This is a core module for Chemistry and M. Pharm. Sci degree courses, and is optional for the BSc. Pharm. Sci. Degree course. The module builds upon and develops further, topics introduced in the earlier level 5 module CH5002, for example, stereoselective synthesis and retrosynthetic analysis. In addition, new topics are introduced such as pharmacognosy, combinatorial chemistry, photochemistry, free radical chemistry and pericyclic reactions. The lectures and associated workshops will encourage the development of problem solving and team working skills, in order to prepare you for your future careers. These skills will be practised during laboratory-based exercises, where you will participate in group "mini-projects" which will be assessed using a range of methodologies that include oral presentations, report writing and poster presentations.
On successful completion of the module, students will be able to:
Two concurrent series of lectures (23 each) will be used to deliver the core material which will be supported by workshops. The workshops are intended to supplement and illustrate the lecture material, and to provide the student with an opportunity to clarify any aspects of the topics taught. The workshops will also provide opportunities for student to obtain feedback from staff regarding their progress. The practical sessions will provide an opportunity for team (group) work.
| Definitive UNISTATS Category | Indicative Description | Hours |
|---|---|---|
| Scheduled learning and teaching | 2 x 23 one-hour lectures 22 one-hour workshops 12 x 3-hour of practical sessions | 46 22 36 |
| Guided independent study | Recommended reading Formative assessment Summative assessment tasks Exam revision | 196 |
| Total (number of credits x 10) | 300 | |
Formative assessment of lectured material takes the form of workshop problems sheets. Summative assessment consists of a formal written examination, a group mini project and structured laboratory assessments. The examination consists of short and long answer questions from across the lecture syllabus. There is a revision assignment which is designed to help students prepare for the written examination, consisting of structured questions of the type encountered in the examination. A group mini project on as aspect of medicinal chemistry is prepared by students through the first and second semesters and presented orally in TB2. The practical course is assessed by a mixture of report sheets and a full report.
| Learning Outcome | Assessment Strategy |
|---|---|
| 1a) Identify different types of natural products isolated from various sources and describe their biological mode of action. 1b) Understand and explain some common biosynthetic pathways to terpenoid and opioid compounds. 1c) To develop team-work and problem- solving skills. | Formative assessment via problems set in workshops. Summative assessment by Practical summary sheets (TB2); Summative group mini-project on a natural product topic (oral presentation) and formative progress report (TB2); Summative structured questions on a Revision Assignment (TB2) as preparation to final written exam. Summative assessment in a section of end-of-module exam. |
| 2a) Apply semi-synthetic, retrosynthetic and stereoselective strategies to selected case studies within drug development. 2b) Describe pericyclic reactions; (cycloaddition reactions, electrocyclic reactions and sigmatropic rearrangements) in terms of their Frontier Orbital interactions. 2c) Understand free radical chemistry and photochemistry (in terms of fluorescence, phosphorescence, Jablonski diagrams etc), and be able to apply these in the synthesis of organic compounds. | Formative assessment opportunities will be provided via problems set in workshops. Summative assessment will be full practical report and summary sheets (TB1 and TB2). Summative assessment in section of end-of-module exam. |
| Description of Assessment | Definitive UNISTATS Categories | Percentage |
|---|---|---|
| Written exam | Written exam | 50% |
| Portfolio of coursework One full practical report TB1 (10%) Practical summary sheets TB1 (1) and TB2 (3) (total 10%) Revision assignment TB2 (10%) | Coursework | 30% |
| Oral presentation | Practical examination | 20% |
| Total (to equal 100%) | 100% | |
It IS NOT a requirement that any element of assessment is passed separately in order to achieve an overall pass for the module.
Organic Chemistry
Fessenden, R. J.; Fessenden J. S. (1998), Organic Chemistry, 6th Edition, Brooks/Cole
In conjunction with -Clayden, J.; Greeves, N.; Warren, S.; Wothers, P. (2012) Organic Chemistry, 2nd Edition, OUP
Medicinal Chemistry
Patrick, G. (2009) An Introduction to Medicinal Chemistry, 4th Edition OUP
Natural Products, Biosynthesis and Pharmacognosy
Derwick, P.M. (2009) Medicinal Natural Products: A Biosynthetic Approach. 3rd Edition, John Wiley and Sons Ltd, ISBN: 9780470741689
Photochemistry
To be announced; however the following contains an introduction to the topic:
March, J. (2007) Advanced Organic Chemistry, 6th Edition Wiley.
Sykes, P. (1996) A Guidebook to Mechanism in Organic Chemistry, 6th Edition, Prentice-Hall, ISBN 0582446953
Warren, S. (2009) Organic Synthesis: The Disconnection Approach, 2nd Edition Wiley.
Silverman, R. (2004) The Organic Chemistry of Drug Design and Drug Action, 2nd Edition, Academic Press.
Mann, J. (2004) Chemical Aspects of Biosynthesis, Reprinted OUP, ISBN: 019 855677