Dr Jean-Marie Peron

About

In 2021, I completed my PhD in medicinal chemistry under Prof. R C. Hider, King's College London. After a few short research assignments, in 2002 I joined Prof. Keith Jones' group at Kingston University as a research fellow. During that time, I worked on semi-synthetic cardioactive steroids (bufadienolides); on a project funded by the Special Trustees of St Thomas' Hospital. In 2006, I changed direction and took on the role of NMR senior technician at Kingston, supporting teaching and research in the School of LSPC. During that time I collaborated with a number of academic colleagues offering NMR expertise to help answer varied scientific questions. In December 2017, I returned to the Department of Chemical and Pharmaceutical Sciences as lecturer in organic and pharmaceutical chemistry. I am now senior lecturer, and since June 2023 I have been the course leader for the undergraduate Chemistry programme.

Academic responsibilities

Senior Lecturer in Organic and Pharmaceutical Chemistry

Qualifications

  • D.U.T. de Chimie: I.U.T. de Chimie, Université de Rennes 1, France, 1993
  • BSc (Hons.) Chemistry: Kingston University, UK, 1995
  • PhD Medicinal Chemistry: King's College London, UK, 2002
  • Fellowship of the Higher Education Academy (FHEA), 2019

Teaching and learning

Senior Lecturer:

I teach chemistry on a number of courses. Although my role is to teach organic and pharmaceutical chemistry at levels 4-7, I also teach general chemistry to level 4 life sciences students (LS4002) and NMR and spectroscopy data analysis and interpretation to level 5 pharmaceutical science students (CH5007). I lead two modules: CH4005 - Foundation Chemistry and CH7070 - Design, Discovery and Development of Pharmaceuticals. I am involved in supervising a 1 MPharm, 7 MSc and 4 BSc projects during the academic year. I also am the personal tutor for up to 24 students in the Department of Chemical and Pharmaceutical Sciences.

Course Leader for Chemistry (June 2023 - current):

I am the Course Leader for the undergraduate Chemistry programmes (F100, F123). My experience as Admissions Tutor has given me clear insights into the recruitment processes for the two interlinked courses. This will inform my role as Chemistry CL, as we move forward and implement changes, such as embedding KU's Future Skills scheme, in the chemistry course.

Admissions Tutor for Chemistry and Pharmaceutical Science (Sept. 2020 - June 2023):

I was responsible for reviewing a number of applications to undergraduate courses in Chemistry and Pharmaceutical Sciences, working in close collaboration with the Faculty Admissions Team and the Faculty Recruitment Team. A key aspect of my role involved facilitating clearing and admissions activities in the Department of Chemical and Pharmaceutical Sciences and ensuring academic colleagues were equipped for clearing.

Qualifications and expertise

  • Fellow of the Higher Education Academy (FHEA)

Undergraduate courses taught

Postgraduate courses taught

Research

My current research interests include the structure elucidation of naturally occurring bioactive compounds (RMM<800DA) using high-resolution FT-NMR spectroscopy, and organic synthesis to prepare molecules with medicinal properties. I also collaborate on a number of projects where solution phase NMR is used as a means to quantify drugs (e.g. in formulation studies), their metabolites or investigate drug stability (e.g. anticancer drug cocktails). My interest is not limited to organic-type chemistry, I am also keen to collaborate on materials chemistry projects. I currently supervise and co-supervise PhD and MRes students in three different fields: NMR research, cancer research and chemical synthesis of metal chelators for sensing.

Up-to-date publication list available here: https://bit.ly/4a87p8o (MS Word Document).

Areas of specialism

  • Synthetic Organic Chemistry
  • Natural Products Structure Elucidation
  • Bruker Avance III NMR Spectrometer Automation and Topspin 3+ AU Programming
  • NMR Data Processing and Interpretation

Research student supervision

Main supervision

Other supervision

Publications

Number of items: 24.

Article

Durrant, Arija, Peron, Jean-Marie R., Langat, Moses K., Robertson, Cameron and Le Gresley, Adam (2024) Modified PSYCHE NMR - the possibility for the direct semi-quantitation of components in mixtures. Talanta, 268(1), p. 125332. ISSN (print) 0039-9140

Peron, Jean-Marie R., Packman, Hollie, Peveler, William J. and Bear, Joseph C. (2020) In situ formation of low molecular weight organogelators for slick solidification. RSC Advances, 10(23), pp. 13369-13373. ISSN (online) 2046-2069

Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean-Marie, Robinson, Joshua and O'Leary, Shane (2019) Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil. Journal of Analytical and Applied Pyrolysis, 140, pp. 281-289. ISSN (print) 0165-2370

Babenko, Mai, Peron, Jean-Marie R., Kaialy, Waseem, Calabrese, Gianpiero, Alany, Raid G. and ElShaer, Amr (2019) [sup]1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations. International Journal of Pharmaceutics, 564, pp. 318-328. ISSN (print) 0378-5173

Le Gresley, Adam and Peron, Jean-Marie R. (2019) A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis. Food Chemistry, 275, pp. 385-389. ISSN (print) 0308-8146

Salman, D, Peron, J-M R, Goronga, T, Barton, S, Swinden, J and Nabhani-Gebara, Shereen (2016) HPLC & NMR-based forced degradation studies of ifosfamide: The potential of NMR in stability studies. Annales Pharmaceutiques Francaises, 74(2), pp. 119-128. ISSN (print) 0003-4509

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie and Nabhani-Gebara, Shereen (2016) Evaluation of the stability profile of anticancer drugs: a review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma. Journal of Oncology Pharmacy Practice, 22(1), pp. 86-91. ISSN (print) 1078-1552

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie R., Barton, Stephen and Nabhani-Gebara, Shereen (2016) New investigations into the stability of Mesna using LC-MS/MS and NMR. Expert review of anticancer therapy, 16(1), pp. 123-130. ISSN (print) 1473-7140

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie R. and Nabhani-Gebara, Shereen (2014) Improving drug stability to promote home cancer therapy. Hospital Pharmacy Europe(72), pp. 38-40.

Hilton, Philip, McKinnon, William, Gravett, Edward, Peron, Jean-Marie, Frampton, Christopher M, Nicholls, M Gary and Lord, Gwyn (2010) Selective inhibition of the cellular sodium pump by emicymarin and 14ss anhydroxy bufadienolides. Steroids, 75(13-14), pp. 1137-1145. ISSN (print) 0039-128X

McKinnon, William, Pentecost, C, Lord, Gwyn A, Forni, Lui G, Peron, Jean-Marie and Hilton, Philip J (2008) Elevation of anions in exercise-induced acidosis: a study by ion-exchange chromatography/mass spectrometry. Biomedical Chromatography, 22(3), pp. 301-305. ISSN (print) 0269-3879

Hilton, P.J., McKinnon, W., Lord, G.A., Peron, J.-M.R. and Forni, L.G. (2006) Unexplained acidosis of malnutrition: a study by ion-exchange chromatography/mass spectrometry. Biomedical Chromatography, 20(12), pp. 1386-1389. ISSN (print) 0269-3879

McKinnon, William, Lord, Gwyn A, Forni, Lui G, Peron, Jean-Marie R and Hilton, Philip J (2006) A rapid LC-MS method for determination of plasma anion profiles of acidotic patients. Journal of Chromatography B, 833(2), pp. 179-185. ISSN (print) 1570-0232

Rossiter, Sharon, Peron, Jean-Marie, Whitfield, Philip J. and Jones, Keith (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorganic & Medicinal Chemistry Letters, 15(21), pp. 4806-4808. ISSN (print) 0960-894X

Forni, Lui G, McKinnon, William, Lord, Gwyn A, Treacher, David F, Peron, Jean-Marie R and Hilton, Philip J (2005) Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis. Critical Care (Online), 9(5), R591-R595. ISSN (online) 1466-609X

Hilton, Philip J., McKinnon, W., Jones, Keith, Peron, Jean-Marie, Gravett, Edward C. and Lord, Gwyn A (2005) P-440: Differential inhibition of Na-K ATPases by synthetic 14 [beta] bufadienolides. American Journal of Hypertension, 18(5), 166A-166A. ISSN (print) 0895-7061

Gravett, Edward C., Hilton, Philip J, Jones, Keith and Peron, Jean-Marie (2003) A new route to 5-aryl and 5-heteroaryl-2-pyrones via Suzuki coupling of a 2-pyrone-5-boronate ester. Synlett, 2, 0253-0255. ISSN (print) 0936-5214

Conference or Workshop Item

Durrant, Arija, Peron, Jean-Marie, Le Gresley, Adam and Langat, Moses (2022) Identification and quantification of isolated medicinal compounds by PSYCHE NMR and DOSY NMR. In: Ampere NMR School 2022; 19-25 Jun 2022, Zakopane, Poland. (Unpublished)

Salman, Dahlia, Barton, Stephen, Swinden, Julian, Peron, Jean-Marie, Wertheim, David, Kayyali, Reem and Nabhani-Gebara, Shereen (2015) Ambulatory chemotherapy: the bench to bedside. In: Quality Improvement in Chemotherapy Commissioning Meeting; 10 Feb 2015, London, U.K.. (Unpublished)

Salman, D., Peron, J.M., Goronga, T., Swinden, J., Barton, S. and Nabhani-Gebara, S. (2014) The potential of NMR in oncology pharmacy: a forced degradation study of Ifosfamide. In: UKPharmasci APS Conference 2014; 10-12 Sep 2014, Hatfield, U.K..

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie and Nabhani-Gebara, Shereen (2014) Evaluation of the stability of Ifosfamide and Mesna in elastomeric pumps : bench to bedside. In: XIV International Symposium on Oncology Pharmacy Practice (ISOPP XIV) : Building Partnerships in Care; 02 - 05 Apr 2014, Montreal, Canada. (Unpublished)

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie, Barton, Stephen and Nabhani-Gebara, Shereen (2013) Evaluation of the solubility and stability of ifosfamide in order to answer practice based challenges. In: 16th Annual BOPA Symposium; 18 - 20 Oct 2013, Edinburgh, U.K.. (Unpublished)

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie, Barton, Stephen and Nabhani-Gebara, Shereen (2013) Optimising home chemotherapy through analytical research : the physicochemical stability of Mesna using LC-MS/MS and NMR. In: UKPharmasci APS Conference 2013; 02 - 04 Sep 2013, Edinburgh, U.K.. (Unpublished)

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)

This list was generated on Mon Jul 15 07:55:54 2024 BST.

Professional practice, knowledge exchange and impact

Sept. 2023 - current: Member of the RSC Directors of Undergraduate Teaching policy group.

Professional and scholarly affiliations

  • Member of the Royal Society of Chemistry (MRSC), 2014
  • Fellowship of the Higher Education Academy (FHEA), 2019

Social media

LinkedIn