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Accurate disease detection is critical for optimal outcomes in haematological-malignancies. However, the appropriate use of imaging tests requires awareness of their strengths and limitations. I address four key themes in my PhD ‘by prior publications'.
Reporting in haematological malignancies has lacked standardisation. Analogous to UK NICE Guidelines in pathology, I formulated a methodology, termed ‘Specialist Integrated Haematological Malignancy Imaging Reporting'.
Breast implant-associated anaplastic large cell lymphoma imaging has varied widely. I developed new patient algorithms, subsequently endorsed by UK Guidelines.
Prompt diagnosis of Richter transformation from chronic lymphocytic leukaemia was needed. I formulated a PET-CT driven pathway to decide i) biopsy requirement ii) select representative biopsy site.
Lastly, MRI, used for central nervous system lymphoma imaging, was unable to differentiate disease activity from benign change. I developed two original applications, contrast clearance analysis, and 18F-choline PET-CT.
My thesis advances global imaging methodologies and applications in haematological-malignancies.
I am Consultant Radiologist at The Royal Marsden Hospital, Honorary Faculty The Institute of Cancer Research GB, & Expert Advisor UK NICE Centre for Guidelines Development.
I graduated in Southampton, 1993 with a prize and 1st class Honours intercalated BSc and trained at the Hammersmith, London Chest & Guys Hospitals. I have over 200 publications, with a preponderance of senior authorships, including multiple Nature Reviews Clinical Oncology, JCO, BJHaem & Radiographics papers. I have extensive ASH, ASCO & RSNA, Lugano, ECR and other international conference publications. I have formulated seven national guidelines and written seven book chapters. I lead four International clinical/research meetings at the RMH/ICR. I am imaging lead for the RMH lymphoma & lung MDTMs, PET lead for the breast MDTM. I have extensive national and international research collaborations, including with MSKCC, The Mayo Clinic, MD Anderson & Dana-Farber, USA. I supervise multiple RMH/ICR PhD and MD students.
Approximately over 200 publications including conference publications, National and International guidelines and book chapters.