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Miss Ayse Merve Orme

Research project: The role of THC and synthetic cannabinoid's as mediator's of actin cytoskeletal rearrangement and fibrosis in hepatic stellate cell

Abstract

In the field of forensic toxicology, cannabinoids are the most commonly used drug in the UK. Despite the risks and widespread use of cannabinoids it's long term effects on organs such as the heart and liver is still unclear. Common drugs of abuse such as alcohol (ethanol) have been extensively researched and shown to induce morphological changes in the architecture of hepatic and cardiac tissue leading to fibrosis and organ failure. By contrast research on the effects of cannabinoids in these cells has shown that this drug may contribute to the pathogenesis of fibrosis but as yet there has been no definitive cell signalling mechanism implicated.

  • Research degree: PhD
  • Title of project: The role of THC and synthetic cannabinoid's as mediator's of actin cytoskeletal rearrangement and fibrosis in hepatic stellate cell
  • Research supervisor: Dr Elena Polycarpou
  • Other research supervisor: Dr Scott Lawton

Biography

I am currently studying a Doctor of Philosophy degree in Forensic Toxicology at Kingston University. I am seeking to commit myself as a researcher in the field of biological research and academia. During my bachelor's and master's degree, I have acquired key laboratory skills through the participation of many practical sessions and through an independent library-based study I have gained critical analysis skills to which I have been able to implement during my PhD and contribute as an author of an accepted review article. 

Areas of research interest

  • Molecular biology
  • Cytoskeleton
  • Fibrosis
  • Drugs of abuse
  • Cell biology

Qualifications

  • BSc in Biology; Abant Izzet Baysal University
  • MSc in Forensic Medical Science; Queen Mary University of London

Funding or awards received

  • Funded Erasmus study in Poland
  • lzzet Baysal scholarship for being honor student during BSc
  • Turkish Educational Embassy scholarship during MSc
  • Turkish Educational Embassy scholarship for PhD

Publications

Verma, A, Bennet, J, Orme, A.M, Polycarpou, E and Rooney, BV (2019) Cocaine addicted to a Fibrotic high. Cytoskeleton. DOI:doi.org/10.1002/cm.21510

Accepted: 19 December 2018

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