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Cardiotoxicity-induced by anti-cancer drugs is a life-threatening adverse event. The number of treatment modalities enormously increased as a result of enhancements in oncology research. This also caused an increase in the number of cardiotoxic anti-cancer agents. Published literature indicates that cardiotoxicity associated with anti-cancer drugs was observed in 1-30% of the patients. Introduction of novel therapeutics such as tyrosine-kinase inhibitors and immune check-point inhibitors were found to be associated with cardiotoxicity but have not been extensively investigated. We carry out a research project in collaboration with The Royal Marsden NHS Foundation Trust to investigate the causes of cardiotoxicity in non-small cell lung cancer populations in a real-world setting (e.g. gender, age, smoking status, etc.). Another aim of this study is to understand the true incidence of cardiotoxicity in non-small cell lung cancer patients who receive novel therapeutics. We also run several other research projects to investigate the cardio-oncology practice, worldwide.
I am a Cypriot pharmacist graduated from Eastern Mediterranean University. My thesis was on lithium-induced toxicities in North Cyprus. After my graduation, I started to do a Ph.D. at Kingston University, London in 2018. From the beginning of my undergraduate studies until now, I worked in several fields including hospital management, community pharmacy and currently working as a teaching assistant at Kingston University for the modules called Professional Pharmacy skills and Interprofessional learning. My current Ph.D. project is cardio-oncology which is a growing topic related to the management of cardiac side effects of anti-cancer drugs. Drug-related toxicities describe my main field of interest. Nowadays, I am building my career in the science of real-world evidence. I believe that clinical trials in oncology are not enough to reveal the main effects and safety of cancer drugs. Because of that, real-world studies are and should be an indispensable part of oncology trials.
Kobat, Hasan, Elkonaissi, Islam, Foreman, Emma, O’Brien, Mary, Dorak, Mehmet Tevfik and Nabhani-Gebara, Shereen (2022) Investigating the efficacy of osimertinib and crizotinib in phase 3 clinical trials on anti-cancer treatment-induced cardiotoxicity : are real-world studies the way forward? Journal of Oncology Pharmacy Practice, ISSN (print) 1078-1552 (Epub Ahead of Print)
Kobat, Hasan, Elkonaissi, Islam, Dorak, Mehmet Tevfik and Nabhani-Gebara, Shereen (2021) Management of COVID-19 in cancer patients receiving cardiotoxic anti-cancer therapy. Future recommendations for cardio-oncology. Oncology Reviews, 15(1), ISSN (print) 1970-5557
Kobat, Hasan (2021) International investigation of cardio-oncology practice. In: BOPA 24th Annual Symposium; 08 - 10 Oct 2021, Held online. (Unpublished)
Kobat, H., Elkonaissi, I., Foreman, E., O'Brien, M. and Nabhani-Gebara, S. (2021) Osimertinib and crizotinib cardiotoxicity : are real-world studies the way forward? In: ESMO Congress 2021; 16 - 21 Sep 2021, Paris, France (held online). (Unpublished)