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I am highly experienced in medicinal chemistry and have worked on a diverse set of biological targets over many disease areas in several organisations (Xenova, Argenta Discovery and Summit plc). I have an extensive track record in project and team management, intellectual property, drug discovery in many therapeutic areas and helped lead the chemistry effort directed towards the identification of SMTC1100 (Summit's Duchenne Muscular Dystrophy drug, currently undergoing clinical evaluation).
I have also conducted research at the Alzheimer's Research UK Oxford Drug Discovery Institute and taught at Oxford University (organic chemistry, pharmaceutical chemistry and biomedical sciences). I was a fellow of St Hilda's College, Oxford, between 2015 and 2018. I joined Kingston University London in September 2018, as a lecturer, and became a senior lecturer in 2020.
Senior Lecturer in Organic and Pharmaceutical Chemistry
Organic and medicinal chemistry.
Chemical and biosensors for medical and environmental applications.
Green, Jonathan, Tinson, Ryan A.J., Betts, Jacob H.J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen P., Searcey, Mark and Troeberg, Linda (2023) Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue. Bioorganic & Medicinal Chemistry, 92, p. 117424. ISSN (print) 0968-0896
Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve and Wren, Stephen Paul (2023) Synthesis of squaric acid monoamides as building blocks for drug discovery. SynOpen, ISSN (online) 2509-9396 (In Press)
Mohamed, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James (2022) Development of magnetic molecularly imprinted polymers for the extraction of salivary pepsin prior to analysis by a novel HPLC-SEC method. Polymer, 261, p. 125417. ISSN (print) 0032-3861
Araar, Islam M and Wren, Stephen P (2022) A computational chemistry-driven hypothesis on the mode of action of hipposudoric acid and related analogs. Future Medicinal Chemistry, ISSN (print) 1756-8919 (Epub Ahead of Print)
Benardout, Miles, Le Gresley, Adam, ElShaer, Amr and Wren, Stephen P. (2022) Fructose malabsorption : causes, diagnosis and treatment. British Journal of Nutrition, 127(4), pp. 481-489. ISSN (print) 0007-1145
Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James (2021) Review on molecularly imprinted polymers with a focus on their application to the analysis of protein biomarkers. TrAC Trends in Analytical Chemistry, 144, p. 116431. ISSN (print) 0165-9936
Paulsson-Habegger, Lukas, Snabaitis, Andrew K. and Wren, Stephen P. (2021) Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection. Bioorganic & Medicinal Chemistry, 48, p. 116389. ISSN (print) 0968-0896
Long, Nathan, Le Gresley, Adam and Wren, Stephen (2021) Thiazolidinediones : an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus. ChemMedChem, 16(11), pp. 1717-1736. ISSN (print) 1860-7179
Vink, Guillaume, Nebel, Jean-Christophe and Wren, Stephen P (2021) In silico design of bioisosteric modifications of drugs for the treatment of diabetes. Future Medicinal Chemistry, 13(8), pp. 691-700. ISSN (print) 1756-8919
Scanlon, James J. and Wren, Stephen (2020) Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres. Future Medicinal Chemistry, 12(20), pp. 1855-1864. ISSN (print) 1756-8919
Ritchie, James, Sykes, Andy, Weber, Peter and Wren, Stephen P. (2019) Immuno-oncology : the next generation of breakthrough therapies. Highlights from The Society for Medicines Research Symposium. Oxford, UK - June 21, 2019. Drugs of the Future, 44(7), pp. 599-604. ISSN (print) 0377-8282
Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D., Bambridge, Gabriel, Wren, Stephen P., Nagase, Hideaki and Troeberg, Linda (2017) Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3. Molecular Pharmacology, 92(4), pp. 459-468. ISSN (print) 0026-895X
Wren, Stephen P., Piletsky, Sergey A., Karim, Kal, Gascoine, Paul, Lacey, Richard, Sun, Tong and Grattan, Kenneth T. V. (2015) Computational design and fabrication of optical fibre fluorescent chemical probes for the detection of cocaine. Journal of Lightwave Technology, 33(12), pp. 2572-2579. ISSN (print) 0733-8724
Zangeneh Kamali, Khosro, Pandikumar, Alagarsamy, Sivaraman, Gandhi, Lim, Hong Ngee, Wren, Stephen Paul, Sun, Tong and Huang, Nay Ming (2015) Silver@graphene oxide nanocomposite-based optical sensor platform for biomolecules. RSC Advances, 5(23), pp. 17809-17816. ISSN (online) 2046-2069
Wren, Stephen P., Nguyen, T. Hien, Gascoine, Paul, Lacey, Richard, Sun, Tong and Grattan, Kenneth T.V. (2014) Preparation of novel optical fibre-based cocaine sensors using a molecular imprinted polymer approach. Sensors and Actuators B: Chemical, 193, pp. 35-41. ISSN (print) 0925-4005
Wren, Stephen P. (2022) Tricyclic systems : central carbocyclic ring with fused five- and six-membered rings. In: Aldabbagh, Fawaz, (ed.) Comprehensive Heterocyclic Chemistry IV. Amsterdam : Elsevier. pp. 1003-1019. 10 ISBN 9780128186565