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Mr Simone Benedetti

Research project: Ethnic differences in appetite-regulatory hormones and risk markers for cardiovascular disease and type 2 diabetes in healthy South Asian and white European men

Abstract

South Asians represent the largest ethnic minority group in the UK and comprise individuals originating from the Indian subcontinent. It is well established that South Asians have an elevated risk of cardiovascular disease (CVD) and type 2 diabetes (T2D) both on the Indian subcontinent and after migration to Western nations. Furthermore, CVD and T2D manifest 5 to 10 years earlier and at a lower body mass index in South Asians, and are associated with premature complications and mortality compared to Europeans. The elevated risk of CVD and T2D in South Asians has been linked to the higher prevalence of insulin resistance and associated CVD risk factors including differences in adiposity, markers of inflammation, physical activity and fitness level. Several appetite-regulatory hormones have also been implicated in the short-term regulation of food intake, including acylated ghrelin and peptide YY (PYY). Therefore, the aim of this study is to investigate ethnic differences in traditional and novel risk markers for CVD and T2D in South Asian compared with European men and to assess how these markers relate to physical activity levels, cardiorespiratory fitness and food intake.

  • Research degree: PhD
  • Title of project: Ethnic differences in appetite-regulatory hormones and risk markers for cardiovascular disease and type 2 diabetes in healthy South Asian and white European men
  • Research supervisor: Dr Hannah Jayne Moir
  • Other research supervisor: Professor Declan Naughton

Biography

I earned a Bachelor's degree in Dietetics with a first class honours and a Master's degree in Human Nutrition Science with distinction from Tor Vergata University in Rome. I then moved to London where I was offered a fully funded PhD Scholarship in Sports Science by Kingston University. At present I am completing my final year of my PhD.

During my PhD I became experienced in conducting multiple physiological assessments including measurement of blood pressure, VO2max, wingate anaerobic test, body composition, and examination of different blood bio-markers (e.g. glucose, insulin, TOT-Chol, LDL, HDL, hormones etc.). In my current position as a PhD researcher I have also enriched my professional experiences by running laboratory demonstrations and by earning competency in venipuncture, cannulation, lipid extraction, gas chromatography analysis and DNA analysis (DNA extraction, genotyping, PCR). 

Areas of research interest

  • Exercise physiology and metabolic disorders
  • Sports and nutrition

Qualifications

  • BSc Dietetics
  • MSc Human Nutrition Science

Funding or awards received

  • Full time funded PhD Scholarship offered after approval of my research degree proposal by the Faculty Research Degrees Committee of Kingston University.
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