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Dr Jean-Marie Peron

Lecturer in Organic and Pharmaceutical Chemistry

About

I trained as an organic/medicinal chemist and strayed into the NMR field (pun intended) as a result of my research. The projects I have worked on have revolved around synthetic organic chemistry. I have synthesised drug-like compounds, worked on plant extracts and analysed organics and complexes using chiefly NMR spectroscopy to characterise those compounds. Working in collaboration with other scientists, I have cultivated my knowledge of NMR and how the technology can be used to answer varied scientific questions. My main research interests lie in drugs of natural origin, organic synthesis, and the use of NMR to answer a range of questions, such as identifying a compound, determining potency or investigating drug stability.

Areas of specialism

  • Drugs of natural sources
  • FT-NMR spectroscopy (solution phase)
  • Medicinal chemistry
  • Organic chemistry
  • Structure elucidation

Qualifications

  • 1997 - 2001: PhD Medicinal Chemistry - King's College London, London, UK
  • 1993 - 1995: BSc (Hons) Chemistry - Kingston University, Kingston Upon Thames, UK
  • 1991 - 1993: D.U.T. de Chimie - I.U.T. de Chimie, Université de Rennes, France

Professional membership

2014 - present: Member of the Royal Society of Chemistry

Research

My current research interests include the structure elucidation of naturally occurring bioactive compounds (RMM<800DA) using high-resolution FT-NMR spectroscopy, and organic synthesis to prepare molecules with medicinal properties. I have also collaborated on a number of projects where solution phase NMR was used as a means to quantify drugs (e.g. in formulation studies) or investigate drug stability (e.g. anticancer drug cocktails).

Publications

Number of items: 16.

Article

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie and Nabhani-Gebara, Shereen (2016) Evaluation of the stability profile of anticancer drugs: a review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma. Journal of Oncology Pharmacy Practice, 22(1), pp. 86-91. ISSN (print) 1078-1552

Salman, D, Peron, J-M R, Goronga, T, Barton, S, Swinden, J and Nabhani-Gebara, Shereen (2016) HPLC & NMR-based forced degradation studies of ifosfamide: The potential of NMR in stability studies. Annales Pharmaceutiques Francaises, 74(2), pp. 119-128. ISSN (print) 0003-4509

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie R., Barton, Stephen and Nabhani-Gebara, Shereen (2016) New investigations into the stability of Mesna using LC-MS/MS and NMR. Expert review of anticancer therapy, 16(1), pp. 123-130. ISSN (print) 1473-7140

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie R. and Nabhani-Gebara, Shereen (2014) Improving drug stability to promote home cancer therapy. Hospital Pharmacy Europe(72), pp. 38-40.

Hilton, Philip, McKinnon, William, Gravett, Edward, Peron, Jean-Marie, Frampton, Christopher M, Nicholls, M Gary and Lord, Gwyn (2010) Selective inhibition of the cellular sodium pump by emicymarin and 14ss anhydroxy bufadienolides. Steroids, 75(13-14), pp. 1137-1145. ISSN (print) 0039-128X

McKinnon, William, Pentecost, C, Lord, Gwyn A, Forni, Lui G, Peron, Jean-Marie and Hilton, Philip J (2008) Elevation of anions in exercise-induced acidosis: a study by ion-exchange chromatography/mass spectrometry. Biomedical Chromatography, 22(3), pp. 301-305. ISSN (print) 0269-3879

Hilton, P.J., McKinnon, W., Lord, G.A., Peron, J.-M.R. and Forni, L.G. (2006) Unexplained acidosis of malnutrition: a study by ion-exchange chromatography/mass spectrometry. Biomedical Chromatography, 20(12), pp. 1386-1389. ISSN (print) 0269-3879

McKinnon, William, Lord, Gwyn A, Forni, Lui G, Peron, Jean-Marie R and Hilton, Philip J (2006) A rapid LC-MS method for determination of plasma anion profiles of acidotic patients. Journal of Chromatography B, 833(2), pp. 179-185. ISSN (print) 1570-0232

Forni, Lui G, McKinnon, William, Lord, Gwyn A, Treacher, David F, Peron, Jean-Marie R and Hilton, Philip J (2005) Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis. Critical Care (Online), 9(5), R591-R595. ISSN (online) 1466-609X

Hilton, Philip J., McKinnon, W., Jones, Keith, Peron, Jean-Marie, Gravett, Edward C. and Lord, Gwyn A (2005) P-440: Differential inhibition of Na-K ATPases by synthetic 14 [beta] bufadienolides. American Journal of Hypertension, 18(5), 166A-166A. ISSN (print) 0895-7061

Rossiter, Sharon, Peron, Jean-Marie, Whitfield, Philip J. and Jones, Keith (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorganic & Medicinal Chemistry Letters, 15(21), pp. 4806-4808. ISSN (print) 0960-894X

Gravett, Edward C., Hilton, Philip J, Jones, Keith and Peron, Jean-Marie (2003) A new route to 5-aryl and 5-heteroaryl-2-pyrones via Suzuki coupling of a 2-pyrone-5-boronate ester. Synlett, 2, 0253-0255. ISSN (print) 0936-5214

Conference or Workshop Item

Salman, Dahlia, Barton, Stephen, Swinden, Julian, Peron, Jean-Marie, Wertheim, David, Kayyali, Reem and Nabhani-Gebara, Shereen (2015) Ambulatory chemotherapy: the bench to bedside. In: Quality Improvement in Chemotherapy Commissioning Meeting; 10 Feb 2015, London, U.K.. (Unpublished)

Salman, D., Peron, J.M., Goronga, T., Swinden, J., Barton, S. and Nabhani-Gebara, S. (2014) The potential of NMR in oncology pharmacy: a forced degradation study of Ifosfamide. In: UKPharmasci APS Conference 2014; 10-12 Sep 2014, Hatfield, U.K..

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie, Barton, Stephen and Nabhani-Gebara, Shereen (2013) Evaluation of the solubility and stability of ifosfamide in order to answer practice based challenges. In: 16th Annual BOPA Symposium; 18 - 20 Oct 2013, Edinburgh, U.K.. (Unpublished)

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)

This list was generated on Mon Jul 23 04:25:52 2018 BST.
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