier, Flanagan, Jack, U., Ward, Clive, J., Sutcliffe, Michael, J., Roberts, Gordon, C.K. and Wolf, C. Roland (2005) Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding. The Journal of Biological Chemistry, 280(46), pp. 38617-38624. ISSN (print) 0021-9258

Aubry, Carine, Patel, Asma, Mahale, Sachin, Chaudhuri, Bhabatosh, Maréchal, Jean-Didier, Sutcliffe, Michael, J. and Jenkins, Paul, R. (2005) The design and synthesis of novel 3-2-indol-1-yl-ethyl-1H-indole derivatives as selective inhibitors of CDK4. Tetrahedron Letters, 46(9), pp. 1423-1425. ISSN (print) 0040-4039

Toogood, Helen, S., van Thiel, Adam, Basran, Jaswir, Sutcliffe, Mike, J., Scrutton, Nigel, S. and Leys, David (2004) Extensive domain motion and electron transfer in the human electron transferring flavoprotein·medium chain acyl-CoA dehydrogenase complex. The Journal of Biological Chemistry, 279(31), pp. 32904-32912. ISSN (print) 0021-9258

Leys, David, Basran, Jaswir, Talfournier, François, Kamaldeep, K. Chohan, Munro, Andrew, W., Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2004) Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: The trimethylamine dehydrogenase-electron- transferring flavoprotein complex. Biochemical Society Symposia, 71, pp. 1-14. ISSN (print) 0067-8694

Masgrau, Laura, Basran, Jaswir, Hothi, Parvinder, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2004) Hydrogen tunneling in quinoproteins. Archives of Biochemistry and Biophysics, 428(1), pp. 41-51. ISSN (print) 0003-9861

de Groot, Marcel, J., Kirton, Stewart, B. and Sutcliffe, Michael, J. (2004) In silico methods for predicting ligand binding determinants of cytochromes P450. Current Topics In Medicinal Chemistry, 4(16), pp. 1803-1824. ISSN (print) 1568-0266

Aubry, Carine, Jenkins, Paul, R., Mahale, Sachin, Chaduhuri, Bhabatosh, Maréchal, Jean-Didier and Sutcliffe, Michael, J. (2004) New fascaplysin-based CDK4-specific inhibitors: Design, synthesis and biological activity. Chemical Communications, 10(15), pp. 1696-1697. ISSN (print) 1359-7345

Flanagan, Jack, U., Maréchal, Jean-Didier, Ward, Richard, Kemp, Carol, A., McLaughlin, Lesley, A., Sutcliffe, Michael, J., Roberts, Gordon, C.K., Paine, Mark, J.I. and Wolf, C. Roland (2004) Phe120 contributes to the regiospecificity of cytochrome P450 2D6: Mutation leads to the formation of a novel dextromethorphan metabolite. Biochemical Journal, 380(2), pp. 353-360. ISSN (print) 0264-6021

Lawson, Rachel, W., Leys, David, Sutcliffe, Michael, J., Kemp, Carol, A., Cheesman, Myles, R., Smith, Susan, J., Clarkson, John, Smith, W. Ewen, Haq, Ihtshamul and Perkins, John, B. (2004) Thermodynamic and biophysical characterization of cytochrome P450 bioI from Bacillus subtilis. Biochemistry, 43(39), pp. 12410-12426. ISSN (print) 0006-2960

Kemp, Carol, A., Flanagan, Jack, U., van Eldik, Annamaria, J., Maréchal, Jean-Didier, Wolf, C. Roland, Roberts, Gordon, C.K., Paine, Mark, J.I. and Sutcliffe, Michael, J. (2004) Validation of model of cytochrome P450 2D6: An in silico tool for predicting metabolism and inhibition. Journal of Medicinal Chemistry, 47(22), pp. 5340-5346. ISSN (print) 0022-2623

Sutcliffe, Michael, J. (2004) A copper-bottomed trafficking solution. Structure, 12(4), pp. 517-518. ISSN (print) 0969-2126

Munro, A.W., McLean, K.J., Marshall, K.R., Warman, A.J., Lewis, G., Roitel, O., Sutcliffe, M.J., Kemp, C.A., Modi, S., Scrutton, N.S. and Leys, David (2003) Cytochromes P450: Novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis. Biochemical Society Transactions, 31(3), pp. 625-630. ISSN (print) 0300-5127

Hothi, Parvinder, Basran, Jaswir, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2003) Effects of multiple ligand binding on kinetic isotope effects in PQQ-dependent methanol dehydrogenase. Biochemistry, 42(13), pp. 3966-3978. ISSN (print) 0006-2960

Leys, David, Basran, Jaswir, Talfournier, François, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2003) Extensive conformational sampling in a ternary electron transfer complex. Nature Structural Biology, 10(3), pp. 219-225. ISSN (print) 1545-9993

Basran, Jaswir, Harris, Richard, J., Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2003) H-tunneling in the Multiple H-transfers of the Catalytic Cycle of Morphinone Reductase and in the Reductive Half-reaction of the Homologous Pentaerythritol Tetranitrate Reductase. The Journal of Biological Chemistry, 278(45), pp. 43973-43982. ISSN (print) 0021-9258

Paine, Mark, J.I., McLaughlin, Lesley, A., Flanagan, Jack, U., Kemp, Carol, A., Sutcliffe, Michael, J., Roberts, Gordon, C.K. and Wolf, C. Roland (2003) Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. The Journal of Biological Chemistry, 278(6), pp. 4021-4027. ISSN (print) 0021-9258

Flanagan, Jack, U., McLaughlin, Lesley, A., Paine, Mark, J.I., Sutcliffe, Michael, J., Roberts, Gordon, C.K. and Wolf, C. Roland (2003) Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. Biochemical Journal, 370(3), pp. 921-926. ISSN (print) 0264-6021

Stanfield, Peter, R. and Sutcliffe, Michael, J. (2003) Spermine Is Fit to Block Inward Rectifier (Kir) Channels. Journal of General Physiology, 122(5), pp. 481-484. ISSN (print) 0022-1295

Kirton, Stewart, B., Baxter, Carol, A. and Sutcliffe, Michael, J. (2002) Comparative modelling of cytochromes P450. Advanced Drug Delivery Reviews, 54(3), pp. 385-406. ISSN (print) 0169-409X

Jones, Matthew, Talfournier, Francois, Bobrov, Anton, Grossmann, J. Günter, Vekshin, Nikolai, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2002) Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein. The Journal of Biological Chemistry, 277(10), pp. 8457-8465. ISSN (print) 0021-9258

Kirton, Stewart, B., Kemp, Carol, A., Tomkinson, Nicholas, P., St. Gallay, Steven and Sutcliffe, Michael, J. (2002) Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6. Proteins: Structure, Function and Genetics, 49(2), pp. 216-231. ISSN (online) 1097-0134

Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2002) A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes. European Journal of Biochemistry, 269(13), pp. 3096-3102. ISSN (print) 1742-464X

Basran, Jaswir, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2001) Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase: Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes. The Journal of Biological Chemistry, 276(27), pp. 24581-24587. ISSN (print) 0021-9258

Lloyd Raven, E., Celik, A., Cullis, P.M., Sangar, R. and Sutcliffe, M.J. (2001) Engineering the active site of ascorbate peroxidase. Biochemical Society Transactions, 29(2), pp. 105-111. ISSN (print) 0300-5127

Basran, Jaswir, Patel, Shila, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2001) Importance of barrier shape in enzyme-catalyzed reactions: Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent amine dehydrogenases. The Journal of Biological Chemistry, 276(9), pp. 6234-6242. ISSN (print) 0021-9258

So, I., Ashmole, I., Davies, N.W., Sutcliffe, M.J. and Stanfield, P.R. (2001) The K+ channel signature sequence of murine Kir2.1: Mutations that affect microscopic gating but not ionic selectivity. Journal of Physiology, 531(1), pp. 37-50. ISSN (print) 0928-4257

Basran, Jaswir, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2001) Optimizing the Michaelis complex of trimethylamine dehydrogenase: Identification of interactions that perturb the ionization of substrate and facilitate catalysis with trimethylamine base. The Journal of Biological Chemistry, 276(46), pp. 42887-42892. ISSN (print) 0021-9258

Chohan, Kamaldeep, K., Jones, Matthew, Grossmann, J. Günter, Frerman, Frank, E., Scrutton, Nigel, S. and Sutcliffe, Michael, J. (2001) Protein Dynamics Enhance Electronic Coupling in Electron Transfer Complexes. The Journal of Biological Chemistry, 276(36), pp. 34142-34147. ISSN (print) 0021-9258

Faulder, Paul, F., Tresadern, Gary, Chohan, Kamaldeep, K., Scrutton, Nigel, S., Sutcliffe, Michael, J., Hillier, Ian, H. and Burton, Neil, A. (2001) QM/MM studies show substantial tunneling for the hydrogen-transfer reaction in methylamine dehydrogenase 6. Journal of the American Chemical Society, 123(35), pp. 8604-8605. ISSN (print) 0002-7863

Fowler, Stephen, M., Riley, Robert, J., Pritchard, Michael, P., Sutcliffe, Michael, J., Friedberg, Thomas and Wolf, C. Roland (2000) Amino acid 305 determines catalytic center accessibility in CYP3A4. Biochemistry, 39(15), pp. 4406-4414. ISSN (print) 0006-2960

Basran, Jaswir, Chohan, Kamaldeep, K., Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2000) Differential coupling through Val-344 and Tyr-442 of trimethylamine dehydrogenase in electron transfer reactions with ferricenium ions and electron transferring flavoprotein. Biochemistry, 39(31), pp. 9188-9200. ISSN (print) 0006-2960

Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2000) Enzyme catalysis: Over-the-barrier or through-the-barrier? Trends in Biochemical Sciences, 25(9), pp. 405-408. ISSN (print) 0968-0004

Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2000) Enzymology takes a quantum leap forward. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 358(1766), pp. 367-386. ISSN (print) 1364-503X

Harris, Richard J., Meskys, Rolandas, Sutcliffe, Michael J. and Scrutton, Nigel S. (2000) Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp. 1-IN. Biochemistry, 39(6), pp. 1189-1198. ISSN (print) 0006-2960

Thompson, G.A., Leyland, M.L., Ashmole, I., Sutcliffe, M.J. and Stanfield, P.R. (2000) Residues beyond the selectivity filter of the K+ channel Kir2.1 regulate permeation and block by external Rb+ and Cs+. Journal of Physiology, 526(2), pp. 231-240. ISSN (print) 0022-3751

Trickey, Peter, Basran, Jaswir, Lian, Lu-Yun, Chen, Zhi-Wei, Barton, John, D., Sutcliffe, Michael, J., Scrutton, Nigel, S. and Matthews, F. Scott (2000) Structural and biochemical characterization of recombinant wild type and a C30A mutant of Trimethylamine dehydrogenase from Methylophilus methylotrophus (sp. W3A1). Biochemistry, 39(26), pp. 7678-7688. ISSN (print) 0006-2960

Chohan, Kamaldeep, K., Wo, Galen, Oswald, Robert, E. and Sutcliffe, Michael, J. (2000) Structural insights into NMDA ionotropic glutamate receptors via molecular modelling. Journal of Molecular Modeling, 6(1), pp. 16-25. ISSN (print) 0949-183X

Jones, Matthew, Basran, Jaswir, Sutcliffe, Michael, J., Grossmann, J. Günter and Scrutton, Nigel, S. (2000) X-ray scattering studies of Methylophilus methylotrophus (sp. W3a1) electron-transferring flavoprotein: Evidence for multiple conformational states and an induced fit mechanism for assembly with trimethylamine dehydrogenase. The Journal of Biological Chemistry, 275(28), pp. 21349-21354. ISSN (print) 0021-9258

Wo, Z. Galen, Chohan, Kamaldeep K., Chen, Haiying, Sutcliffe, Michael J. and Oswald, Robert E. (1999) Cysteine mutagenesis and homology modeling of the ligand-binding site of a kainate-binding protein. The Journal of Biological Chemistry, 274(52), pp. 37210-37218. ISSN (print) 0021-9258

Scrutton, N.S., Basran, J., Wilson, E.K., Chohan, K.K., Jang, M.-H., Sutcliffe, M.J. and Hille, R. (1999) Electron transfer in trimethylamine dehydrogenase and electron-transferring flavoprotein. Biochemical Society Transactions, 27(2), pp. 196-201. ISSN (print) 0300-5127

Basran, Jaswir, Sutcliffe, Michael J. and Scrutton, Nigel S. (1999) Enzymatic H-transfer requires vibration-driven extreme tunneling. Biochemistry, 38(10), pp. 3218-3222. ISSN (print) 0006-2960

Scrutton, Nigel S., Basran, Jaswir and Sutcliffe, Michael J. (1999) New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics. The FEBS Journal, 264(3), pp. 666-671. ISSN (print) 1742-464X

Basran, Jaswir, Sutcliffe, Michael, J., Hille, Russ and Scrutton, Nigel, S. (1999) Reductive half-reaction of the H172Q mutant of trimethylamine dehydrogenase: Evidence against a carbanion mechanism and assignment of kinetically influential ionizations in the enzyme-substrate complex. Biochemical Journal, 341(2), pp. 307-314. ISSN (print) 0264-6021

Sutcliffe, Michael J., Smeeton, Allister H., Wo, Z Galen and Oswald, Robert E. (1999) Three-dimensional models of glutamate receptors. Faraday Discussions, 111, pp. 259-272. ISSN (print) 1359-6640

Dart, C., Leyland, M.L., Spencer, P.J., Stanfield, P.R. and Sutcliffe, M.J. (1999) Topology of the pore region of an inward rectifier K+ channel, Kir2.1. Annals of the New York Academy of Sciences, 868, pp. 414-417. ISSN (print) 0077-8923

Leyland, M.L., Dart, C., Spencer, P.J., Sutcliffe, M.J. and Stanfield, P.R. (1999) The possible role of a disulphide bond in forming functional Kir2.1 potassium channels. Pflugers Archiv European Journal of Physiology, 438(6), pp. 778-781. ISSN (print) 0031-6768

Cullis, Paul M., Merson-Davies, Louise, Weaver, Richard and Sutcliffe, Michael J. (1998) DNA alkylation sites of nitrogen mustards conjugated to polyamines and their implications for polyamine-DNA interactions. Chemical Communications, 16, pp. 1699-1700. ISSN (print) 1359-7345

Smith, Gillian, Modi, Sandeep, Pillai, Ilona, Lian, Lu-Yun, Sutcliffe, Michael J., Pritchard, Michael P., Freidberg, Thomas, Roberts, Gordon C.K. and Wolf, Roland (1998) Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: Design and construction of a mutant with testosterone hydroxylase activity. Biochemical Journal, 331(3), pp. 783-792. ISSN (print) 0300-5127

Guo, Wei, Sutcliffe, Michael J., Cerione, Richard A. and Oswald, Robert E. (1998) Identification of the binding surface on Cdc42Hs for p21-activated kinase. Biochemistry, 37(40), pp. 14030-14037. ISSN (print) 0006-2960

Chohan, K.K, Scrutton, N.S. and Sutcliffe, M.J. (1998) Major structural reorganisation most likely accompanies the transient formation of a physiological electron transfer complex. Protein and Peptide Letters, 5(4), pp. 231-236. ISSN (print) 0929-8665

Sutcliffe, Michael J., Smeeton, Allister H., Wo, Z. Galen and Oswald, Robert E. (1998) Molecular modeling of ligand-gated ion channels. Methods in Enzymology, 293, pp. 589-620. ISSN (print) 0076-6879

Ertughrul, O.W., Errington, N., Raza, S., Sutcliffe, M.J., Rowe, A.J. and Scrutton, N.S. (1998) Probing the stabilizing role of C-terminal residues in trimethylamine dehydrogenase. Protein Engineering Design & Selection, 11(6), pp. 447-455. ISSN (print) 1741-0126

Sutcliffe, M.J., Smeeton, A.H., Wo, Z.G. and Oswald, R.E. (1998) Three-dimensional models of glutamate receptors. Biochemical Society Transactions, 26(3), pp. 450-458. ISSN (print) 0300-5127

Dart, C., Leyland, M.L., Barrett-Jolley, R., Shelton, P.A., Spencer, P.J., Conley, E.C., Sutcliffe, M.J. and Stanfield, P.R. (1998) The dependence of Ag+ block of a potassium channel, murine Kir2.1, on a cysteine residue in the selectivity filter. The Journal of Physiology, 511(1), pp. 15-24. ISSN (print) 0022-3751

Dart, C., Leyland, M.L., Spencer, P.J., Stanfield, P.R. and Sutcliffe, M.J. (1998) The selectivity filter of a potassium channel, murine Kir2.1, investigated using scanning cysteine mutagenesis. Journal of Physiology, 511(1), pp. 25-32. ISSN (print) 0022-3751

Modi, S., Gilham, D.E., Sutcliffe, M.J., Lian, L.-Y., Primrose, W.U., Wolf, C.R. and Roberts, G.C.K. (1997) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: Allosteric effects of NADPH-cytochrome P450 reductase. Biochemistry, 36(15), pp. 4461-4470. ISSN (print) 0006-2960

Modi, S., Paine, M.J., Oliver, C.F., Smith, G., Sutcliffe, M.J., Gilhartr, D.E., Shaw, A.N.J., Lian, L.Y., Primrose, W.U., Wolf, C.R. and Roberts, G.C.K. (1997) Active site models of human cytochrome P450s based on NMR relaxation measurements. FASEB Journal, 11(9), A771. ISSN (print) 0892-6638

Roberts, G.C.K., Modi, S., Üilham, D.E. and Sutcliffe, M.J. (1997) Allostkric effects of cytochrome P450 reductase on cytochrome P450 2D6. FASEB Journal, 11(9), A789. ISSN (print) 0892-6638

Hill, Adrian P., Modi, Sandeep, Sutcliffe, Michael J., Turner, Daniel D., Gilfoyle, David J., Smith, Andrew T., Tam, Beatrice M. and Lloyd, Emma (1997) Chemical, spectroscopic and structural investigation of the substrate-binding site in ascorbate peroxidase. The FEBS Journal, 248(2), pp. 347-354. ISSN (print) 1742-464X

Roberts, G.C.K., Sutcliffe, Michael J., Modi, S., Lian, L.-Y., Primrose, W.U. and Wolf, C.R. (1997) Construction of models of P450-substrate complexes by a combination of NMR and homology modelling. FASEB Journal, 11(9), A778. ISSN (print) 0892-6638

Feltham, Joanna L., Dötsch, Volker, Raza, Sami, Manor, Danny, Cerione, Richard A., Sutcliffe, Michael J., Wagner, Gerhard and Oswald, Robert E. (1997) Definition of the switch surface in the solution structure of Cdc42Hs. Biochemistry, 36(29), pp. 8755-8766. ISSN (print) 0006-2960

Kelley, Lawrence A. and Sutcliffe, Michael J. (1997) OLDERADO: On-line database of ensemble representatives and domains. Protein Science, 6(12), pp. 2628-2630. ISSN (print) 0961-8368

Khan, Kishore Kumar, Mazumdar, Shyamalava, Modi, Sandeep, Sutcliffe, Mike, Roberts, Gordon C.K. and Mitra, Samaresh (1997) Steady-state and picosecond-time-resolved fluorescence studies on the recombinant heme domain of Bacillus megaterium cytochrome P-450. The FEBS Journal, 244(2), pp. 361-370. ISSN (print) 1742-464X

Kelley, L.A., Gardner, S.P. and Sutcliffe, M.J. (1997) An automated approach for defining core atoms and domains in an ensemble of NMR-derived protein structures. Protein Engineering Design & Selection (PEDS), 10(6), pp. 737-741. ISSN (print) 1741-0126

Wilson, Emma K., Huang, Liuxin, Sutcliffe, Michael J., Mathews, F. Scott, Hille, Russ and Scrutton, Nigel S. (1997) An exposed tyrosine on the surface of trimethylamine dehydrogenase facilitates electron transfer to electron transferring flavoprotein: Kinetics of transfer in wild-type and mutant complexes. Biochemistry, 36(1), pp. 41-48. ISSN (print) 0006-2960

Oliver, Catherine F., Modi, Sandeep, Sutcliffe, Michael J., Primrose, William U., Lian, Lu-Yun and Roberts, Gordon C.K. (1997) A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation. Biochemistry, 36(7), pp. 1567-1572. ISSN (print) 0006-2960

Morais Cabral, Joas H., Petosa, Carlo, Sutcliffe, Michael J., Raza, Sami, Byron, Olwyn, Poy, Florence, Marfatia, Shirin, Chishti, Athar H. and Liddington, Robert C. (1996) Crystal structure of a PDZ domai. Nature, 382(6592), pp. 649-652. ISSN (print) 0028-0836

Tozer, Eileen Collins, Liddington, Robert C., Sutcliffe, Michael J., Smeeton, Allister H. and Loftus, Joseph C. (1996) Ligand binding to integrin α(IIb)β3 is dependent on a MIDAS-like domain in the β3 subunit. The Journal of Biological Chemistry, 271(36), pp. 21978-21984. ISSN (print) 0021-9258

Atkinson, Robert S., Barker, Emma and Sutcliffe, Michael J. (1996) N-Acetyl-N-acyl-3-aminoquinazolinones as chemoselective acetylating agents. Chemical Communications, 9, pp. 1051-1052. ISSN (print) 1359-7345

Ramesh, Vasudevan, Syed, Shabith E.H., Frederick, Ronnie O., Sutcliffe, Michael J., Barnes, Maria and Roberts, Gordon C.K. (1996) NMR studies of the mode of binding of corepressors and inducers to Escherichia coli trp repressor. The FEBS Journal, 235(3), pp. 804-813. ISSN (print) 1742-464X

Sutcliffe, M.J., Wo, Z.G. and Oswald, R.E. (1996) Three-dimensional models of non-NMDA glutamate receptors. Biophysical Journal, 70(4), pp. 1575-1589. ISSN (print) 0006-3495

Kelley, Lawrence A., Gardner, Stephen P. and Sutcliffe, Michael J. (1996) An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies. Protein Engineering, Design & Selection, 9(11), pp. 1063-1065. ISSN (print) 1741-0126

Modi, Sandeep, Sutcliffe, Michael, Primrose, William U., Lian, Lu-Yun and Roberts, Gordon C.K. (1996) The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction. Nature Structural Biology, 3(5), pp. 414-417. ISSN (print) 1545-9993

Modi, S., Paine, M.J., Sutcliffe, M.J., Lian, L.-Y., Primrose, W.U. and Wolf, C.R. (1996) A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding. Biochemistry, 35(14), pp. 4540-4550. ISSN (print) 0006-2960

Murray, Iain A., Cann, Pauline A., Day, Philip J., Derrick, Jeremy P., Sutcliffe, Michael J., Shaw, William V. and Leslie, Andrew G.W. (1995) Steroid recognition by chloramphenicol acetyltransferase: Engineering and structural analysis of a high affinity fusidic acid binding site. Journal of Molecular Biology, 254(5), pp. 993-1005. ISSN (print) 0022-2836

Jaseja, Mahesh, Lu, Xinjie, Williams, Janice A., Sutcliffe, Michael J., Kakkar, Vijay V., Parslow, Rosemary A. and Hyde, Eva I. (1994) 1H-NMR assignments and secondary structure of dendroaspin, an RGD-containing glycoprotein IIb-IIIb (αIIb-β3) antagonist with a neurotoxin fold. The FEBS Journal, 226(3), pp. 861-868. ISSN (print) 1742-464X

Bagshaw, Clive R. and Sutcliffe, Michael J. (1994) Another turn for E-F hands. Nature Structural & Molecular Biology, 1(4), pp. 209-212. ISSN (print) 1545-9993

Sutcliffe, M.J., Feltham, J., Cerione, R.A. and Oswald, R.E. (1994) Model building predicts an additional conformational switch when GTP binds to the Cdc42HS protein. Protein and Peptide Letters, 1(2), pp. 84-91. ISSN (print) 0929-8665

Sutcliffe, M.J. and Stanfield, P.R. (1994) Pore region of K+ channel RACTK1 9. Nature, 369(6482), p. 616. ISSN (print) 0028-0836

Sutcliffe, Michael J., Jaseja, Mahesh, Hyde, Eva I., Lu, Xinjie and Williams, Janice A. (1994) Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin. Nature Structural & Molecular Biology, 1(11), pp. 802-807. ISSN (print) 1545-9993

Stanfield, P.R., Davies, N.W., Shelton, P.A., Sutcliffe, M.J., Khan, I.A., Brammar, W.J. and Conley, E.C. (1994) A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1. The Journal of Physiology, 478(1), pp. 1-6. ISSN (print) 0022-3751

Sutcliffe, Michael (1993) Representing an ensemble of NMR-derived protein structures by a single structure. Protein Science, 2(6), pp. 936-944. ISSN (print) 0961-8368

Sutcliffe, Michael J. (1993) Representing an ensemble of NMR-derived protein structures by a single structure. Protein Science, 2(6), pp. 936-944. ISSN (print) 0961-8368

Derrick, J.P., Wigley, D.B., Lian, L.Y., Sutcliffe, M.J., Yang, J.C., Dawson, P.D., Roberts, G.C.K. and , (1993) Structure and mechanism of Streptococcal protein G. Biochemical Society Transactions, 21(4), 333S. ISSN (print) 0300-5127

Derrick, Jeremy P., Wigley, Dale B., Lian, Lu-Yun, Sutcliffe, Michael J., Yang, Ji-Chun, Dawson, Philip D. and Roberts, Gordon C. (1993) Structure and mechanism of Streptococcal protein G. Biochemical Society Transactions, 21(4), 333S. ISSN (print) 0300-5127

Smith, Lorna J., Sutcliffe, Michael J., Redfield, Christina and Dobson, Christopher M. (1993) Structure of hen lysozyme in solution. Journal of Molecular Biology, 229(4), pp. 930-944. ISSN (print) 0022-2836

Smith, Lorna J., Sutcliffe, Michael J., Redfield, Christina and Dobson, Christopher M. (1993) Structure of hen lysozyme in solution. Journal of Molecular Biology, 229(4), pp. 930-944. ISSN (print) 0022-2836

Lian, L.Y., Derrick, J.P., Sutcliffe, M.J., Yang, J.C. and Roberts, G.C.K. (1992) Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance. Journal of Molecular Biology, 228(4), pp. 1219-1234. ISSN (print) 0022-2836

Lian, L.Y., Derrick, J.P., Sutcliffe, M.J., Yang, J.C. and Roberts, G.C.K. (1992) Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance. Journal of Molecular Biology, 228(4), pp. 1219-1234. ISSN (print) 0022-2836

Li, Xiang, Sutcliffe, Michael, J., Schwartz, Thue, W. and Dobson, Christopher, M. (1992) Sequence-specific 1H NMR assignments and solution structure of bovine pancreatic polypeptide. Biochemistry, 31(4), pp. 1245-1253. ISSN (print) 0006-2960

Li, Xiang, Sutcliffe, Michael, Schwartz, Thue W. and Dobson, Christopher M. (1992) Sequence-specific 1H NMR assignments and solution structure of bovine pancreatic polypeptide. Biochemistry, 31(4), pp. 1245-1253. ISSN (print) 0006-2960

Sutcliffe, Michael, J., Dobson, Christopher, M. and Oswald, Robert, E. (1992) Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: Calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. Biochemistry, 31(11), pp. 2962-2970. ISSN (print) 0006-2960

Sutcliffe, Michael J., Dobson, Christopher M. and Oswald, Robert E. (1992) Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: Calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. Biochemistry, 31(11), pp. 2962-2970. ISSN (print) 0006-2960

Smith, Lorna J., Sutcliffe, Michael J., Redfield, Chrsitina and Dobson, Christopher M. (1991) Analysis of .vphi. and .chi.1 torsion angles for Hen Lysozyme in Solution from proton NMR Spin-Spin Coupling Constants. Biochemistry, 30(4), pp. 986-996. ISSN (print) 0006-2960

Sutcliffe, Michael J. and Dobson, Chrsitpher M. (1991) Relaxation data in NMR structure determination: Model calculations for the lysozyme-Gd3+ complex. Proteins: Structure, Function and Bioinformatics, 10(2), pp. 117-129. ISSN (online) 1097-0134

Oswald, Robert, E., Sutcliffe, Michael, J., Bamberger, Michelle, Loring, Ralph, H., Braswell, Emory and Dobson, Christopher, M. (1991) Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: Sequence-specific assignments, secondary structure, and dimer formation. Biochemistry, 30(20), pp. 4901-4909. ISSN (print) 0006-2960

Oswald, Robert, E., Sutcliffe, Michael, J., Bamberger, Michelle, Loring, Ralph, H., Braswell, Emory and Dobson, Christopher, M. (1991) Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: Sequence-specific assignments, secondary structure, and dimer formation. Biochemistry, 30(20), pp. 4901-4909. ISSN (print) 0006-2960

Johnson, Mark S., Sutcliffe, Michael J. and Blundell, Tom L. (1990) Molecular anatomy: Phyletic relationships derived from three-dimensional structures of proteins. Journal of Molecular Evolution, 30(1), pp. 43-59. ISSN (print) 0022-2844

Blundell, Tom, Carney, Devon, Gardner, Stephen, Hayes, Fiona, Hubbard, Tim, Overington, John, Singh, Diljeet Athwal, Sibanda, Bancinyane Lynn and Sutcliffe, Michael (1988) 18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design. Febs Journal, 172(3), pp. 513-520. ISSN (print) 1742-464X

Blundell, Tom, Carney, Devon, Gardner, Stephen, Hayes, Fiona, Howlin, Brendan, Hubbard, Tim, Overington, John, Singh, Diljeet A., Sibanda, Bancinyane L. and Sutcliffe, Michael (1988) 18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design. European Journal of Biochemistry, 172(3), pp. 513-520. ISSN (print) 1742-464X

Sutcliffe, M.J., Haneef, I. and Blundell, T.L. (1987) Knowledge based modelling of homologous proteins, part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. Protein Engineering Design & Selection (PEDS), 1(5), pp. 377-384. ISSN (print) 1741-0126

Sutcliffe, Michael J., Haneef, I and Blundell, T.L. (1987) Knowledge based modelling of homologous proteins, part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. Protein Engineering Design & Selection (PEDS), 1(5), pp. 377-384. ISSN (print) 1741-0126

Sutcliffe, M.J., Hayes, F.R.F. and Blundell, T.L. (1987) Knowledge based modelling of homologous proteins, part II: Rules for the conformations of substituted sidechains. Protein Engineering Design & Selection (PEDS), 1(5), pp. 385-392. ISSN (print) 1741-0126

Sutcliffe, M.J., Hayes, F.R.F. and Blundell, T.L. (1987) Knowledge based modelling of homologous proteins, part II: Rules for the conformations of substituted sidechains. Protein Engineering Design & Selection (PEDS), 1(5), pp. 385-392. ISSN (print) 1741-0126

Book Section

Kirton, Stewart, B., Stansfeld, Phillip, J., Mitcheson, John, S. and Sutcliffe, Michael, J. (2007) Homology Models Applied to Toxicology. In: Ekins, Sean, (ed.) Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals. Hoboken, New Jersey, U.S.A. : John Wiley & Sons, Inc. pp. 433-468.

Basran, Jaswir, Masgrau, Laura, Sutcliffe, Michael, J. and Scrutton, Nigel, S. (2007) Hydrogen Tunneling in Enzyme-Catalyzed Hydrogen Transfer: Aspects from Flavoprotein Catalysed Reactions. In: Hynes, J. T. , Klinman, J. P. , Limbach, H.-H. and Schowen, R. L., (eds.) Hydrogen-Transfer Reactions. Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA. pp. 1341-1359. ISBN 9783527611546

Scrutton, Nigel S. and Sutcliffe, Michael J. (2000) Trimethylamine dehydrogenase and electron transferring flavoprotein. In: Holzenburg, Andreas and Scrutton, Nigel S., (eds.) Enzyme-Catalyzed Electron and Radical Transfer. Springer US. pp. 145-181. (Subcellular Biochemistry, no. 35) ISBN 9780306463990

Lian, L.Y., Barsukov, I.L., Sutcliffe, M.J., Sze, K.H. and Roberts, G.C.K. (1994) Protein-ligand interactions: Exchange processes and determination of ligand conformation and protein-ligand contacts. In: James, Thomas L. and Oppenheimer, Norman J., (eds.) Nuclear Magnetic Resonance, Part C. Elsevier. pp. 657-700. (Methods in Enzymology, no. 239) ISBN 9780121821401

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