Dr Ahmed Elbediwy

About

I joined Kingston University as Lecturer in Clinical Biochemistry in 2019, following a successful postdoctoral research position in the Francis Crick Institute, London. I obtained my PhD in 2013 from University College, London under the supervision of Prof. Karl Matter in Cell Biology and Biochemistry looking at essential signalling pathways in Cancer. My Postdoctoral research was with Dr Barry Thompson at the Francis Crick Institute, London looking at growth control mechanisms in the context of cancer initiation. During my time at the Crick I developed my teaching with a joint collaboration with UCL and was awarded an AFHEA from this venture. During my time in the Crick I also made strong industrial collaborations with GSK by jointly working on a chemical screen to identify drugs involved in cancer inhibition. When I joined Kingston i quickly established myself as an integral part of the Biomolecular Science teaching team and obtained my FHEA within the first year, before becoming a Senior Lecturer and course leader for BSc Biochemistry in 2020. I teach on a range of Biochemistry, Biomedical Sciences and Biological Science courses. My current research interest focuses on various input signals in the context of cancer initiation and natural compounds and their effects on oncogenes as well as how metabolism can affect signalling pathways in cancer.

Academic responsibilities

Senior Lecturer and Course Leader BSc Biochemistry

Qualifications

  • Advance HE Online Professional Development Course for External Examiners (2020)
  • Fellow of the HEA (2019)
  • Associate Fellow of the HEA (2018)
  • DPhil in Molecular Cell Biology (University College London) (2013)
  • B.Sc (Hons) in Molecular Biology (Queen Mary, University of London) (2005)

Teaching and learning

Course Leader 

  • BSc Biochemistry

Module Leader 

  • LS6005 - Clinical Chemistry and Haematology

Undergraduate courses taught

Postgraduate courses taught

Research

My research focuses mostly on the initiation and treatment of cancer. This can be investigated on the molecular level as well as with the use of therapeutic compounds:

Some project titles include:

Signalling pathways in cancer initiation

Naturally occurring compounds and cancer inhibition

The Extracellular Matrix and Disease

Effect of Metabolism on signalling pathways

Research students:

  • First supervisor PhD student: Ms Simge Karagil
  • Second supervisor MScR: Ms Khalisha Malik

Publications

Jump to: Article
Number of items: 20.

Article

Cobbaut, Mathias, Karagil, Simge, Bruno, Lucrezia, de Loza, Maria Del Carmen Diaz, Mackenzie, Francesca E, Stolinski, Michael and Elbediwy, Ahmed (2020) Dysfunctional mechanotransduction through the YAP/TAZ/Hippo pathway as a feature of chronic disease. Cells, 9(1), p. 151. ISSN (online) 2073-4409

Sidor, Clara, Borreguero-Munoz, Nerea, Fletcher, Georgina C, Elbediwy, Ahmed, Guillermin, Oriane and Thompson, Barry J (2019) Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability. eLIFE, 2019(8), e48601. ISSN (online) 2050-084X

Borreguero-Munoz, Nerea, Fletcher, Georgina C., Aguilar-Aragon, Mario, Elbediwy, Ahmed, Vincent-Mistiaen, Zoe I. and Thompson, Barry J. (2019) The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. PLoS Biology, 17(10), e3000509. ISSN (print) 1544-9173

Cobbaut, Mathias and Elbediwy, Ahmed (2019) First person – Mathias Cobbaut and Ahmed Elbediwy. Journal of Cell Science, 132(8), jcs231928. ISSN (print) 0021-9533

Elbediwy, Ahmed, Zhang, Yixiao, Cobbaut, Mathias, Riou, Philippe, Tan, Ray S., Roberts, Selene K., Tynan, Chris, George, Roger, Kjaer, Svend, Martin-Fernandez, Marisa L., Thompson, Barry J., McDonald, Neil Q. and Parker, Peter J. (2019) The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity. Journal of Cell Science, 132(8), p. 223743. ISSN (print) 0021-9533

Elbediwy, Ahmed (2018) First person – Ahmed Elbediwy. Journal of Cell Science, 131(22), ISSN (print) 0021-9533

Elbediwy, Ahmed, Vanyai, Hannah, Diaz-de-la-Loza, Maria-del-Carmen, Frith, David, Snijders, Ambrosius P. and Thompson, Barry J. (2018) Enigma proteins regulate YAP mechanotransduction. Journal of Cell Science, 131(22), jcs22178. ISSN (print) 0021-9533

Vincent-Mistiaen, Zoe, Elbediwy, Ahmed, Vanyai, Hannah, Cotton, Jennifer, Stamp, Gordon, Nye, Emma, Spencer-Dene, Bradley, Thomas, Gareth J, Mao, Junhao and Thompson, Barry (2018) YAP drives cutaneous squamous cell carcinoma formation and progression. eLife, 7, e33304. ISSN (online) 2050-084X

Elbediwy, Ahmed and Thompson, Barry J (2018) Evolution of mechanotransduction via YAP/TAZ in animal epithelia. Current Opinion in Cell Biology, 51, pp. 117-123. ISSN (print) 0955-0674

Aguilar-Aragon, Mario, Elbediwy, Ahmed, Foglizzo, Valentina, Fletcher, Georgina C, Li, Vivian S.W. and Thompson, Barry J. (2018) Pak1 kinase maintains apical membrane identity in epithelia. Cell Reports, 22(7), pp. 1639-1646. ISSN (online) 2211-1247

Soriano, Erika V., Ivanova, Marina E., Fletcher, Georgina, Riou, Philippe, Knowles, Philip P., Barnouin, Karin, Purkiss, Andrew, Kostelecky, Brenda, Saiu, Peter, Linch, Mark, Elbediwy, Ahmed, Kjær, Svend, O'Reilly, Nicola, Snijders, Ambrosius P, Parker, Peter J., Thompson, Barry J. and McDonald, Neil Q. (2016) aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization. Developmental Cell, 38(4), pp. 384-398. ISSN (print) 1534-5807

Elbediwy, Ahmed, Vincent-Mistiaen, Zoe I. and Thompson, Barry J. (2016) YAP and TAZ in epithelial stem cells : a sensor for cell polarity, mechanical forces and tissue damage. BioEssays, 38(7), pp. 644-653. ISSN (print) 0265-9247

Khanal, Ichha, Elbediwy, Ahmed, Diaz de la Loza, Maria Del Carmen, Fletcher, Georgina C. and Thompson, Barry J. (2016) Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia. Journal of Cell Science, 129(13), pp. 2651-2659. ISSN (print) 0021-9533

Elbediwy, Ahmed, Vincent-Mistiaen, Zoe I., Spencer-Dene, Bradley, Stone, Richard K., Boeing, Stefan, Wculek, Stefanie K., Cordero, Julia, Tan, Ee H., Ridgway, Rachel, Brunton, Val G., Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J. and Thompson, Barry J. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. ISSN (print) 0950-1991

Fletcher, Georgina C, Elbediwy, Ahmed, Khanal, Ichha, Ribeiro, Paulo S, Tapon, Nic and Thompson, Barry J (2015) The Spectrin cytoskeleton regulates the Hippo signalling pathway. The EMBO Journal, 34(7), pp. 940-954. ISSN (print) 0261-4189

Steed, Emily, Elbediwy, Ahmed, Vacca, Barbara, Dupasquier, Sebastien, Hemkemeyer, Sandra A., Suddason, Tesha, Costa, Ana C., Beaudry, Jean-Bernard, Zihni, Ceniz, Gallagher, Ewen, Pierreux, Christophe E., Balda, Maria S. and Matter, Karl (2014) MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. Journal of Cell Biology, 204(5), pp. 821-838. ISSN (print) 0021-9525

Zihni, Ceniz, Munro, Peter M. G., Elbediwy, Ahmed, Keep, Nicholas H., Terry, Stephen J., Harris, John, Balda, Maria S. and Matter, Karl (2014) Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. Journal of Cell Biology, 204(1), pp. 111-127. ISSN (print) 0021-9525

Terry, Stephen J., Elbediwy, Ahmed, Zihni, Ceniz, Harris, Andrew R., Bailly, Maryse, Charras, Guillaume T., Balda, Maria S. and Matter, Karl (2012) Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PLoS One, 7(11), e50188. ISSN (online) 1932-6203

Elbediwy, Ahmed, Zihni, Ceniz, Terry, Stephen J., Clark, Peter, Matter, Karl and Balda, Maria S. (2012) Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. Journal of Cell Biology, 198(4), pp. 677-693. ISSN (print) 0021-9525

Terry, Stephen J., Zihni, Ceniz, Elbediwy, Ahmed, Vitiello, Elisa, Leefa Chong San, Isabelle V., Balda, Maria S. and Matter, Karl (2011) Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nature Cell Biology, 13(2), pp. 159-166. ISSN (print) 1465-7392

This list was generated on Tue Sep 22 05:16:09 2020 BST.

Leadership and management

Course Leader of BSc Biochemistry (2020)

Social media

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