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I completed my PhD in Natural Products Chemistry at the University of Kwazulu-Natal, South Africa in 1998. The complexity and beauty of natural compounds fascinated me and has led to a life-long pursuit of both novel compounds from plant sources as well as the synthesis of these compounds. Plants can produce a range and diversity of chemical entities unparalleled by synthetic efforts and displaying an unsurprising range of biological activities. My research career was developed through a post-doctoral fellowship at Virginia Tech under Professor David Kingston, followed by a post-doctoral position at the Rand Academic University under Professor Fanie Van Heerden. I spent a short 18 months working in the petrochemical industry for Sasol Technology before relocating to the UK and working for Professor Keith Jones at Kingston University.
I spent 11 years as a part-time lecturer at Kingston University and research associate at Surrey University before I joined Kingston University full time in September 2015.
While at the University of Surrey, I was awarded a Daphne Jackson Fellowship and I have maintained links with the Daphne Jackson Trust.
My background in natural products and synthetic organic chemistry has allowed me the opportunity to teach across all three departments in the School of Life Sciences, Pharmacy and Chemistry. This had given me an appreciation for the challenges faced by students across the school.
Having lived and worked in three different countries in very different parts of the world (South Africa, America and UK) gives me a broad experience and sympathy for students from a diverse range of backgrounds, facing a diverse range of challenges in their education.
Having completed the AFHEA and the FHEA has provided me with the necessary skills to engage and challenge different students with different educational needs.
I have been the lead for the Personal Tutor Scheme for the Department of Chemistry and Pharmaceutical Science since 2018. The personal and tailored support a personal tutor can provide for a student has a positive impact on their university experience and can significantly impact on their academic success. In addition it is essential that the academic staff acting as personal tutors have adequate support as the role can be challenging.
Keeping on the fore front of my research field positively impacts on my teaching as I am better able to inspire my students with relevant and novel research in their chosen fields of study.
I have an interest in bioactive natural products, both isolated from plant sources as well as their synthetic analogues. I have a particular interest in compounds known as homoisoflavonoids, isolated primarily from the Hyacinthaceae (Asparagaceae). These compounds have a range of interesting biological activities including anti-cancer, anti-inflammatory and anti-angiogenic effects. They have been identified as potential new sources of treatment for macular degeneration and other eye diseases characterised by angiogenesis.
My work on macular degeneration is carried out in collaboration with the University of Surrey and the Glick Eye Institute, University of Indiana. The work has been highlighted by this article in the Daily mail:
In addition, I am collaborating with Professor Raid Alany and Dr Ali Al-Kinani to look at the effect of these compounds on diseases of the cornea. We are looking at other natural polyphenolic compounds in this regard.
I am also working with Dr Alison Kelly of Kingston University on the effect of natural products and synthetic analogues of natural products on antibiotic resistant bacteria.
I am first supervisor for 1 PhD student and second supervisor for 4 other PhD students. I have 2 completions for MSc by research as first supervisor and 1 as second supervisor as well as 1 PhD completion as additional supervisor (University of Surrey)
I have an ongoing collaboration with The Royal Botanic Gardens, Kew. We are looking at bioactive compounds from East African medicinal plants and have an active collaboration with Egerton University in Kenya.
Langat, Moses K., Dlova, Ncoza C., Mulcahy-Ryan, Lauren E., Schwikkard, Sianne L., Opara, Elizabeth I., Crouch, Neil R., Hiles, Jacob D. and Mulholland, Dulcie A. (2020) The effect of isolates from Cassipourea flanaganii (Schinz) alston, a plant used as a skin lightning agent, on melanin production and tyrosinase inhibition. Journal of Ethnopharmacology, ISSN (print) 0378-8741 (Epub Ahead of Print)
Whitmore, Hannah, Sishtla, Kamakshi, Knirsch, Walter, Andriantiana, Jacky L., Schwikkard, Sianne, Mas-Claret, Eduard, Nassief, Sarah M., Isyaka, Sani M., Corson, Timothy W. and Mulholland, Dulcie A. (2020) Bufadienolides and anti-angiogenic homoisoflavonoids from 'Rhodocodon cryptopodus', 'Rhodocodon rotundus' and 'Rhodocodon cyathiformis'. Fitoterapia, 141, p. 104479. ISSN (print) 0367-326X
Schwikkard, Sianne, Whitmore, Hannah, Sishtla, Kamakshi, Sulaiman, Rania S., Shetty, Trupti, Basavarajappa, Halesha D., Waller, Catherine, Alqahtani, Alaa, Frankemoelle, Lennart, Chapman, Andy, Crouch, Neil, Wetschnig, Wolfgang, Knirsch, Walter, Andriantiana, Jacky, Mas-Claret, Eduard, Langat, Moses K., Mulholland, Dulcie and Corson, Timothy W. (2019) The antiangiogenic activity of naturally occurring and synthetic homoisoflavonoids from the Hyacinthaceae (sensu APGII). Journal of Natural Products, 82(5), pp. 1227-1239. ISSN (print) 0163-3864
Takou, Dieudonne M., Kamdem Waffo, Alain F., Langat, Moses K., Wansi, Jean D., Mulcahy-Ryan, Lauren E., Schwikkard, Sianne L., Opara, Elizabeth I., Mas-Claret, Eduard and Mulholland, Dulcie A. (2019) Melanin production inhibitors from the West African 'Cassipourea congoensis'. Planta Medica International Open, 6(02), e50-e56. ISSN (online) 2199-157X
Schwikkard, Sianne, Whitemore, Hannah, Corson, Timothy, Sishtla, Kamakshi, Langat, Moses K., Carew, Mark and Mulholland, Dulcie A. (2018) Antiangiogenic activity and cytotoxicity of triterpenoids and homoisoflavonoids from 'Massonia pustulata' and 'Massonia bifolia'. Planta Medica, 84, pp. 638-644. ISSN (print) 0032-0943
Aldhaher, Areej, Langat, Moses, Ndunda, Beth, Chirchir, Denis, Midiwo, Jacob O., Njue, Alice, Schwikkard, Sianne, Carew, Mark and Mulholland, Dulcie (2017) Diterpenoids from the roots of 'Croton dichogamus' Pax. Phytochemistry, 144, pp. 1-8. ISSN (print) 0031-9422
Schwikkard, Sianne, Alqahtani, Alaa, Knirsch, Walter, Wetschnig, Wolfgang, Jaksevicius, Andrius, Opara, Elizabeth, Langat, Moses, Andriantiana, Jackie and Mulholland, Dulcie (2017) Phytochemical investigations of three Rhodocodon (Hyacinthaceae Sensu APG II) species. Journal of Natural Products, 80(1), pp. 30-37. ISSN (print) 0163-3864
Schwikkard, Sianne L. and Mulholland, Dulcie A. (2014) Useful Methods for Targeted Plant Selection in the Discovery of Potential New Drug Candidates. Planta Medica, 80(14), pp. 1154-1160. ISSN (print) 0032-0943
Mulholland, Dulcie A., Schwikkard, Sianne L. and Crouch, Neil R. (2013) The chemistry and biological activity of the Hyacinthaceae. Natural Product Reports, 30(9), pp. 1165-1210. ISSN (print) 0265-0568
Morgan, David H., Schwikkard, Sianne L., Dixon, John T., Nair, Jerald J. and Hunter, Roger (2003) The Effect of Aromatic Ethers on the Trimerisation of Ethylene using a Chromium Catalyst and Aryloxy Ligands. Advanced Synthesis & Catalysis, 345(8), pp. 939-942. ISSN (print) 1615-4150
Morgan, David H., Schwikkard, Sianne L., Dixon, John T., Nair, Jerald J. and Hunter, Roger (2003) The effect of aromatic ethers on the trimerisation of ethylene using a chromium catalyst and aryloxy ligands. Advanced Synthesis & Catalysis, 345(8), pp. 939-942. ISSN (print) 1615-4150
Mulholland, Dulcie A., Schwikkard, Sianne L., Sandor, Peter and Nuzillard, Jean M. (2000) Delevoyin C, a tetranortriterpenoid from Entandrophragma delevoyi. Phytochemistry, 53(4), pp. 465-468. ISSN (print) 0031-9422
Mulholland, Dulcie A., Randrianarivelojosia, Milijaona, Lavaud, Catherine, Nuzillard, Jean-Marc and Schwikkard, Sianne L. (2000) Limonoid derivatives from Astrotrichilia voamatata. Phytochemistry, 53(1), pp. 115-118. ISSN (print) 0031-9422
Schwikkard, Sianne, Zhou, Bing-Nan, Glass, Thomas E., Sharp, Jessica L., Mattern, Michael R., Johnson, Randall K. and Kingston, David G. I. (2000) Bioactive Compounds from Combretum erythrophyllum. Journal of Natural Products, 63(7), pp. 1045-1046. ISSN (print) 0163-3864
Schwikkard, Sianne, Zhou, Bing-Nan, Glass, Thomas E., Sharp, Jessica L., Mattern, Michael R., Johnson, Randall K. and Kingston, David G. I. (2000) Bioactive Compounds from Combretum erythrophyllum. Journal of Natural Products, 63(4), pp. 457-460. ISSN (print) 0163-3864
Schwikkard, S., James, E. E., Mulholland, D. A., Knirsch, W., Corson, T., Opara, E. and Jaksevicius, A. (2015) Novel, bioactive homoisoflavonoids from a Madagascan Rhodocodon species (Hyacinthaceae, sensu APG II). In: 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA2015); 23 - 27 Aug 2015, Szeged, Hungary. (Unpublished)
I am currently serving on the committee assessing the applications for the RSC Research Fund.
I have maintained links with the Daphne Jackson Trust and have given a number of talks at events they have organised on employability and getting people back to work in research after a career break. The Trust provides Fellowships for people who have had to take a career break to allow them to restart their research career. It provides vital opportunities for people to update their skills and allow them to complete on an equal playing field.
I am the lead for the Personal Tutor Scheme for the Department of Chemistry and Pharmaceutical Science.