Professor Nader Al-Dewik
Faculties, departments and locations
- Faculty of Health, Science, Social Care and Education
- Penrhyn Road
Associate Professor
- Email:
- [email protected]
About
Dr. Al-Dewik is a Director of Translational and Precision Medicine Research, Principal Investigator at Hamad Medical Corporation (HMC), and A/Professor in Human Genetics, Genomic and Precision Medicine Program, College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU) in the State of Qatar.
As a key principal investigator, Dr. Al-Dewik has successfully gained several research grants funded by different funding bodies and secured up to USD 9 M between 2008 and 2023 through collaboration with several international teams on translational molecular genetics and precision medicine projects. His major research interests are in addressing high-priority maternal and neonatal health, such as inherited genetic disorders, congenital anomalies, cancer/leukaemia, and preterm babies.
He was also awarded an innovation fund from Qatar Science and Technology Park (QSTP) to develop a molecular kit. Dr. Al-Dewik's approach is multidisciplinary and collaborative in nature.
Dr. Al-Dewik has presented original research findings at several local, regional, and international conferences and published them in peer-reviewed journals. He has published over 50 articles in peer-reviewed journals, book chapters, and abstracts. He is acting as a reviewer for many cancer and genetics journals.
Dr. Al-Dewik is also a reviewer of research grant proposals such as The Research Council (TRC) of the Sultanate of Oman and Qatar University Internal Grants.
Dr. Al-Dewik is a managing editor of Frontiers in Bioscience special issues, academic editor of PLOS ONE, and Ad Hoc reviewer for the BMJ, PLOS ONE, the Molecular Cancer, BMC, Springer Nature, Journal of Translational Medicine, BMC, Springer Nature, the Epigenetics Taylor & Francis, Journal of Pediatric Genetics, Metagene Elsevier Journal, the Journal of Cancer Therapy (JCT), Biomarkers in Cancer, Bioinformatics and Biology Insights Journal, Cancer Informatics Journal.
Qualifications
- Postgraduate Award: Cancer Biology & Therapeutics (CBT) program (Harvard Medical School HMS - 2016)
- PhD Biomedical Sciences – Molecular Biology and Human Genetics (Kingston University of London and St George's Medical School - 2012)
- MSc Medical Laboratory Sciences (Faculty of Medicine, the University of Jordan - 2003)
Domains
- Cellular and Molecular Basis of Disease (BIOM 710)
- Molecular Basis of Disease (BIOL619)
- Special Topics (BIOM 401)
- Introduction to Molecular diagnostic (BIOM515)
- Medical and Human Genetics, Genetic counselling program (GENC 612)
- Advanced Haematology (BIOM681)
- Molecular Diagnostics (BIOM 515)
- Medical Molecular Biology (BIOM 320)
- The Human Genetics (BIOM 217)
- Clinical Laboratory Methodologies (BIOM 402)
Research Funding (Total funding successfully obtained: $7,933,440)
2020-2023
Exploiting yeast and tissue culture models for studying classical and novel CBS mutations toward developing a novel therapy for Homocystinuria, Lead Investigator (L-PI). Medical Research Centre, Internal Research Grant Cycle, IRGC-06-SI-19-167, Senior investigator category, $211,538.46
2019-2022
Studying EpiGene expression changes of Post-Traumatic Stress Disorders (PTSD) in the state of Qatar, L-PI. Medical Research Centre, Hamad Medical Corporation (MRC-HMC: MRC-01-19-288), $35,000
2019-2021
Studying risk factors and comorbid conditions in neurobehavioral disorders in the state of Qatar for neurobehavioral disorders in the state of Qatar, L-PI. MRC-HMC: MRC-01-18-280, $30,000
2019
Whole Exome Sequencing to Identify Disease Genes in Jordanian Patients with Global Developmental Delay, Consultant/advisor. Jordan University of Science and Technology (JUST), $9,000
2019
Profiling of Chronic Myeloid Neoplasms through Gene Expression and Long Non-Coding RNA (LncRNAs) Array, Industry Research Mentor. Qatar National Research Fund (QNRF) - The Undergraduate Research Experience Program (UREP) UREP20-093-3-028, $15,000
2020
Novel therapies for Qatar patients with Homocystinuria, PI.QNRF - National Priorities Research Program (NPRP), NPRP7 - 355 - 3 – 088, $822,030
2019
Premature Children in Qatar and the UK: Disability, Cognitive, Eating and Behaviour Development. NPRP6 - 397 - 3 - 105, $900,000
Continuous Trauma and PTSD in Qatar and the Gaza Strip: Risk Factors and Causes, Consequences and Resiliency Factors. NPRP6 - 1283 - 3 - 30, $862,553
Development of an Absolute quantification kit for CALR types 1 and 2 mutations in Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) patients, LPI. QIPA1 0908-14039, $ 100,000
Exome Sequencing in Patients from Qatar and other Arab Countries to Improve Diagnosis of White Matter Diseases, PI. NPRP6 - 1463 - 3 – 351, $ 1,049,000
Specialisms
- Genetics and Genomics
- Epigenetics
- Precision medicine
Research student supervision
Current Graduate-level (Ph.D.) students
Mohamed Ismail, Noora Younes, Duaa Al-Sadeq, Dalal Alsharshani
Current Graduate level (MSc)
Sara Jemmieh, Shaza Alkhidir, Dima Alasmar
Previous Graduate level (MSc)
Fatma Alzayra, Samar Shurbaji, Foziyeh Naji, Abeer Mahdi, Abeer Qush, Dalal Alsharshani, Munira A. Aden, Zenat M. Kanfosh, Kholoud Aljassim, Mohammed Alsharshani, Mashael Al-Badr.
Previous Undergraduate level (BSc):
Salsabel Elshami and Nada Nasser
Industry links
- https://www.hamad.qa/EN/news/2023/January/Pages/New-Translational-and-Precision-Medicine-Research-Lab-Established-in-WWRC.aspx
- https://m.thepeninsulaqatar.com/article/07/01/2023/new-translational-and-precision-medicine-research-lab-established-in-wwrc
- https://www.qatar-tribune.com/article/54944/nation/preterm-precision-medicine-research-clinic-opens-at-wwrc
- https://www.qna.org.qa/en/News%20Area/News/2023-01/07/0011-new-translational,-precision-medicine-research-lab-established-in-wwrc
- https://www.gulf-times.com/story/579928/QU-health-students-discover-novel-approach-to-trea
- https://thepeninsulaqatar.com/article/22/11/2017/WISH-HMC-develop-new-technique-to-diagnose-blood-cancer
- https://mediaview.aljazeera.com/video/ONM3J4ZvoB
- https://www.youtube.com/watch?v=ftfRM7faGIg&t=275s
- https://youtu.be/-DsBvixiLzA
- https://www.hamad.qa/EN/All-Events/2QAIC2023/Speakers/Moderators/Pages/default.aspx
Publications
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Al‐Sharshani, Dalal, Velayutham, Dinesh, Samara, Muthanna, Gazal, Reham, Al Haj Zen, Ayman, Ismail, Mohamed A., Ahmed, Mahmoud, Nasrallah, Gheyath, Younes, Salma, Rizk, Nasser, Hammuda, Sara, Qoronfleh, M. Walid, Farrell, Thomas, Zayed, Hatem, Abdulrouf, Palli Valapila, AlDweik, Manar, Silang, John Paul Ben, Rahhal, Alaa, Al‐Jurf, Rana, Mahfouz, Ahmed, Salam, Amar, Al Rifai, Hilal and Al-Dewik, Nader I., 2023, pp e2178
Management of chronic myeloid leukaemia : current treatment options, challenges, and future strategies
Younes, Salma, Ismail, Mohamed A., Al-Jurf, Rana, Ziyada, Ayah, Nasrallah, Gheyath K., Abdulrouf, Palli Valapila, Nagy, Mohamed, Zayed, Hatem, Farrell, Thomas, Sorio, Claudio, Morsi, Hisham, Qoronfleh, M. Walid and Al-Dewik, Nader I., 2023, Hematology (28), 1
Prevalence, predictors, and outcomes of major congenital anomalies : a population-based register study
Al-Dewik, Nader, Samara, Muthanna, Younes, Salma, Al-jurf, Rana, Nasrallah, Gheyath, Al-Obaidly, Sawsan, Salama, Husam, Olukade, Tawa, Hammuda, Sara, Marlow, Neil, Ismail, Mohamed, Abu Nada, Taghreed, Qoronfleh, M. Walid, Thomas, Binny, Abdoh, Ghassan, Abdulrouf, Palli Valapila, Farrell, Thomas, Al Qubaisi, Mai and Al Rifai, Hilal, 2023, Scientific Reports (13), 1
Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors
Ismail, Mohamed A., Nasrallah, Gheyath K., Monne, Maria, AlSayab, Ali, Yassin, Mohamed A., Varadharaj, Govindarajulu, Younes, Salma, Sorio, Claudio, Cook, Richard, Modjtahedi, Helmout and Al-Dewik, Nader, 2022, Gene (813), pp 146101
Incidence, risk factors, and feto-maternal outcomes of inappropriate birth weight for gestational age among singleton live births in Qatar : a population-based study
Younes, Salma, Samara, Muthanna, Salama, Noor, Al-jurf, Rana, Nasrallah, Gheyath, Al-Obaidly, Sawsan, Salama, Husam, Olukade, Tawa, Hammuda, Sara, Abdoh, Ghassan, Abdulrouf, Palli Valapila, Farrell, Thomas, AlQubaisi, Mai, Al Rifai, Hilal and Al-Dewik, Nader, 2021, PLoS ONE (16), 10, pp e0258967
Incidence, risk factors, and outcomes of preterm and early term births : a population-based register study
Younes, Salma, Samara, Muthanna, Al-Jurf, Rana, Nasrallah, Gheyath, Al-Obaidly, Sawsan, Salama, Husam, Olukade, Tawa, Hammuda, Sara, Ismail, Mohamed A., Abdoh, Ghassan, Abdulrouf, Palli Valapila, Farrell, Thomas, AlQubaisi, Mai, Al Rifai, Hilal Al and Al-Dewik, Nader, 2021, International Journal of Environmental Research and Public Health (18), 11, pp e5865
Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
Ismail, Mohamed A., Vezzalini, Marzia, Morsi, Hisham, Abujaber, Ahmad, Al Sayab, Ali, Siveen, Kodappully, Yassin, Mohamed A., Monne, Maria, Samara, Muthanna, Cook, Richard, Sorio, Claudio, Modjtahedi, Helmout and Al-Dewik, Nader I., 2021, Scientific Reports (11), pp 8833
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the state of Qatar
Ismail, Mohamed A., Samara, Muthanna, Al Sayab, Ali, Alshashani, Mohamed, Yassin, Mohamed A., Varadharaj, Govindaraiulu, Vezzalini, Mariza, Tomasello, Luisa, Monne, Maria, Morsi, Hisham, Qoronfleh, M. Walid, Zayed, Hatem, Cook, Richard, Sorio, Claudio, Modjtahedi, Helmout and Al-Dewik, Nader I., 2020, Molecular Genetics and Genomic Medicine (8), 10, pp e1319
Effects of consanguinity in a cohort of subjects with certain genetic disorders in Qatar
Ben-Omran, Tawfeg, Al Ghanim, Kaltham, Yavarna, Tarunashree, El Akoum, Maha, Samara, Muthanna, Chandra, Prem and Al-Dewik, Nader, 2020, (8), 1, pp e1051
Children’s prolonged exposure to the toxic stress of war trauma in the Middle East
Samara, Muthanna, Hammuda, Sara, Vostanis, Panos, El-Khodary, Basel and Al-Dewik, Nader, 2020, British Medical Journal (BMJ) (371), pp m3155
Is adherence to Imatinib Mesylate treatment among patients with chronic myeloid leukemia associated with better clinical outcomes in Qatar?
Al-Dewik, Nader I, Morsi, Hisham M, Samara, Muthanna M, Ghasoub, Rola S, Gnanam, Cinquea C, Bhaskaran, Subi K, Nashwan, Abdulqadir J, Al-Jurf, Rana M, Ismail, Mohamed A, AlSharshani, Mohammed M, AlSayab, Ali A, Ben-Omran, Tawfeg I, Khatib, Rani B and Yassin, Mohamed A, 2016, Clinical Medicine Insights : Oncology (10), pp 95-104
Studying the impact of presence of alpha acid glycoprotein and protein glycoprotein in chronic myeloid leukemia patients treated with imatinib mesylate in the State of Qatar
Al-Dewik, Nader I, Jewell, Andrew P, Yassin, Mohammed A and Morsi, Hisham M, 2015, Biomarkers in Cancer (7), pp 63-67
Attention-deficit hyperactivity disorder : genetic, pharmacogenetic, and metabolomic insights
Younes, Salma N., Al-Jurf, Rana, Hammuda, Sara, Nasrallah, Gheyath K., Al-Jurf, Amal, Ziyada, Ayah, Abdulrouf, Palli Valapila, Qoronfleh, M. Walid, Samara, Muthanna and Al-Dewik, Nader (2022). In: Qoronfleh, M. Walid, (eds.), Essa, Musthafa Mohamed, (eds.) and Chidambaram, Saravana Babu, (eds.), Proteins associated with neurodevelopmental disorders. Singapore: Springer Singapore, pp 135-189
Principal molecular pathways affected in autism spectrum disorder
Younes, Salma N., Al-Jurf, Rana, Hammuda, Sara, Nasrallah, Gheyath K., Zayed, Hatem, Qoronfleh, M. Walid, Ismail, Mohamed A., Farrell, Tom, Al-Rifai, Hilal, Samara, Muthanna and Al-Dewik, Nader (2022). In: Qoronfleh, M. Walid, (eds.), Essa, Musthafa Mohamed, (eds.) and Chidambaram, Saravana Babu, (eds.), Proteins associated with neurodevelopmental disorders. Singapore: Springer Singapore, pp 1-47
New horizons for molecular genetics diagnostic and research in autism spectrum disorder
Al-Dewik, Nader and Alsharshani, Mohammed (2020). In: Essa, M. Mohamed, (eds.) and Qoronfleh, M. Walid, (eds.), Personalized food intervention and therapy for autism spectrum disorder management. Cham, Switzerland: Springer Nature, pp 43-81
Psychological comorbidities in autism spectrum disorders
Shaltout, Eman, Al-Dewik, Nader, Samara, Muthanna, Morsi, Hisham and Khattab, Azhar (2020). In: Essa, M. Mohamed, (eds.) and Qoronfleh, M. Walid, (eds.), Personalized food intervention and therapy for autism spectrum disorder management. Cham, Switzerland: Springer, pp 163-191
Mechanism(s) of resistance of Chronic Myelocytic Leukaemia (CML) to Glivec in a patient population in the State of Qatar
Al-Dewik, Nader (2012), PhD thesis, Kingston University