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I obtained my PhD on the genetics and pathophysiology of deafness from University of Oxford and MRC Harwell Mammalian Genetics Unit in 2006. During postdoctoral work I then researched neuromuscular biology at MRC Harwell, and neuronal development, regeneration and degeneration at UCL Institute of Ophthalmology.
I joined Kingston University in 2017 as Lecturer in Physiology and Pharmacology with a specialism in neuroscience.
My research interests are in neuronal development and regeneration, particularly in the peripheral nervous system and in the eye.
Senior Lecturer in Physiology and Pharmacology (Neuroscience)
I teach undergraduate and postgraduate physiology and pharmacology with a focus on neurobiology.
I also supervise postgraduate MScR and PhD research students in neurobiology topics.
Undergraduate module teaching:
My research interests are in the genetics and cell biology of neuronal development and neuronal regeneration, particularly in the peripheral nervous system and in the eye.
Current lab members:
Completed postgraduate students:
Internal research activities
Cattin AL, Burden JJ, Van Emmenis L, Mackenzie FE et al. Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves. Cell (2015).
Wiszniak S, Mackenzie FE, Anderson P, Kabbara S, Ruhrberg C, Schwarz Q. Neural crest cell-derived VEGF promotes embryonic jaw extension. PNAS (2015).
Mackenzie FE. & Ruhrberg, C. Diverse roles of VEGF-A in the nervous system. Development (2012).
Tillo M, Ruhrberg C, & Mackenzie, F. Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity. Cell Adhesion and Migration (2012).
Mackenzie FE, et al. Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse. Hum Mol Genet (2009)
Orme Merve, Ayse, Sobiecka, Pola, Remeškevičius, Vytautas, Taylor, Luke, Saskoy, Lili, Lawton, Scott, Jones, Ben P., Elwakeel, Ahmed, Mackenzie, Francesca E., Polycarpou, Elena, Bennett, Jason and Rooney, Brian (2022) Metabolites of cannabis induce cardiac toxicity and morphological alterations in cardiac myocytes. International Journal of Molecular Sciences, 23(3), p. 1401. ISSN (print) 1661-6596
Bruno, Lucrezia, Karagil, Simge, Mahmood, Almas, Elbediwy, Ahmed, Stolinski, Michael and Mackenzie, Francesca (2021) Mechanosensing and the Hippo pathway in microglia : a potential link to Alzheimer’s disease pathogenesis. Cells, 10(11), p. 3144. ISSN (online) 2073-4409
Cobbaut, Mathias, Karagil, Simge, Bruno, Lucrezia, de Loza, Maria Del Carmen Diaz, Mackenzie, Francesca E, Stolinski, Michael and Elbediwy, Ahmed (2020) Dysfunctional mechanotransduction through the YAP/TAZ/Hippo pathway as a feature of chronic disease. Cells, 9(1), p. 151. ISSN (online) 2073-4409
Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A., South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M., Kanuga, Naheed, Mackenzie, Francesca E., Dubis, Adam M., Georgiadis, Anastasios, Graca, Anna B., Pearson, Rachael A., Ali, Robin R., Sakami, Sanae, Palczewski, Krysztof, Sherman, Michael Y., Reeves, Philip J. and Cheetham, Michael E. (2017) Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics, 26(2), pp. 305-319. ISSN (print) 0964-6906
Cattin, Anne-Laure, Burden, Jemima J., Van Emmenis, Lucie, Mackenzie, Francesca E., Hoving, Julian J.A., Garcia Calavia, Noelia, Guo, Yanping, McLaughlin, Maeve, Rosenberg, Laura H., Quereda, Victor, Jamecna, Denisa, Napoli, Ilaria, Parrinello, Simona, Enver, Tariq, Ruhrberg, Christiana and Lloyd, Alison C. (2015) Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves. Cell, 162(5), pp. 1127-1139. ISSN (print) 0092-8674
Wiszniak, S, Mackenzie, FF, Anderson, P, Kabbara, S, Ruhrberg, C and Schwarz, Q (2015) Neural crest cell-derived VEGF promotes embryonic jaw extension. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(19), pp. 6086-6091. ISSN (online) 0027-8424
Tillo, Miguel, Ruhrberg, Christiana and Mackenzie, Francesca (2012) Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity. Cell Adhesion & Migration, 6(6), pp. 541-546. ISSN (print) 1933-6918
Mackenzie, Francesca, Morgan, Anna, Stolinski, Michael, Baker, Amanda, Reid, Dwain, Mador, Martha and Page, Nigel (2021) Supporting activities to embed creativity and innovation as an implicit part of the bioscience student experience. In: Horizons in STEM Higher Education Conference: Making Connections, Innovating and Sharing Pedagogy; 29-30 Jun 2021, The Open University, U.K. (Held online). (Unpublished)
Mikailionyte, Agne, Pierscionek, Barbara, Mackenzie, Francesca E and Augousti, Andy (2021) The effect of video-game visual training on visual function in adults with self–reported reading difficulties. In: Applied Vision Association Virtual Spring Meeting (2021); 29 Mar 2021, Held Online. (Unpublished)