Professor Nader Al-Dewik

About

Dr. Al-Dewik is a Director of Translational Research, Principal Investigator in Hamad Medical Corporation (HMC) and A/Professor in Human Genetics, Genomic and Precision Medicine Program, College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU) in the State of Qatar.

As a key principal investigator, Dr. Al-Dewik has successfully gained several research grants funded by different funding bodies and secured up to USD$ 8 M between 2008 - 2021 through collaboration with several international teams on translational molecular genetics and precision medicine projects. His major research interests are in addressing high-priority maternal and neonatal health such as inherited genetic disorders, congenital anomalies, preterm babies.

He was also awarded an innovation fund from Qatar Science and Technology Park (QSTP) to develop a molecular kit. Dr. Al-Dewik's approach is multidisciplinary and collaborative in nature.

Dr. Al-Dewik has presented original research findings in several local, regional, and international conferences and published them in peer-reviewed journals. He has published more than 50 articles in peer-reviewed journals, book chapters, and abstracts. He is acting as a reviewer for many cancer and genetics journals.

Dr. Al-Dewik is also a reviewer of research grant proposals such as The Research Council (TRC) of the Sultanate of Oman and Qatar University Internal Grants.

Dr. Al-Dewik is a managing editor of Frontiers in Bioscience special issues along with Ad Hoc reviewer for the Molecular Cancer, BMC, Springer nature, Journal of Translational Medicine, BMC, Springer nature, the Epigenetics Taylor & Francis, Journal of Pediatric Genetics, Metagene Elsevier Journal, the Journal of Cancer Therapy (JCT), Biomarkers in Cancer, Bioinformatics and Biology Insights Journal, Cancer Informatics Journal.

Academic responsibilities

Associate Professor

Qualifications

  • Postgraduate Award: Cancer Biology & Therapeutics (CBT) program (Harvard Medical School HMS - 2016)
  • PhD Biomedical Sciences – Molecular Biology and Human Genetics (Kingston University of London and St George's Medical School - 2012)
  • MSc Medical Laboratory Sciences (Faculty of Medicine, the University of Jordan - 2003)

Teaching and learning

Cellular and Molecular Basis of Disease (BIOM 710) 

Molecular Basis of Disease (BIOL619)

Special Topics (BIOM 401)

Introduction to Molecular diagnostic (BIOM515)

Medical and Human Genetics, Genetic counseling program (GENC 612)

Advanced Hematology (BIOM681) 

Molecular Diagnostics (BIOM 515)

Medical Molecular Biology (BIOM 320) 

The Human Genetics (BIOM 217) 

Clinical Laboratory Methodologies (BIOM 402)

Research

Research Funding (Total funding successfully obtained: $7,933,440)

2020-2023

Exploiting yeast and tissue culture models for studying classical and novel CBS mutations toward developing a novel therapy for Homocystinuria, Lead Investigator (L-PI). Medical Research Center, Internal Research Grant Cycle, IRGC-06-SI-19-167, Senior investigator category, $211,538.46

2019-2022

Studying EpiGene expression changes of Post-Traumatic Stress Disorders (PTSD) in the state of Qatar, L-PI. Medical Research Centre, Hamad Medical Corporation (MRC-HMC: MRC-01-19-288), $35,000

2019-2021

Studying risk factors and comorbid conditions in neurobehavioral disorders in the state of Qatar for neurobehavioral disorders in the state of Qatar, L-PI. MRC-HMC: MRC-01-18-280, $30,000

2019

Whole Exome Sequencing to Identify Disease Genes in Jordanian Patients with Global Developmental Delay, Consultant/advisor. Jordan University of Science and Technology (JUST), $9,000

2019

Profiling of Chronic Myeloid Neoplasms through Gene Expression and Long Non-Coding RNA (LncRNAs) Array, Industry Research Mentor. Qatar National Research Fund (QNRF) - The Undergraduate Research Experience Program (UREP) UREP20-093-3-028, $15,000

2020

Novel therapies for Qatar patients with Homocystinuria, PI.QNRF - National Priorities Research Program (NPRP), NPRP7 - 355 - 3 – 088, $822,030

2019

Premature Children in Qatar and the UK: Disability, Cognitive, Eating and Behaviour Development. NPRP6 - 397 - 3 - 105, $900,000

Continuous Trauma and PTSD in Qatar and in the Gaza Strip: Risk Factors and Causes, Consequences and Resiliency Factors. NPRP6 - 1283 - 3 - 30, $862,553

Development of Absolute quantification kit for CALR types 1 and 2 mutations for Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) patients, LPI. QIPA1 0908-14039, $ 100,000

Exome Sequencing in Patients from Qatar and other Arab Countries to Improve Diagnosis of White Matter Diseases, PI. NPRP6 - 1463 - 3 – 351, $ 1,049,000

Areas of specialism

  • Genetics and Genomics
  • Epigenetics
  • Precision medicine

Publications

Number of items: 14.

Article

Ismail, Mohamed A., Nasrallah, Gheyath K., Monne, Maria, AlSayab, Ali, Yassin, Mohamed A., Varadharaj, Govindarajulu, Younes, Salma, Sorio, Claudio, Cook, Richard, Modjtahedi, Helmout and Al-Dewik, Nader (2022) Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors. Gene, 813, p. 146101. ISSN (print) 0378-1119

Younes, Salma, Samara, Muthanna, Salama, Noor, Al-jurf, Rana, Nasrallah, Gheyath, Al-Obaidly, Sawsan, Salama, Husam, Olukade, Tawa, Hammuda, Sara, Abdoh, Ghassan, Abdulrouf, Palli Valapila, Farrell, Thomas, AlQubaisi, Mai, Al Rifai, Hilal and Al-Dewik, Nader (2021) Incidence, risk factors, and feto-maternal outcomes of inappropriate birth weight for gestational age among singleton live births in Qatar : a population-based study. PLoS ONE, 16(10), e0258967. ISSN (online) 1932-6203

Younes, Salma, Samara, Muthanna, Al-Jurf, Rana, Nasrallah, Gheyath, Al-Obaidly, Sawsan, Salama, Husam, Olukade, Tawa, Hammuda, Sara, Ismail, Mohamed A., Abdoh, Ghassan, Abdulrouf, Palli Valapila, Farrell, Thomas, AlQubaisi, Mai, Al Rifai, Hilal Al and Al-Dewik, Nader (2021) Incidence, risk factors, and outcomes of preterm and early term births : a population-based register study. International Journal of Environmental Research and Public Health, 18(11), e5865. ISSN (online) 1660-4601

Ismail, Mohamed A., Vezzalini, Marzia, Morsi, Hisham, Abujaber, Ahmad, Al Sayab, Ali, Siveen, Kodappully, Yassin, Mohamed A., Monne, Maria, Samara, Muthanna, Cook, Richard, Sorio, Claudio, Modjtahedi, Helmout and Al-Dewik, Nader I. (2021) Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients. Scientific Reports, 11, p. 8833. ISSN (online) 2045-2322

Ismail, Mohamed A., Samara, Muthanna, Al Sayab, Ali, Alshashani, Mohamed, Yassin, Mohamed A., Varadharaj, Govindaraiulu, Vezzalini, Mariza, Tomasello, Luisa, Monne, Maria, Morsi, Hisham, Qoronfleh, M. Walid, Zayed, Hatem, Cook, Richard, Sorio, Claudio, Modjtahedi, Helmout and Al-Dewik, Nader I. (2020) Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the state of Qatar. Molecular Genetics and Genomic Medicine, 8(10), e1319. ISSN (online) 2324-9269

Ben-Omran, Tawfeg, Al Ghanim, Kaltham, Yavarna, Tarunashree, El Akoum, Maha, Samara, Muthanna, Chandra, Prem and Al-Dewik, Nader (2020) Effects of consanguinity in a cohort of subjects with certain genetic disorders in Qatar. Molecular Genetics & Genomic Medicine, 8(1), e1051. ISSN (online) 2324-9269

Samara, Muthanna, Hammuda, Sara, Vostanis, Panos, El-Khodary, Basel and Al-Dewik, Nader (2020) Children’s prolonged exposure to the toxic stress of war trauma in the Middle East. British Medical Journal (BMJ), 371, m3155. ISSN (print) 1759-2151

Al-Dewik, Nader I, Morsi, Hisham M, Samara, Muthanna M, Ghasoub, Rola S, Gnanam, Cinquea C, Bhaskaran, Subi K, Nashwan, Abdulqadir J, Al-Jurf, Rana M, Ismail, Mohamed A, AlSharshani, Mohammed M, AlSayab, Ali A, Ben-Omran, Tawfeg I, Khatib, Rani B and Yassin, Mohamed A (2016) Is adherence to Imatinib Mesylate treatment among patients with chronic myeloid leukemia associated with better clinical outcomes in Qatar? Clinical Medicine Insights : Oncology, 10, pp. 95-104. ISSN (online) 1179-5549

Al-Dewik, Nader I, Jewell, Andrew P, Yassin, Mohammed A and Morsi, Hisham M (2015) Studying the impact of presence of alpha acid glycoprotein and protein glycoprotein in chronic myeloid leukemia patients treated with imatinib mesylate in the State of Qatar. Biomarkers in Cancer, 7, pp. 63-67. ISSN (online) 1179-299X

Book Section

Younes, Salma N., Al-Jurf, Rana, Hammuda, Sara, Nasrallah, Gheyath K., Al-Jurf, Amal, Ziyada, Ayah, Abdulrouf, Palli Valapila, Qoronfleh, M. Walid, Samara, Muthanna and Al-Dewik, Nader (2022) Attention-deficit hyperactivity disorder : genetic, pharmacogenetic, and metabolomic insights. In: Qoronfleh, M. Walid , Essa, Musthafa Mohamed and Chidambaram, Saravana Babu, (eds.) Proteins associated with neurodevelopmental disorders. Singapore : Springer Singapore. pp. 135-189. (Nutritional Neurosciences) ISSN (print) 2730-6712 ISBN 9789811597800

Younes, Salma N., Al-Jurf, Rana, Hammuda, Sara, Nasrallah, Gheyath K., Zayed, Hatem, Qoronfleh, M. Walid, Ismail, Mohamed A., Farrell, Tom, Al-Rifai, Hilal, Samara, Muthanna and Al-Dewik, Nader (2022) Principal molecular pathways affected in autism spectrum disorder. In: Qoronfleh, M. Walid , Essa, Musthafa Mohamed and Chidambaram, Saravana Babu, (eds.) Proteins associated with neurodevelopmental disorders. Singapore : Springer Singapore. pp. 1-47. (Nutritional Neurosciences) ISSN (print) 2730-6712 ISBN 9789811597800

Al-Dewik, Nader and Alsharshani, Mohammed (2020) New horizons for molecular genetics diagnostic and research in autism spectrum disorder. In: Essa, M. Mohamed and Qoronfleh, M. Walid, (eds.) Personalized food intervention and therapy for autism spectrum disorder management. Cham, Switzerland : Springer Nature. pp. 43-81. (Advances in Neurobiology, (24)) ISSN (print) 2190-5215 ISBN 9783030304010

Shaltout, Eman, Al-Dewik, Nader, Samara, Muthanna, Morsi, Hisham and Khattab, Azhar (2020) Psychological comorbidities in autism spectrum disorders. In: Essa, M. Mohamed and Qoronfleh, M. Walid, (eds.) Personalized food intervention and therapy for autism spectrum disorder management. Cham, Switzerland : Springer. pp. 163-191. (Advances in Neurobiology, (24)) ISSN (print) 2190-5215 ISBN 9783030304010

Thesis

Al-Dewik, Nader (2012) Mechanism(s) of resistance of Chronic Myelocytic Leukaemia (CML) to Glivec in a patient population in the State of Qatar. (PhD thesis), Kingston University, .

This list was generated on Wed Nov 30 07:06:00 2022 GMT.

Business, knowledge transfer and international

Research student supervision

Current Graduate-level (Ph.D.) students

Mohamed Ismail, Noora Younes, Duaa Al-Sadeq, Dalal Alsharshani

Current Graduate level (MSc)

Sara Jemmieh, Shaza Alkhidir, Dima Alasmar

Previous Graduate level (MSc)

Fatma Alzayra, Samar Shurbaji, Foziyeh Naji, Abeer Mahdi, Abeer Qush, Dalal Alsharshani, Munira A. Aden, Zenat M. Kanfosh, Kholoud Aljassim, Mohammed Alsharshani, Mashael Al-Badr.

Previous Undergraduate level (BSc):

Salsabel Elshami and Nada Nasser

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