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The subcutaneous insulin administration is considered the most effective treatment for the diabetes mellitus, a chronic condition affecting the large number of people across the world at an increasing rate. Due to several drawbacks associated with the subcutaneous mode of insulin administration and high frequency of the insulin dose required to normalise the hyperglycaemic levels, there is a need to develop a novel insulin delivery system capable of improving patient compliance with minimum side effects. This research study is aimed at designing a smart insulin delivery system in the form of a formulation based on nanotechnology. The insulin-loaded nanoparticles using naturally existing glucose sensitive polymers such as chitosan or polyacrylic acid and a glucose-sensitive cross-linker will be prepared and characterised for their particle size, morphology and surface charge. The work will also evaluate the release kinetics of insulin from the formulation under different glucose concentrations. In-vitro evaluation and toxicology studies will be used to understand the pharmacokinetics of the new delivery system.
I am overseas pharmacist and have successfully completed my MSc Pharmaceutical Sciences in Kingston University, London and have started my PhD in June 2018 with Kingston University, London.
My professional experience includes pharmaceutical manufacturing and clinical and community pharmacy.