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Bacterial pathogens have been disastrous entity responsible for infection and death of millions of people. They are versatile in mode of action and living behaviour which leads them to become successful invaders. One of their most powerful tools is their effector proteins by which they control over host Rab GTPases. Rab GTPases are essential for the membrane trafficking and related cell defence functions including pathogen phagocytosis vesicle formation tethering transportation and fusion with lysosome. Bacterial effector proteins manipulate the Rab GTPases for replication, apoptosis, cytokines, and the autophagy process. Proposed research project focuses on the study of bacterial proteins and how they manipulate the Rab GTPases. Bacterial proteins and their complexes with Rab GTPases will be analyzed on molecular and structural basis. Successful compilation of this subject area will open a new era for development of structure based therapeutics, which is very cost effective. Solving the structural query of pathogenic bacterial proteins and their complexes with Rab GTPases will be a steppingstone towards the development of new antimicrobial drugs.
Subject area of life science is my core area of interest. Studying the tiny details of living things has always been my passion. I did my undergraduate degree in life sciences during my final semester, I did a research report which created my interest towards research. For my postgraduate I chose Molecular Biology as a major subject for my research thesis and worked with fungal immunomodulatory proteins and antibacterial activity of fungal proteins. I successfully completed my thesis and was awarded with a 1st class degree. I have also published some part of my research work and have presented my work in conferences and seminars. I have been a member of many science societies. My PhD proposed work is related to the field of Molecular biology, Biophysics, and Biochemistry. I am enthusiastic to study the structural properties of Bacterial pathogenic Proteins. This will fulfil my quest in the realm of Life sciences.