Professor Adam Le Gresley

Prokaryotic metabolic response to water-soluble polymers enhances oxygen drawdown in freshwater systems: a polyethylene glycol case study

Sainju, Drishna, Bercovici, Sarah, Lucas, Robert, Gresley, Adam Le, A․ Horton, Alice and Evans, Claire, 2026, Next Research (3), Published

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Assessing the effects of thermo-oxidation and naturally-occurring trace metal ions on the peroxidative susceptibilities of unrefined and refined sunflower oils: An 1H NMR-coupled chemometrics study

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin, De Mars, Simon and Naughton, Declan P., 2025, Food Research International (221), Published

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Modelling of cetylpyridinium chloride availability in complex mixtures for the prediction of anti-microbial activity using diffusion ordered spectroscopy, saturation transfer difference and 1D NMR

Robertson, Cameron, Batabyal, Sayoni, Whitworth, Darren, Coban, Tomris, Smith, Angharad, Montesanto, Alessandra, Lucas, Robert and Le Gresley, Adam, 2024, Pharmaceuticals (17), 12, Published

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Effectiveness of different antioxidants in suppressing the evolution of thermally induced peroxidation products in hemp seed oil

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Patrick Naughton, Declan, 2024, Food Research International (188), Published

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Using nuclear magnetic resonance to troubleshoot a stability issue in a real-world formulation chassis—application to consumer oral healthcare

Coban, Tomris, Sykes, Hannah, Kulkarni, Shreedhar, Lucas, Robert A., Robertson, Cameron and Le Gresley, Adam, 2024, Pharmaceutics (16), 3, Published

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Modified PSYCHE NMR - the possibility for the direct semi-quantitation of components in mixtures

Durrant, Arija, Peron, Jean Marie R., Langat, Moses K., Robertson, Cameron and Le Gresley, Adam, 2024, Talanta (268), 1, Published

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Suppressing thermo-induced peroxidation products in peroxidatively-susceptible frying oils by the employment of culinary oil blend formulations

Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin and Naughton, Declan Patrick, 2024, Journal of Food Composition and Analysis (125), Published

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Synthesis and evaluation of druglike parameters via 'in silico' techniques for a series of heterocyclic monosquarate-amide derivatives as potential carboxylic acid bioisosteres

Long, N., Le Gresley, A., Wozniak, A., Brough, S. and Wren, S. P., 2024, Bioorganic and Medicinal Chemistry (98), Published

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Evaluation of nuclear magnetic resonance spectroscopy for characterisation and quantitation of water-soluble polymers in river water

Sainju, Drishna, Lucas, Robert and Le Gresley, Adam, 2023, Water Research (245), Published

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Synthesis of squaric acid monoamides as building blocks for drug discovery

Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve and Wren, Stephen Paul, 2023, SynOpen, Accepted/In press

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High-resolution 1H NMR analysis of continuous and discontinuous thermo-oxidative susceptibility of culinary oils during frying at 180Ôäâ

Ampem, Gilbert, Gresley, Adam Le, Grootveld, Martin and Naughton, Declan P., 2023, Journal of Food and Drug Analysis (31), 1 pp 95-115, Published

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Chemical synthesis of a library of natural product-like derivatives based on pinnaic acid and initial evaluation of their anti-cancer activity

Fudger, Alex, Cakir, Okan M., Khan, Yousaf, Sinclair, Alex and Le Gresley, Adam, 2022, Organic and Biomolecular Chemistry (47), 20 pp 9408-9421, Published

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Nuclear magnetic resonance spectroscopic analysis of the evolution of peroxidation products arising from culinary oils exposed to thermal oxidation: an investigation employing ┬╣H and ┬╣H-┬╣H COSY and TOCSY techniques

Ampem, Gilbert, Gresley, Adam Le, Grootveld, Martin and Naughton, Declan P., 2022, Foods (11), 13, Published

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Investigation of the formation of squalene oligomers exposed to ultraviolet light and changes in the exposed squalene as a potential skin model

Zecchini, Matteo, Lucas, Robert A., Robertson, Cameron, Coban, Tomris, Thatti, Ravtej and Gresley, Adam Le, 2022, Molecules (27), 11, Published

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The impact of partial oil substitution and trace metal ions on the evolution of peroxidation products in thermally stressed culinary oils

Ampem, Gilbert, Gresley, Adam Le, Grootveld, Martin, De Mars, Simon and Naughton, Declan P., 2022, Food Chemistry (375), Published

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Editorial: dietary lipid oxidation and fried food toxicology

Grootveld, Martin, Addis, Paul B. and Le Gresley, Adam, 2022, Frontiers in Nutrition (9), Published

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Fructose malabsorption: causes, diagnosis and treatment

Benardout, Miles, Le Gresley, Adam, Elshaer, Amr and Wren, Stephen P., 2022, British Journal of Nutrition (127), 4 pp 481-489, Published

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A proof-of-concept study utilising 2D NMR spectrometry for in situ characterisation and quantitation of key biomarkers and actives in tape stripped ex vivo human skin

Robertson, Cameron, Raj, Nidhin, Lucas, Robert, Coban, Tomris and Gresley, Adam Le, 2022, Talanta (237), Published

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The role of polydimethylsiloxane in suppressing the evolution of lipid oxidation products in thermo-oxidised sunflower oil: influence of stirring processes

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P., 2021, Frontiers in Nutrition (8), Published

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Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)

Goenaga Infante, Heidi, Warren, John, Chalmers, John, Dent, Geoffrey, Todoli, Jose Luis, Collingwood, Joanna, Telling, Neil, Resano, Martin, Limbeck, Andreas, Schoenberger, Torsten, Hibbert, D. Brynn, LeGresley, Adam, Adams, Kristie and Craston, Derek, 2021, Pure and Applied Chemistry (93), 6 pp 647-776, Published

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Thiazolidinediones: an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus

Long, Nathan, Le Gresley, Adam and Wren, Stephen P., 2021, ChemMedChem (16), 11 pp 1717-1736, Published

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Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard and LeGresley, Adam, 2021, MedChemComm (5) pp 751-757, Published

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Sunscreens containing cyclodextrin inclusion complexes for enhanced efficiency: a strategy for skin cancer prevention

Dahabra, Layan, Broadberry, Grace, Le Gresley, Adam, Najlah, Mohammad and Khoder, Mouhamad, 2021, Molecules (26), 6, Published

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"Real-world" evaluation of lipid oxidation products and trace metals in French fries from two chain fast-food restaurants

Le Gresley, Adam, Ampem, Gilbert, De Mars, Simon, Grootveld, Martin and Naughton, Declan P., 2021, Frontiers in Nutrition (8), Published

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Determination of metabolic activity in planktonic and biofilm cells of Mycoplasma fermentans and Mycoplasma pneumoniae by nuclear magnetic resonance

Awadh, Ammar A., Le Gresley, Adam, Forster-Wilkins, Gary, Kelly, Alison F. and Fielder, Mark D., 2021, Scientific Reports (11), Published

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Synthesis and initial evaluation of a novel fluorophore for selective FMDV 3C Protease detection

Malik, Samerah, Sinclair, Alex, Ryan, Ali and Le Gresley, Adam, 2020, Molecules (25), 16, Published

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Evaluations of the peroxidative susceptibilities of cod liver oils by a ┬╣H NMR analysis strategy: peroxidative resistivity of a natural collagenous and biogenic amine-rich fermented product

Percival, Benita C., Wann, Angela, Zbasnik, Richard, Schlegel, Vicki, Edgar, Mark, Zhang, Jie, Ampem, Gilbert, Wilson, Philippe, Le Gresley, Adam, Naughton, Declan and Grootveld, Martin, 2020, Nutrients (12), 3, Published

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Scope and limitations of nuclear magnetic resonance techniques for characterisation and quantitation of vitamin D in complex mixtures

Robertson, Cameron, Lucas, Robert A. and Le Gresley, Adam, 2020, Skin Research and Technology (26), 1 pp 112-120, Published

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Synthesis and spectral properties of novel Singapore Green analogues for protease detection

Bywaters, Luke and Le Gresley, Adam, 2020, Scientific Reports (10), Published

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Characterisation of peroxidation products arising from culinary oils exposed to continuous and discontinuous thermal degradation processes

Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin, Percival, Benita C. and Naughton, Declan P., 2019, Food and Function (10) pp 7952-7966, Published

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New insights into the cystine-sulfite reaction

Zecchini, Matteo, Lucas, Robert and Le Gresley, Adam, 2019, Molecules (24), 13, Published

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Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil

Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean Marie R., Robinson, Joshua and O'Leary, Shane, 2019, Journal of Analytical and Applied Pyrolysis (140) pp 281-289, Published

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A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis

Le Gresley, Adam and Peron, Jean Marie R., 2019, Food Chemistry (275) pp 385-389, Published

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Biological activities for 'Ficus carica' latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers

Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana and Ashrafi, G. Hossein, 2019, Scientific Reports (9), 1013, Published

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A life cycle assessment of options for producing synthetic fuel via pyrolysis

Vienescu, D. N., Wang, J., Le Gresley, A. and Nixon, J. D., 2018, Bioresource Technology (249) pp 626-634, Published

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Fatty acid based microemulsions to combat ophthalmia neonatorum caused by 'Neisseria gonorrhoeae' and 'Staphylococcus aureus'

Butt, Ummara, ElShaer, Amr, Snyder, Lori A.S., Al-Kinani, Ali A., Le Gresley, Adam and Alany, Raid G., 2018, Nanomaterials (8), 1, Published

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Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of 'Staphylococcus aureus'

Bywaters, Luke, Mulcahy-Ryan, Lauren, Fielder, Mark, Sinclair, Alex and Le Gresley, Adam, 2017, Molecular and Cellular Probes (36) pp 1-9, Published

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A preliminary characterisation of de novo lipogenesis in pancreatic (Capan-1) and liver (HepG2) cancer cell lines

Lambri, N., Snabaitis, A., Le Gresley, A., Modjtahedi, H. and Stolinski, M., 2016, European Journal of Cancer (61), S1 pp S106, Published

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Validating heteronuclear 2D quantitative NMR

Fardus-Reid, Fahmina, Warren, John and Le Gresley, Adam, 2016, Analytical Methods (8), 9 pp 2013-2019, Published

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Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents.

Le Gresley, A., Gudivaka, V., Carrington, S., Sinclair, A. and Brown, J. E., 2016, Organic and Biomolecular Chemistry (14) pp 3069-3079, Published

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The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries

Le Gresley, Adam, Simpson, Emma, Sinclair, Alex J., Williams, Neil, Burnett, Gary R., Bradshaw, Dave J. and Lucas, Robert A., 2015, Analytical Methods (7), 6, Published

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Bias and uncertainty in non-ideal qNMR Analysis

Le Gresley, Adam, Fardus, Fahmina and Warren, John, 2015, Critical Reviews in Analytical Chemistry (45), 4 pp 300-10, Published

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Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments.

Sinclair, Alex, Mulcahy, Lauren E., Geldeard, Lynsey, Malik, Samerah, Fielder, Mark D. and Le Gresley, Adam, 2013, Journal of Cystic Fibrosis (11), 20 pp 3307-3313, Published

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Phenolic promiscuity in the cell nucleus – epigallocatechin gallate (EGCG) and theaflavin-3,3′-digallate from green and black tea bind to model cell nuclear structures including histone proteins, double stranded DNA and telomeric quadruplex DNA

Mikutis, Gediminas, Karaköse, Hande, Jaiswal, Rakesh, LeGresley, Adam, Islam, Tuhidul, Fernandez-Lahore, Marcelo and Kuhnert, Nikolai, 2013, Food and Function (4), 2 pp 328-337, Published

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The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction

Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam, 2012, Tetrahedron Letters (53), 33 pp 4280-4282, Published

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The application of high resolution diffusion NMR to the analysis of manuka honey

Gresley, Adam Le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D., 2012, Food Chemistry (135), 4 pp 2879-86, Published

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Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays

Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza, Lafon, Shehri and Sinclair, Alex, 2011, MedChemComm (2), 6 pp 466-470, Published

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Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands

Le Gresley, Adam, Abdullah, Ammara, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafon, Shehri, 2010, Synthetic Communications (41), 16 pp 2483-2492, Published

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The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries

Le-Gresley, A and Kuhnert, N, 2010, Journal of Chemical Research (2) pp 61-67, Published

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Synthesis of upper rim calix[4]arene carcerands

Kuhnert, Nikolai and Le-Gresley, Adam, 2008, Tetrahedron Letters (49), 7 pp 1274-1276, Published

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Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer

Kuhnert, Nikolai, Le-Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana, 2007, Journal of Labelled Compounds and Radiopharmaceuticals (50), 13 pp 1215-1223, Published

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Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes

Kuhnert, Nikolai and Le-Gresley, Adam, 2005, Organic and Biomolecular Chemistry (3), 11 pp 2175-2182, Published

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The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries

Kuhnert, Nikolai and Le-Gresley, Adam, 2005, Tetrahedron Letters (46), 12 pp 2059-2062, Published

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The synthesis of tetra-acrylamido-calix[4]arene capsules

Kuhnert, Nikolai and Le-Gresley, Adam, 2003, Chemical Communications (19) pp 2426-2427, E-pub ahead of print

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On the scope and limitations of the Heck reaction of upper rim tetraiodocalix[4]arenes

Kuhnert, Nikolai and Le Gresley, Adam, 2001, Perkin Transactions 1 (24) pp 3393-3398, E-pub ahead of print

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Bicyclic 5-5 systems: five heteroatoms 2:3 and six heteroatoms 3:3

Le Gresley, Adam (2022). In: Al-dabbagh, Fawaz, (eds.), Amsterdam: pp 120-134 [Published]

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Quantification and identification of compounds by qNMR and a quantitative PSYCHE NMR method

Durrant, Arija, Peron, Jean-Marie R, Le Gresley, Adam and Langat, Moses K(2023). [Published]

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Identification and quantification of isolated medicinal compounds by PSYCHE NMR and DOSY NMR

Durrant, Arija, Peron, Jean-Marie, Le Gresley, Adam and Langat, Moses(2022). [Published]

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Optimization and uncertainty budgets of externally standardised NMR assays

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie(2011). [Published]

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Anti-cancer drugs: telomeres and cell senescence

Le Gresley, Adam(2009). [Published]

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The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR

Le Gresley, Adam, Gollapalli, Uma and Ghosh, Uttam(2009). [Published]

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The synthesis of novel calix[4]arene tetra-acrylates and their potential use as macrocyclic platforms in the development of static and dynamic combinatorial libraries using reversible imine formation.

Le Gresley, Adam and Kuhnert, Nikolai(2009). [Published]

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Rhodamine based fluorescent probe for coagulase activity and detection of coagulase producing bacterial strains

Sinclair, Alex, Fielder, Mark and Le Gresley, Adam (2013). [Published]

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