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Dr Ahmed Elbediwy

Lecturer in Clinical Biochemistry

About

I undertook my first degree at Queen Mary, University of London in Molecular Biology. My PhD was under the supervision of Prof. Karl Matter at UCL using cell culture to elucidate the mechanisms by which Rho GTPase signalling was regulated at cell-cell adhesions. My Postdoctoral research was with Dr Barry Thompson at the Francis Crick Institute, London looking at growth control mechanisms in the context of cancer initiation. The lab was solely working on Drosophila melanogaster as a model system when I first joined but I managed to integrate Mammalian models as part of the organisms used and now the lab focuses on Drosophila, cells culture and Mice. During my time at the Crick I developed my teaching with a joint collaboration with UCL and was awarded an AFHEA from this venture.  I also made strong collaborations with GSK. I joined Kingston in 2019 and my lab will focus on various input signals in the context of cancer initiation and natural compounds and their effects on oncogenes.

Areas of specialism

  • Cancer biology
  • Biochemistry
  • Cell biology
  • Mammalian cell culture
  • Growth control
  • Rho GTPase signalling
  • Cellular junctions
  • Hippo pathway

Qualifications

  • DPhil in Molecular Cell Biology (University College London)
  • B.Sc (Hons) in Molecular Biology (Queen Mary, University of London)

Professional membership

Associate Fellow of the Higher Education Academy

Member of the Royal Society of Biology

Research

Signalling pathways in cancer initiation

Naturally occuring compounds and cancer inhibition

The Extracellular Matrix and Disease

Effect of Metabolism on signalling pathways

Publications

Jump to: Article
Number of items: 17.

Article

Cobbaut, Mathias and Elbediwy, Ahmed (2019) First person – Mathias Cobbaut and Ahmed Elbediwy. Journal of Cell Science, 132(8), jcs231928. ISSN (print) 0021-9533

Elbediwy, Ahmed, Zhang, Yixiao, Cobbaut, Mathias, Riou, Philippe, Tan, Ray S., Roberts, Selene K., Tynan, Chris, George, Roger, Kjaer, Svend, Martin-Fernandez, Marisa L., Thompson, Barry J., McDonald, Neil Q. and Parker, Peter J. (2019) The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity. Journal of Cell Science, 132(8), p. 223743. ISSN (print) 0021-9533

Elbediwy, Ahmed (2018) First person – Ahmed Elbediwy. Journal of Cell Science, 131(22), ISSN (print) 0021-9533

Elbediwy, Ahmed, Vanyai, Hannah, Diaz-de-la-Loza, Maria-del-Carmen, Frith, David, Snijders, Ambrosius P. and Thompson, Barry J. (2018) Enigma proteins regulate YAP mechanotransduction. Journal of Cell Science, 131(22), jcs22178. ISSN (print) 0021-9533

Vincent-Mistiaen, Zoe, Elbediwy, Ahmed, Vanyai, Hannah, Cotton, Jennifer, Stamp, Gordon, Nye, Emma, Spencer-Dene, Bradley, Thomas, Gareth J, Mao, Junhao and Thompson, Barry (2018) YAP drives cutaneous squamous cell carcinoma formation and progression. eLife, 7, e33304. ISSN (online) 2050-084X

Elbediwy, Ahmed and Thompson, Barry J (2018) Evolution of mechanotransduction via YAP/TAZ in animal epithelia. Current Opinion in Cell Biology, 51, pp. 117-123. ISSN (print) 0955-0674

Aguilar-Aragon, Mario, Elbediwy, Ahmed, Foglizzo, Valentina, Fletcher, Georgina C, Li, Vivian S.W. and Thompson, Barry J. (2018) Pak1 kinase maintains apical membrane identity in epithelia. Cell Reports, 22(7), pp. 1639-1646. ISSN (online) 2211-1247

Soriano, Erika V., Ivanova, Marina E., Fletcher, Georgina, Riou, Philippe, Knowles, Philip P., Barnouin, Karin, Purkiss, Andrew, Kostelecky, Brenda, Saiu, Peter, Linch, Mark, Elbediwy, Ahmed, Kjær, Svend, O'Reilly, Nicola, Snijders, Ambrosius P, Parker, Peter J., Thompson, Barry J. and McDonald, Neil Q. (2016) aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization. Developmental Cell, 38(4), pp. 384-398. ISSN (print) 1534-5807

Elbediwy, Ahmed, Vincent-Mistiaen, Zoe I. and Thompson, Barry J. (2016) YAP and TAZ in epithelial stem cells : a sensor for cell polarity, mechanical forces and tissue damage. BioEssays, 38(7), pp. 644-653. ISSN (print) 0265-9247

Khanal, Ichha, Elbediwy, Ahmed, Diaz de la Loza, Maria Del Carmen, Fletcher, Georgina C. and Thompson, Barry J. (2016) Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia. Journal of Cell Science, 129(13), pp. 2651-2659. ISSN (print) 0021-9533

Elbediwy, Ahmed, Vincent-Mistiaen, Zoe I., Spencer-Dene, Bradley, Stone, Richard K., Boeing, Stefan, Wculek, Stefanie K., Cordero, Julia, Tan, Ee H., Ridgway, Rachel, Brunton, Val G., Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J. and Thompson, Barry J. (2016) Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development, 143(10), pp. 1674-1687. ISSN (print) 0950-1991

Fletcher, Georgina C, Elbediwy, Ahmed, Khanal, Ichha, Ribeiro, Paulo S, Tapon, Nic and Thompson, Barry J (2015) The Spectrin cytoskeleton regulates the Hippo signalling pathway. The EMBO Journal, 34(7), pp. 940-954. ISSN (print) 0261-4189

Steed, Emily, Elbediwy, Ahmed, Vacca, Barbara, Dupasquier, Sebastien, Hemkemeyer, Sandra A., Suddason, Tesha, Costa, Ana C., Beaudry, Jean-Bernard, Zihni, Ceniz, Gallagher, Ewen, Pierreux, Christophe E., Balda, Maria S. and Matter, Karl (2014) MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. Journal of Cell Biology, 204(5), pp. 821-838. ISSN (print) 0021-9525

Zihni, Ceniz, Munro, Peter M. G., Elbediwy, Ahmed, Keep, Nicholas H., Terry, Stephen J., Harris, John, Balda, Maria S. and Matter, Karl (2014) Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. Journal of Cell Biology, 204(1), pp. 111-127. ISSN (print) 0021-9525

Terry, Stephen J., Elbediwy, Ahmed, Zihni, Ceniz, Harris, Andrew R., Bailly, Maryse, Charras, Guillaume T., Balda, Maria S. and Matter, Karl (2012) Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PLoS One, 7(11), e50188. ISSN (online) 1932-6203

Elbediwy, Ahmed, Zihni, Ceniz, Terry, Stephen J., Clark, Peter, Matter, Karl and Balda, Maria S. (2012) Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. Journal of Cell Biology, 198(4), pp. 677-693. ISSN (print) 0021-9525

Terry, Stephen J., Zihni, Ceniz, Elbediwy, Ahmed, Vitiello, Elisa, Leefa Chong San, Isabelle V., Balda, Maria S. and Matter, Karl (2011) Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nature Cell Biology, 13(2), pp. 159-166. ISSN (print) 1465-7392

This list was generated on Fri Jul 19 04:36:38 2019 BST.
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