Dr Hachemi Kadri
Faculties, departments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Pharmacy
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Senior Lecturer in Pharmaceutical Chemistry
- Email:
- [email protected]
About
I joined Kingston University, London in January 2022 where I currently hold the position of Senior Lecturer in Pharmaceutical Chemistry. Prior to this, I was awarded the prestigious MRC GCRF Fellowship and was appointed as an Assistant Professor (Research) at the Chemistry Department, Durham University (January 2019-December 2021) where I also was a partner in the Global Network for the Neglected Tropical Diseases initiative. My MRC GCRF Fellowship research focused on developing innovative chemical approaches and tools to validate novel targets in Chagas disease and Leishmaniasis.
I completed my MPharm (Hons) degree at the University of Nottingham followed by a PhD in Medicinal Chemistry and Drug Design at the University of Cardiff, where I worked on the design, synthesis, and biological evaluation of novel anti-cancer agents. After my PhD, I worked on several drug discovery projects in key therapeutic areas including immuno-oncology, neurodegenerative and cardiovascular diseases at the University of Birmingham and later at Cardiff University
Qualifications
- Ph.D. in Medicinal Chemistry and Drug Design, Cardiff University
- MPharm (Hons) degree at the University of Nottingham
- GPhC registered pharmacist
Domains
Research in The Kadri Lab focuses on developing innovative chemical approaches for the discovery of novel therapeutics to address unmet global health needs particularly neglected tropical diseases (NTDs). Research is multidisciplinary spanning the fields of chemical biology, medicinal chemistry, computer-aided drug design, high throughput screening, protein crystallography, and biochemistry.
Funding:
- 2022-2023: RSC Research Fund grant
- 2019-2021: GCRF Fellowship award.
Specialisms
- Infectious diseases target validation and drug discovery
- Modulation of protein-protein interactions for therapeutic purposes
- Computer-aided drug design of novel therapeutic compounds
Publications
Lactate monitoring using fluorescence with stable boronic acid-functionalized nanoparticles from Polymerization-Induced Self-Assembly (PISA)
Balouchi, Morvarid, Liu, Zixiao, Ishizuka, Fumi, Bear, Joseph, Kadri, Hachemi, Zetterlund, Per B. and Aldabbagh, Fawaz, 2026, Langmuir, E-pub ahead of print
Targeting kinetoplastid parasites with ProTide prodrugs: a proof‐of‐concept study
Lowe, Silvester, Satikuvar, Vishal, Syeda, Tanjia M., Cal, Monica, Mäser, Pascal, Kaiser, Marcel and Kadri, Hachemi, 2026, ChemMedChem (21), 7, Published
From solid dispersions to enzyme-responsive nanocarriers: whey protein isolate nanoparticles for enhanced curcumin encapsulation and targeted delivery
Megahed, Marwa, Patel, Jaina, Najlah, Mohammad, Kadri, Hachemi and Khoder, Mouhamad, 2026, Pharmaceutics (18), 5, Published
Albumin nanoparticles in cancer therapeutics: clinical Status, challenges, and future directions
Kadri, Hachemi, Alshatfa, Mesk, Alsalloum, Feras Z., Elhissi, Abdelbary, Daou, Anis and Khoder, Mouhamad, 2025, Pharmaceutics (17)pp 1290, Published
Nucleoside analogues for chagas disease and leishmaniasis therapy: current status and future perspectives
Nwoke, Emmanuel Awucha, Lowe, Silvester, Aldabbagh, Fawaz, Kalesh, Karunakaran and Kadri, Hachemi, 2024, Molecules (29), 22, Published
Aryloxy diester phosphonamidate prodrugs of phosphoantigens (ProPAgens) as potent activators of V╬│9/V╬┤2 T-cell immune responses
Kadri, Hachemi, Taher, Taher E., Xu, Qin, Sharif, Maria, Ashby, Elizabeth, Bryan, Richard T., Willcox, Benjamin E. and Mehellou, Youcef, 2020, Journal of Medicinal Chemistry (63), 19pp 11258-11270, Published
Aryloxy triester phosphoramidates as phosphoserine prodrugs: a proof of concept study
Miccoli, Ageo, Dhiani, Binar A., Thornton, Peter J., Lambourne, Olivia A., James, Edward, Kadri, Hachemi and Mehellou, Youcef, 2020, ChemMedChem (15), 8pp 671-674, Published
The photosensitising clinical agent verteporfin is an inhibitor of SPAK and OSR1 kinases
AlAmri, Mubarak A., Kadri, Hachemi, Alderwick, Luke J., Jeeves, Mark and Mehellou, Youcef, 2018, ChemBioChem (19), 19pp 2072-2080, Published
C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25
Mehellou, Youcef, Alamri, Mubarak A., Dhiani, Binar A. and Kadri, Hachemi, 2018, Biochemical and Biophysical Research Communications (503), 3pp 1868-1873, Published
Niclosamide: a drug with many (re)purposes
Kadri, Hachemi, Lambourne, Olivia A. and Mehellou, Youcef, 2018, ChemMedChem (13), 11pp 1088-1091, Published
The anthelmintic drug niclosamide and its analogues activate the Parkinson's disease associated protein kinase PINK1
Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef and Muqit, Miratul M.K., 2018, ChemBioChem (19), 5pp 425-429, Published
BTN3A1 discriminates ╬│╬┤ T cell phosphoantigens from nonantigenic small molecules via a conformational sensor in its B30.2 domain
Salim, Mahboob, Knowles, Timothy J., Baker, Alfie T., Davey, Martin S., Jeeves, Mark, Sridhar, Pooja, Wilkie, John, Willcox, Carrie R., Kadri, Hachemi, Taher, Taher E., Vantourout, Pierre, Hayday, Adrian, Mehellou, Youcef, Mohammed, Fiyaz and Willcox, Benjamin E., 2017, ACS Chemical Biology (12), 10pp 2631-2643, Published
WNK signaling inhibitors as potential antihypertensive drugs
AlAmri, Mubarak A., Kadri, Hachemi, Dhiani, Binar A., Mahmood, Shumail, Elzwawi, Abdulrahman and Mehellou, Youcef, 2017, ChemMedChem (12), 20pp 1677-1686, Published
Rafoxanide and closantel inhibit SPAK and OSR1 kinases by binding to a highly conserved allosteric site on their C-terminal domains
AlAmri, Mubarak A., Kadri, Hachemi, Alderwick, Luke J., Simpkins, Nigel S. and Mehellou, Youcef, 2017, ChemMedChem (12), 9pp 639-645, Published
Kinetin riboside and its ProTides activate the Parkinson's disease associated PTEN-induced putative kinase 1 (PINK1) independent of mitochondrial depolarization
Osgerby, Laura, Lai, Yu Chiang, Thornton, Peter J., Amalfitano, Joseph, Le Duff, Cécile S., Jabeen, Iqra, Kadri, Hachemi, Miccoli, Ageo, Tucker, James H.R., Muqit, Miratul M.K. and Mehellou, Youcef, 2017, Journal of Medicinal Chemistry (60), 8pp 3518-3524, Published
Towards the development of small-molecule MO25 binders as potential indirect SPAK/OSR1 kinase inhibitors
Kadri, Hachemi, Alamri, Mubarak A., Navratilova, Iva H., Alderwick, Luke J., Simpkins, Nigel S. and Mehellou, Youcef, 2017, ChemBioChem (18), 5pp 460-465, Published
Nucleoside phosphate and phosphonate prodrug clinical candidates
Thornton, Peter J., Kadri, Hachemi, Miccoli, Ageo and Mehellou, Youcef, 2016, Journal of Medicinal Chemistry (59), 23pp 10400-10410, Published
Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles
Karaaslan, Cigdem, Kadri, Hachemi, Coban, Tulay, Suzen, Sibel and Westwell, Andrew D., 2013, Physikalische Medizin Rehabilitationsmedizin Kurortmedizin (23), 9pp 2671-2674, Published
The design, synthesis and antitumour evaluation of novel small molecule inhibitors of the Dishevelled PDZ domain
Kadri, H., Dale, T.C., Ewan, K.B.R. and Westwell, A.D., 2008, European Journal of Cancer Supplements (6), 12, Published
Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648)
Aiello, Stefania, Wells, Geoffrey, Stone, Erica L., Kadri, Hachemi, Bazzi, Rana, Bell, David R., Stevens, Malcolm F.G., Matthews, Charles S., Bradshaw, Tracey D. and Westwell, Andrew D., 2008, Journal of Medicinal Chemistry (51), 16pp 5135-5139, Published
The development of pro-apoptotic cancer therapeutics
Ziedan, Noha I., Kadri, Hachemi and Westwell, Andrew D., 2008, Mini-Reviews in Medicinal Chemistry (8), 7pp 711-718, Published
Synthesis and antitumour evaluation of novel 2- phenylbenzimidazoles
Kadri, Hachemi, Matthews, Charles S., Bradshaw, Tracey D., Stevens, Malcolm F.G. and Westwell, Andrew D., 2008, Journal of Enzyme Inhibition and Medicinal Chemistry (23), 5pp 641-647, Published
Impact of academic peer mentoring for pharmaceutical and chemical sciences foundation degree students at Kingston University
Mason, Thuy, Kadri, Hachemi, Mukhtar, Rahila and Khoder, Mouhamad(2024). [Published]