Dr Bhupinder Sharma

Research project: Imaging Assessment of Haematopoietic and Lymphoid Tumours; Advancing Methodologies and Applications

Abstract

Accurate disease detection is critical for optimal outcomes in haematological-malignancies. However, the appropriate use of imaging tests requires awareness of their strengths and limitations. I address four key themes in my PhD ‘by prior publications'.

Reporting in haematological malignancies has lacked standardisation. Analogous to UK NICE Guidelines in pathology, I formulated a methodology, termed ‘Specialist Integrated Haematological Malignancy Imaging Reporting'.

Breast implant-associated anaplastic large cell lymphoma imaging has varied widely. I developed new patient algorithms, subsequently endorsed by UK Guidelines.

Prompt diagnosis of Richter transformation from chronic lymphocytic leukaemia was needed. I formulated a PET-CT driven pathway to decide i) biopsy requirement ii) select representative biopsy site.

Lastly, MRI, used for central nervous system lymphoma imaging, was unable to differentiate disease activity from benign change. I developed two original applications, contrast clearance analysis, and 18F-choline PET-CT.

My thesis advances global imaging methodologies and applications in haematological-malignancies.

 

  • Research degree: PhD by prior publication/portfolio
  • Title of project: Imaging Assessment of Haematopoietic and Lymphoid Tumours; Advancing Methodologies and Applications
  • Research supervisor: Professor Priscilla Harries
  • Other research supervisor: Dr Marcus Jackson

Biography

I am Consultant Radiologist at The Royal Marsden Hospital, Honorary Faculty The Institute of Cancer Research GB, & Expert Advisor UK NICE Centre for Guidelines Development.

I graduated in Southampton, 1993 with a prize and 1st class Honours intercalated BSc and trained at the Hammersmith, London Chest & Guys Hospitals. I have over 200 publications, with a preponderance of senior authorships, including multiple Nature Reviews Clinical Oncology, JCO, BJHaem & Radiographics papers. I have extensive ASH, ASCO & RSNA, Lugano, ECR and other international conference publications. I have formulated seven national guidelines and written seven book chapters. I lead four International clinical/research meetings at the RMH/ICR. I am imaging lead for the RMH lymphoma & lung MDTMs, PET lead for the breast MDTM. I have extensive national and international research collaborations, including with MSKCC, The Mayo Clinic, MD Anderson & Dana-Farber, USA. I supervise multiple RMH/ICR PhD and MD students.

Areas of research interest

  • Imaging in Haematological Malignancies

Qualifications

  • Bachelor of Science (hons), University of Southampton
  • Bachelor of Medicine, University of Southampton
  • FRCR
  • Clinical Radiology CCST

Funding or awards received

  • £1000 study expenses from The Royal Marsden NHS Foundation Trust

Publications

Approximately over 200 publications including conference publications, National and International guidelines and book chapters.