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Infection, Immunology and Cancer

  • Module code: PY6010
  • Year: 2018/9
  • Level: 6
  • Credits: 30
  • Pre-requisites: PY4010, PY4020, 0Y4030, PY4040 and PY5010
  • Co-requisites: None

Summary

This module addresses a number of core principles and concepts within the MPharm programme. It serves to develop knowledge of the immune system in health and disease including the use of vaccines. Infective agents and the science and practice of their control are investigated as well as cancer as a disease. The mechanisms of action and practical applications of chemotherapy are described together with novel drug targeting and palliative care. The delivery is via lectures supported by workshops integrating the different subject areas in case studies.

Aims

  • To develop knowledge of the immune system, how it works and how it can be modulated
  • To enhance knowledge of infective agents and the science and practice of their eradication
  • To develop enhanced knowledge of cancer as a class of diseases and the science and practice of treating cancer sufferers
  • To develop skills in scientific and clinical literature review

Learning outcomes

On successful completion of the module, students will be able to:

  • Discuss and critically evaluate the working of the immune system in health and disease
  • Discuss and critically evaluate the action of drugs, vaccines and other entities which modulate the immune system
  • Demonstrate a critical understanding between the mechanisms of action and modes of delivery of anti-infective agents and their use in practice
  • Describe and discuss cancer as a class of diseases and explore in detail mechanisms of action of chemotherapies, their benefits and problems, application in practice and novel targeting technologies
  • Produce a short literature critical review combining scientific and clinical themes

Curriculum content

  • Introduction to infection
  • Symbiotic human microbial flora - consequences of disruption
  • Uses of antibiotics, preservatives and disinfectants. Development of resistance
  • Sterilisation methods, asepsis and terminal sterility
  • Chemistry and mechanism of action of antibiotics, anti-virals and anti-fungals
  • Therapeutic monitoring of antimicrobials
  • Management of patients with HIV
  • Management of patients with conjunctivitis
  • Ophthalmic drug delivery
  • Immune system physiology
  • Forms of immunity
  • Properties of immunity and the immune response
  • T cells and cell-mediated immunity and B cells and antibody mediated  immunity
  • Primary and secondary responses to antigen exposure. Mediators of the immune system.
  • Autoimmune disorders, immunodeficiency diseases and allergies.
  • Immunosuppressants, immunomodulators: immunopharmacological and immunobiological agents in the prophylaxis, diagnosis, and treatment of common infectious and/or immunological diseases
  • Travellers' health
  • Anaemia and haematology
  • Introduction to cancer
  • Pharmacognosy of anti-cancer drugs
  • Chemistry and mechanism of action of drugs used to treat cancers
  • Drug resistance mechanisms in cancer
  • Novel drug targeting mechanisms for selective drug delivery
  • Clinical management of cancer patients
  • Febrile neutropenia
  • Palliative care of cancer patients
  • Health promotion for cancer prevention

Teaching and learning strategy

The majority of the material will be introduced by lectures which will be supported by directed reading from both textbook sources and journal articles. Workshops will be provided to allow students to explore specific examples from the lecture programme. These will be provided with "science into practice" case studies to illustrate how background sciences inform clinical practice. Science and practice laboratory practicals and simulations will be used to develop practical skills and competences as well as complement and consolidate lectures, workshops and directed reading. Online resources that include videos and podcasts will be uploaded onto the educational platform to supplement basic knowledge of immunology.

Breakdown of Teaching and Learning Hours

Definitive UNISTATS Category Indicative Description Hours
Scheduled learning and teaching Lectures Workshops Practical classes 45 25 40
Guided independent study 190
Total (number of credits x 10) 300

Assessment strategy

There is no end of module exam in this module

Summative assessment:

An in module assessment, comprising of an in class test, will be used to help students identify how they are progressing and act as an opportunity to give the students feedback. This assessment will also encourage student engagement with the module. The Assessment will consist of an MCQ/SBA section to test breadth of knowledge and application with a long (essay) answer section to test knowledge and critical appraisal in depth of a specific syllabus areas. The style of the assessment will also feed forward to the synoptic assessment that is a feature of this Level.

A short (2 page) literature review to write a short essay on a given topic linking current developments in science and clinical practice, integrating all 4 disciplines of Physiology/Pharmacology, Pharmaceutics, Pharmacy and Chemistry will be set to promote a deeper understanding of a drug's actions, the conditions it treats and the symptoms it relieves and unwanted effects it may elicit.  Topics will be supplied by the module team and students will be expected to locate suitable peer reviewed articles.  This experience of constructing a strong argument feeds forward to the literature review and project proposal for final year project, in addition to preparing the students for the synoptic assessment at the end of the year. As part of this assignment key milestone tasks being completed will contribute to the overall mark. These include completing an essay draft and submitting for formative review and feedback by peers as well as contributing to the peer review process. (see below).

Formative assessment:

 Workshop exercises will be self and peer marked to give students a view of their progress and food for reflection. These feed forward to the in module assessment as well as the synoptic assessment and synoptic OSCE.

Some workshops will have MCQ based mini-quizzes to support formative learning and encourage engagement with the module.

The literature review assignment will have two phases. The first is the preparation of a 'mock' literature review essay, in preparation for the summative essay will be completed and submitted before the Christmas break.  Feedback will be given on the essay plan and the nature of the content in workshops, during which student can address any issues.  Peer feedback will also highlight strengths and weaknesses in written communication of complex ideas by promoting reflection of another students work.

Both the formative and summative essays act to prepare the students for this end of year assessment. By integrating all 4 disciplines, the essays allow the perspective of the student to widen so that any one aspect of a disease or a drug can be thoroughly examined, promoting critical appraisal and rationalising drug prescription.

Feedback from practical and simulation results and data handling will be used to provide students with an ongoing assessment of their progress as well as the development of their skills and competence.

Level 6 MPharm students are required to pass a synoptic OSCE style assessment and a synoptic calculations test before they can progress to Level 7. These are to assure that even at this Level the student is demonstrating the appropriate skills, knowledge, understanding and attributes to become a future pharmacist.

In addition there is a synoptic exam covering the material in all four Level 6 modules, underpinned by learning from Levels 4 and 5. At level 6 the clinically themed modules have considerable cross module application and resonance to reflect the integrated nature of the course. To promote deeper learning, application and judgement as well as discourage silo learning a synoptic approach is more appropriate to assess the potential abilities of a future pharmacist. In addition it should facilitate in students the ability to ability to focus on a patient as a whole considering not only the prime condition but also co-morbidities.

Learning throughout this integrated module feeds forward into all three of these synoptic assessments, in particular using a variety of workshops and formative practical assessments that focus on calculations and every day prescription problem solving. In addition the summative assessment modes as described within the in-module assessment, will prepare the students for the synoptic assessments.

Mapping of Learning Outcomes to Assessment Strategy (Indicative)

Learning Outcome Assessment Strategy
1) Discuss and critically evaluate the working of the immune system in health and disease Formative in workshops and mini-quiz MCQs Summative: In class test
2) Discuss and critically evaluate the action of drugs, vaccines and other entities which modulate the immune system Formative in workshops Summative: In class test Literature review
3) Demonstrate a critical understanding of the relationship between the mechanisms of action and modes of delivery of anti-infective agents and their use in practice Formative in workshops and practicals Summative: In class test Literature review
4) Describe and discuss cancer as a class of diseases and explore in detail mechanisms of action of chemotherapies, their benefits and problems, application in practice and novel targeting technologies Formative: workshop, practicals Summative: In class test Literature review
5) Produce a short literature critical review combining scientific and clinical themes Formative in workshops Formative ‘mock' literature review Formative Peer review Summative: Literature review

Elements of Assessment

Description of Assessment Definitive UNISTATS Categories Percentage
Coursework Literature review 50%
Written exam In class test (In module assessment) 50%
Total (to equal 100%) 100%

Achieving a pass

It IS NOT a requirement that any element of assessment is passed separately in order to achieve an overall pass for the module.

Bibliography core texts

  • Patrick G.L., An Introduction to Medicinal Chemistry, Oxford University Press
  • Clayden, Greaves, Warren and Wothers - Organic Chemistry, Oxford University Press
  • Thomas G., Medicinal Chemistry - An Introduction, Wiley
  • Fischer et al (2003) The Cancer Chemotherapy Handbook. 6thEdition Mosby
  • Rang and Dale. Pharmacology, Churchill Livingstone
  • Drugs in Use: Clinical case studies for pharmacists (3rd ed) Dodds.
  • Pharmaceutical Press (2004). ISBN 0853695415
  • Clinical Pharmacy & Therapeutics (4th ed), Walker and Whittlesea. Churchill
  • Livingstone (2007). ISBN 0443102856
  • Pathology and therapeutics for pharmacists: A basis for clinical practice (3rd Ed),
  • Greene and Harris. Pharmaceutical Press, (2008). ISBN 978 0 85369 6902
  • British National Formulary, edited by the Joint Formulary Committee. Pharmaceutical Press.
  • MCQ in Clinical Pharmacy, L. M. Azzopardi. Pharmaceutical Press (2007). ISBN: 9780853696667

Bibliography recommended reading

  • Alberts, Bray, Lewis, Ralf, Roberts, Watson, Molecular Biology of the Cell, Garland Press,
  • Thomas G., Chemistry for Pharmacy and the Life Sciences, Prentice Hall.
  • Applied Therapeutics: The Clinical Use of Drugs (8th revised Ed) Koda-Kimble,
  • Young. Lippincott Williams and Wilkins, (2004). ISBN 0781748453
  • Clinical Pharmacy Survival Guide, Barber and Willson. Churchill Livingstone (1999) ISBN 085369754X
  • Stockley's Drug Interactions (8th ed) Stockley. Pharmaceutical Press (2007). ISBN0853695040
  • Meyler's Side Effects of Drugs (15th ed): The International Encyclopaedia of Adverse
  • Reactions and interactions (Meyler's Side Effects of Drugs), Aronson (2006). ISBN0444509984
  • Clinical pharmacokinetics: concepts and applications (3rd ed) Rowland. Williams & Wilkins (1995). ISBN 0683074040
  • ABC of monitoring drug therapy, Aronson, et al. BMJ books (1993). ISBN 0727907913
  • Clinical pharmacy pocket companion, Wright et al, Pharmaceutical Press (2006).ISBN: 9780853696490,
  • Concise clinical pharmacology, Greenstein, et al. Pharmaceutical Press (2006) ISBN: 9780853695769

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