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Dr Scott Lawton

Senior lecturer

About

I did my first degree in Zoology at the University of Aberdeen (1999-2003) where I became interested in evolutionary biology and parasitology and infectious diseases. After taking a year out I then undertook an MSc in Parasitology and Entomology at the Liverpool School of Tropical Medicine (2004 - 2005) where I became increasingly interested in the use of molecular genetics in the identification and monitoring of disease vectors and vector borne diseases and later went on to be involved in a project to produce the first phylogenetic framework for Tsetse flies (Glossina sp.) the vectors of African Sleeping Sickness. Following on from my time at Liverpool I then undertook a PhD at the Natural History Museum (2005 -2009) focused on the genomics and molecular evolution of Schistosoma blood flukes of medical and veterinary importance and then in 2009 joined Kingston University, London as a lecturer in Biological Sciences.

Areas of specialism

  • Medical and Veterinary Parasitology
  • Zoonotic and Vector Borne Diseases
  • Molecular Evolution and Ecology
  • Molecular Epidemiology
  • Evolutionary Genomics

Qualifications

  • PhD: Molecular Genomics and Evolution of Schistosoma blood flukes (Natural History Museum & University of Wales, Aberystwyth)
  • MSc: Biology and Control of Parasites and Disease Vectors (Liverpool School of Tropical Medicine)
  • BSc (Hons) Zoology (University of Aberdeen)
  • Postgraduate Certificate in Learning and Teaching in Higher Education (Kingston University, London)

Professional membership

Fellow of the Royal Society of Tropical Medicine and Hygiene 

Member of the British Society for Parasitology

Fellow of the Higher Education Academy

Research

My research focuses on the development and application of molecular and genomic tools to provide insights into the evolutionary and ecological processes acting on pathogens, parasites and invasive species in order to inform epidemiological studies, surveillance and control. I have a "one health" ethos to my research and the emphasis is primarily on zoonotic parasites affecting the health of wildlife, domestic animals and people in the tropics as well as invasions and emergence of parasites, disease vectors and economically important invertebrates throughout Europe. The main goal is to disentangle the underlying evolutionary events acting on such populations ranging from the detection of speciation events through to adaptive responses to host specific pressures such as antigenic variation, host compatibility, drug resistance and environmental tolerance, and the development of molecular tools to identify and monitor the spread of such organisms. My work is not only applied to organisms of direct importance to human and animal health but also those that could impact upon food security and biodiversity conservation. The work in my lab depends heavily on molecular techniques ranging from standard PCR for species identification to next generation sequencing and major downstream bioinformatics to identify genes that regulate parasitism and act as speciation barriers coupled with field work not only for collection but for monitoring infections and invasive organisms. Currently my team and I have five overlapping research areas

 

1.     The development and application of phylogenetically sound markers and the application of phylogeographical methodologies for the monitoring and surveillance of infectious diseases and invasive species

2.     Development and application of molecular barcoding techniques to identify emerging pathogens, disease vectors and invasive invertebrates of economic importance

3.     Using large molecular sequence data sets to model population evolutionary histories in order to infer historical ecological events as well as understanding transmission and spread of infection by estimate population divergence times, modelling demographic history, gene flow between localities (including hosts and environments) as well as adaptation and speciation events

4.     The use of genomic tools including next generation sequencing technologies, postgenomic data mining and protein functional modelling approaches to identify genes and molecular markers which can be used to monitor the spread of drug resistance, antigenic variation and virulence in pathogens

5.     Development of user friendly simple bioinformatic methodologies to understand parasite host interactions from the cellular to population level and for surveillance of invasive invertebrate species

Research student supervision

Publications

Jump to: Article
Number of items: 13.

Article

Santoro, M., Di Nocera, F., Iaccarino, D., Lawton, S. P., Cerrone, A., degli Uberti, B., D’Amore, M., Affuso, A., Hochscheid, S., Maffucci, F. and Galiero, G. (2017) Pathology and molecular analysis of ' Hapalotrema mistroides ' (Digenea: Spirorchiidae) infecting a Mediterranean loggerhead turtle ' Caretta caretta '. Diseases of Aquatic Organisms (DAO), 124(2), pp. 101-108. ISSN (print) 0177-5103

Lawton, Scott P., Bowen, Lauren I., Emery, Aidan M. and Majoros, Gabor (2017) Signatures of mito-nuclear discordance in 'Schistosoma turkestanicum' indicate a complex evolutionary history of emergence in Europe. Parasitology, ISSN (print) 0031-1820 (Epub Ahead of Print)

Adema, Coen M, Hillier, LaDeana W, Jones, Catherine S, Loker, Eric S, Knight, Matty, Minx, Patrick, Oliveira, Guilherme, Raghavan, Nithya, Shedlock, Andrew, do Amaral, Laurence Rodrigues, Arican-Goktas, Halime D, Assis, Juliana G, Baba, Elio Hideo, Baron, Olga L, Bayne, Christopher J, Bickham-Wright, Utibe, Biggar, Kyle K, Blouin, Michael, Bonning, Bryony C, Botka, Chris, Bridger, Joanna M, Buckley, Katherine M, Buddenborg, Sarah K, Lima Caldeira, Roberta, Carleton, Julia, Carvalho, Omar S, Castillo, Maria G, Chalmers, Iain W, Christensens, Mikkel, Clifton, Sandra, Cosseau, Celine, Coustau, Christine, Cripps, Richard M, Cuesta-Astroz, Yesid, Cummins, Scott F, di Stephano, Leon, Dinguirard, Nathalie, Duval, David, Emrich, Scott, Feschotte, Cédric, Feyereisen, Rene, FitzGerald, Peter, Fronick, Catrina, Fulton, Lucinda, Galinier, Richard, Gava, Sandra G, Geusz, Michael, Geyer, Kathrin K, Giraldo-Calderón, Gloria I, de Souza Gomes, Matheus, Gordy, Michelle A, Gourbal, Benjamin, Grunau, Christoph, Hanington, Patrick C, Hoffmann, Karl F, Hughes, Daniel, Humphries, Judith, Jackson, Daniel J, Jannotti-Passos, Liana K, de Jesus Jeremias, Wander, Jobling, Susan, Kamel, Bishoy, Kapusta, Aurélie, Kaur, Satwant, Koene, Joris M, Kohn, Andrea B, Lawson, Dan, Lawton, Scott P, Liang, Di, Limpanont, Yanin, Liu, Sijun, Lockyer, Anne E, Lovato, TyAnna L, Ludolf, Fernanda, Magrini, Vince, McManus, Donald P, Medina, Monica, Misra, Milind, Mitta, Guillaume, Mkoji, Gerald M, Montague, Michael J, Montelongo, Cesar, Moroz, Leonid L, Munoz-Torres, Monica C, Niazi, Umar, Noble, Leslie R, Oliveira, Francislon S, Pais, Fabiano S, Papenfuss, Anthony T, Peace, Rob, Pena, Janeth J, Pila, Emmanuel A, Quelais, Titouan, Raney, Brian J, Rast, Jonathan P, Rollinson, David, Rosse, Izinara C, Rotgans, Bronwyn, Routledge, Edwin J, Ryan, Kathryn M, Scholte, Larissa L S, Storey, Kenneth B, Swain, Martin, Tennessen, Jacob A, Tomlinson, Chad, Trujillo, Damian L, Volpi, Emanuela V, Walker, Anthony J, Wang, Tianfang, Wannaporn, Ittiprasert, Warren, Wesley C, Wu, Xiao-Jun, Yoshino, Timothy P, Yusuf, Mohammed, Zhang, Si-Ming, Zhao, Min and Wilson, Richard K (2017) Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, 8(15451), ISSN (online) 2041-1723

Hirst, Natasha L., Lawton, Scott P. and Walker, Anthony J. (2016) Protein kinase A signalling in ' Schistosoma mansoni ' cercariae and schistosomules. International Journal for Parasitology, 46(7), pp. 425-437. ISSN (print) 0020-7519

Santoro, Mario, Cipriani, Paolo, Pankov, Plamen and Lawton, Scott (2015) Aporocotyle michaudi n. sp. (Digenea: Aporocotylidae) from the emerald rock cod, Trematomus bernacchii (Teleostei: Perciformes) in Antarctica. Parasitology international, 64(5), pp. 324-329. ISSN (print) 1873-0329

Lawton, Scott P., Lim, Rivka M., Dukes, Juliet P., Kett, Stephen M., Cook, Richard T., Walker, Anthony J. and Kirk, Ruth S. (2015) Unravelling the riddle of ' Radix ' : DNA barcoding for species identification of freshwater snail intermediate hosts of zoonotic digeneans and estimating their inter-population evolutionary relationships. Infection, Genetics and Evolution, 35, pp. 63-74. ISSN (print) 1567-1348

Lawton, Scott P., Lim, Rivka M., Dukes, Juliet P., Cook, Richard T., Walker, Anthony J. and Kirk, Ruth S. (2014) Identification of a major causative agent of human cercarial dermatitis, Trichobilharzia franki (Muller and Kimmig 1994), in southern England and its evolutionary relationships with other European populations. Parasites & Vectors, 7, p. 277. ISSN (online) 1756-3305

Hayes, Polly M., Lawton, Scott P., Smit, Nico J., Gibson, Wendy C. and Davies, Angela J. (2014) Morphological and molecular characterization of a marine fish trypanosome from South Africa, including its development in a leech vector. Parasites & Vectors, 7(50), ISSN (print) 1756-3305

Cook, Courtney A, Lawton, Scott P, Davies, Angela J and Smit, Nico J (2014) Reassignment of the land tortoise haemogregarine Haemogregarina fitzsimonsi Dias 1953 (Adeleorina: Haemogregarinidae) to the genus Hepatozoon Miller 1908 (Adeleorina: Hepatozoidae) based on parasite morphology, life cycle and phylogenetic analysis of 18S rDNA sequence fragments. Parasitology, 141(12), pp. 1611-1620. ISSN (print) 0031-1820

Sealey, Katie L., Kirk, Ruth S., Walker, Anthony J., Rollinson, David and Lawton, Scott (2013) Adaptive radiation within the vaccine target tetraspanin-23 across nine Schistosoma species from Africa. International Journal for Parasitology, 43(1), pp. 95-103. ISSN (print) 0020-7519

Lawton, Scott P. and Majoros, Gábor (2013) A foreign invader or a reclusive native? DNA bar coding reveals a distinct European lineage of the zoonotic parasite 'Schistosoma turkestanica' (syn. 'Orientobilharzia turkestanicum' (Dutt and Srivastava, 1955)). Infection, Genetics and Evolution, 14, pp. 186-193. ISSN (print) 1567-1348

Lawton, Scott P., Hirai, Hirohisa, Ironside, Joe E., Johnston, David A. and Rollinson, David (2011) Genomes and geography: genomic insights into the evolution and phylogeography of the genus 'Schistosoma'. Parasites & Vectors, 4(1), ISSN (online) 1756-3305

Dyer, N.A, Lawton, S.P., Ravel, S., Choi, K.S, Lehane, M.J, Robinson, A.S, Okedi, L.M, Hall, M.J, Solano, P. and Donnelly, M.J (2008) Molecular phylogenetics of tsetse flies (Diptera: Glossinidae) based on mitochondrial (COI, 16S, ND2) and nuclear ribosomal DNA sequences, with an emphasis on the palpalis group. Molecular Phylogenetics and Evolution, 49, pp. 227-239. ISSN (print) 1055-7903

This list was generated on Wed Dec 13 04:43:59 2017 GMT.
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