Search our site
Search our site

Dr Adam Le Gresley

Associate Professor

About

I obtained my PhD from the University of Surrey, working under Professor Nikolai Kuhnert on the synthesis of Calix[4]arene derivatives for dynamic combinatorial libraries. I undertook my postdoctoral work as an NIH Research Fellow at Drexel College of Medicine in the USA, working on the synthesis and evaluation of "caged" compounds for probing biological pathways.

Since joining Kingston University in 2009, I have established a research group in organic and analytical chemistry, funded by industrial sponsors such as GlaxoSmithKline and LGC Ltd, working on the design and synthesis of fluorogenic compounds for problem pathogen detection and method development for NMR metabolomics/2D qNMR for complex mixture analysis and metrology. I have collaborations with institutions in Germany, Australia and the USA. I have 20 publications in peer-reviewed journals and 2 patents.

Contact Details:

Address: PRMB2017, Kingston University, London, KT1 2EE

Tel: +44 (0)208 4177432

Email: a.legresley@kingston.ac.uk

Areas of specialism

  • Synthetic Chemistry
  • Medicinal Chemistry
  • NMR
  • Metabolomics

Qualifications

  • 2009-2010: Postgraduate Certificate in Higher Education - Kingston University.
  • 2000-2004: PhD in Organic and Supramolecular Chemistry - University of Surrey.
  • 1996-2000: BSc(Hons) Chemistry with a Industrial Placement - University of Surrey.

Professional membership

  • Member of the Royal Society of Chemistry
  • Fellow of the Higher Education Academy

Research

I am currrently leading a number of research projects in Skin Health, Metrology and G-quadruplex ligand development for cancer treatment,

  • Skin Health project- funded by GSK - PhD Student - Cameron Robertson
  • 2D NMR metrology - funded by LGC - PhD Student - Fahmina Fardus-Reid
  • Synthesis of Anthracene-bis(acrylamido) derivatives - PhD Student - Tomris Coban

I also co-supervise PhD students on the following projects,

  • New fluorogenic probe development for <i>S aureus</i> - PhD Student - Luke Bywaters
  • New probe development for Foot and Mouth disease - PhD Student - Samerah Malik

I am also involved in a number of cross-faculty research projects aided by UG/PG project students;

  • Anti-viral small molecule identification,
  • Novel antibiotic discovery from soil,
  • Rab7 antagonists for the treatment of diabetes
  • Process modelling for biofuel development.
  • Post-process Chitin and Chitosan analysis (Zystur Ltd)

Research student supervision

Publications

Number of items: 22.

Article

Bywaters, Luke, Mulcahy-Ryan, Lauren, Fielder, Mark, Sinclair, Alex and Le Gresley, Adam (2017) Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of 'Staphylococcus aureus'. Molecular and Cellular Probes, ISSN (print) 0890-8508 (Epub Ahead of Print)

Vienescu, D.N., Wang, J., Le-Gresley, A. and Nixon, J.D. (2017) A life cycle assessment of options for producing synthetic fuel via pyrolysis. Bioresource Technology, ISSN (print) 0960-8524 (Epub Ahead of Print)

Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E (2016) Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents. Organic & Biomolecular Chemistry, 14, pp. 3069-3079. ISSN (print) 1477-0520

Fardus-Reid, Fahmina, Warren, John and Le Gresley, Adam (2016) Validating heteronuclear 2D quantitative NMR. Analytical Methods, 8(9), pp. 2013-2019. ISSN (print) 1759-9660

Le Gresley, Adam, Fardus, Fahmina and Warren, John (2015) Bias and uncertainty in non-ideal qNMR Analysis. Critical reviews in analytical chemistry / CRC, 45(4), pp. 300-10. ISSN (print) 1547-6510

Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert (2015) The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries. Analytical Methods, 7(6), p. 2323.

Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam (2013) Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments. Organic & Biomolecular Chemistry, 11(20), pp. 3307-3313. ISSN (print) 1477-0520

Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D (2012) The application of high resolution diffusion NMR to the analysis of manuka honey. Food Chemistry, 135(4), pp. 2879-86. ISSN (print) 0308-8146

Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039

Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza, Lafon, Shehri and Sinclair, Alex (2011) Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2(6), pp. 466-470. ISSN (print) 2040-2503

Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri (2010) Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands. Synthetic Communications, 41(16), pp. 2483-2492. ISSN (print) 0039-7911

Le-Gresley, A and Kuhnert, N (2010) The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries. Journal of Chemical Research, 2, pp. 61-67. ISSN (print) 1747-5198

Kuhnert, Nikolai and Le Gresley, Adam (2008) Synthesis of upper rim calix[4]arene carcerands. Tetrahedron Letters, 49(7), pp. 1274-1276. ISSN (print) 0040-4039

Kuhnert, Nikolai, Le Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana (2007) Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer. Journal of Labelled Compounds and Radiopharmaceuticals, 50(13), pp. 1215-1223. ISSN (print) 0362-4803

Kuhnert, Nikolai and Le Gresley, Adam (2005) Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes. Organic & Biomolecular Chemistry, 3(11), pp. 2175-2182. ISSN (print) 1477-0520

Kuhnert, Nikolai and Le-Gresley, Adam (2005) The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries. Tetrahedron Letters, 46(12), pp. 2059-2062. ISSN (print) 0040-4039

Kuhnert, Nikolai and Le-Gresley, Adam (2003) The synthesis of tetra-acrylamido-calix[4]arene capsules. Chemical Communications, 19, pp. 2426-2427. ISSN (print) 1359-7345

Kuhnert, Nikolai and Le Gresley, Adam (2001) On the scope and limitations of the Heck reaction of upper rim tetraiodocalix[4]arenes. Perkin Transactions 1, 24, pp. 3393-3398. ISSN (print) 1472-7781

Conference or Workshop Item

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)

Le Gresley, Adam, Gollapalli, Uma [Contributor] and Ghosh, Uttam [Contributor] (2009) The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR. In: National Cancer Research Institute Cancer Conference; 04 -07 Oct 2009, Birmingham, U.K.. (Unpublished)

Le Gresley, Adam and Kuhnert, Nikolai [Contributor] (2009) The synthesis of novel calix[4]arene tetra-acrylates and their potential use as macrocyclic platforms in the development of static and dynamic combinatorial libraries using reversible imine formation. In: IUPAC Conference; , Glasgow, UK. (Unpublished)

Patent

Sinclair, Alex [Inventor], Fielder, Mark [Inventor] and Le Gresley, Adam [Inventor] (2013) Kingston University Higher Education Corporation Rhodamine based fluorescent probe for coagulase activity and detection of coagulase producing bacterial strains. WO 2014013272 A1.

This list was generated on Sun Nov 19 04:52:26 2017 GMT.
>

Looking for academic staff in the Faculty of Health, Social Care and Education? Visit the Faculty website

Site menu