Mr Vishal Satikuvar

Research project: Synthesis and Evaluation for Antimicrobial Activity of Curcumin Derivatives and Related Compounds

Abstract

According to the World Health Organization antimicrobial resistance (AMR) is one of the top 10 world health threats. With the emergence of multi drug resistant microbes there is need for research. In 2019 an estimated 4.95 million deaths were caused by AMR. As the world becomes more health-conscious turmeric has become a staple in people's diet. Turmeric contains the bioactive compound curcumin. Dating back 4000 years turmeric was used for its antimicrobial and anti-inflammatory properties and is of interest for this project. Curcumin has been known to be the breaker of resistance due to its ability to lower the Minimum Inhibitory Concentration of ineffective antibiotics. The aim of this research is to synthesize a library of curcumin derivatives with similar structures to curcumin using a range of synthetic reactions. Once synthesized the compounds will be evaluated for their antimicrobial activity using the antibacterial susceptibility assay as well as by determining their MIC/MBC. 

  • Research degree: MSc by Research
  • Title of project: Synthesis and Evaluation for Antimicrobial Activity of Curcumin Derivatives and Related Compounds
  • Research supervisor: Dr Sianne Schwikkard
  • Other research supervisor: Dr Alison Kelly

Biography

I completed my BSc in Pharmaceutical Science at Kingston University. I have a keen interest in medicinal chemistry and my undergraduate project was looking at ' Piperidone derivatives as potential acetylcholinesterase inhibitors'. I also have carried out a SADRAS project which was looking at learning styles and how they were effected due to the pandemic. I have also worked as a vaccinator for St John's Ambulance delivering life saving covid vaccines. This work has inspired me to go down the route of research and be a part of life changing medicine.  

Areas of research interest

  • Organic Synthesis
  • Natural Products
  • Medicinal Chemistry

Qualifications

  • BSc in Pharmaceutical Science, Kingston University, UK