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Mr Miles Benardout

Research project: Vesicles for the Delivery of Insulin: Polymerization Induced SelfAssembly to Access Smart Sugar-Responsive Polymersomes

Abstract

Diabetes is a lifelong condition where suffers have inadequate control of blood glucose concentrations. Treatment of diabetes involves a combination of diet control, exercise, glucose monitoring, medication, and insulin injection. These current regimes are far from perfect and rely heavily on informed patient compliance. In this research, we will prepare sugar-sensitive vesicles for the controlled delivery of insulin. This new technology removes the requirement for patient glucose monitoring, since the vesicle would collapse in vivo to release the insulin at a certain blood glucose concentration. This project will achieve the first synthesis of sugar-sensing polymeric vesicles (so called polymersomes) using Polymerization Induced Self-Assembly (PISA), where simultaneous insulin encapsulation occurs. The objective is to overcome the following challenges: sugar sensing at physiological pH using boronic acid scaffolds and PISA at near to physiological temperature in order to circumvent the denaturing of the insulin protein.

Biography

I am an organic chemist, recently graduated from undergraduate studies in chemistry (BSc), starting my career in research with a PhD. In addition to graduating with a first class degree, I was grateful to be awarded by the RSC for best overall performance on the BSc (Hons) Chemistry degree.

Areas of research interest

  • Organic Chemistry
  • Medicinal Chemistry
  • Synthetic Chemistry
  • Biosensors
  • Medical Technology

Qualifications

  • BSc (hons) Chemistry, Kingston University

Funding or awards received

  • RSC, best overall performance on the BSc (Hons) Chemistry degree, 2019
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