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Anterior uveitis is one of the common forms of inflammation in the eye and can be the cause of visual impairment for 1 in 10 people. At present, the common treatment for anterior uveitis is by the use of corticosteroids which is present in eye drop formulations. However, the use of eye drops requires frequent dosage hence reducing patient compliance. Bioavailability for ocular treatment is reduced due to the ocular barriers (<5%).
Polymeric nanoparticles propose good drug release systems because of their biocompatibility and biodegradable properties. PCL has an easily manipulated structure, therefore could be a great polymer to use for the formulation of nanoparticles. The aim of this research study is to formulate and characterize polycaprolactone nanoparticles loaded with dexamethasone. The drug will be quantified using HPLC and a suitable formulation will be chosen from which in-vitro drug release testing and biological evaluation will be conducted.
I am a graduate in Pharmaceutical sciences and have learnt a lot of skills throughout my undergraduate degree such as good laboratory skills and the importance of them in real world applications. This enabled me to pursue a PhD as I wanted to take the skills I had learnt and apply them to my own research and project and discover new things and gain in-depth knowledge in my specific area.
Alongside my time as a Kingston university student, I take pride in teaching and helping other students to the best of my ability therefore, I work as a tutor for A-level Chemistry and Biology students, both privately and as part of academic staff in an academy.