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Dr Jean-Marie Peron

Lecturer in Organic and Pharmaceutical Chemistry

About

I completed my PhD in medicinal chemistry in 2001 at King's College London and after a few short research assignments, I joined Kingston University as a research fellow in 2002. I worked on semi-synthetic cardioactive steroids (bufadienolides), a project funded by the Special Trustees of St Thomas' Hospital. In 2006, I changed direction and took on the role of NMR senior technician at Kingston, supporting teaching and research in the School of LSPC. During that time I collaborated with a number of academic colleagues offering NMR expertise to help answer varied scientific questions. In December 2017, I returned to the Department of Chemical and Pharmaceutical Sciences as lecturer in organic and pharmaceutical chemistry.

Areas of specialism

  • Medicinal chemistry
  • Organic chemistry
  • FT-NMR spectroscopy (solution phase)
  • Structure elucidation
  • NMR data processing (TopSpin 3 & 4, SpinWorks 3 & 4)

Qualifications

  • PhD Medicinal Chemistry - King's College London, London, UK
  • BSc (Hons.) Chemistry - Kingston University, Kingston Upon Thames, UK
  • D.U.T. de Chimie - I.U.T. de Chimie, Université de Rennes, France

Professional membership

2014 - present: Member of the Royal Society of Chemistry (MRSC)

Research

My current research interests include the structure elucidation of naturally occurring bioactive compounds (RMM<800DA) using high-resolution FT-NMR spectroscopy, and organic synthesis to prepare molecules with medicinal properties. I also collaborate on a number of projects where solution phase NMR is used as a means to quantify drugs (e.g. in formulation studies) or investigate drug stability (e.g. anticancer drug cocktails).

Research student supervision

Publications

Number of items: 20.

Article

Babenko, Mai, Peron, Jean-Marie R., Kaialy, Waseem, Calabrese, Gianpiero, Alany, Raid G. and ElShaer, Amr (2019) [sup]1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations. International Journal of Pharmaceutics, 564, pp. 318-328. ISSN (print) 0378-5173

Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean-Marie, Robinson, Joshua and O'Leary, Shane (2019) Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil. Journal of Analytical and Applied Pyrolysis, ISSN (print) 0165-2370 (Epub Ahead of Print)

Le Gresley, Adam and Peron, Jean-Marie R. (2019) A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis. Food Chemistry, 275, pp. 385-389. ISSN (print) 0308-8146

Salman, D, Peron, J-M R, Goronga, T, Barton, S, Swinden, J and Nabhani-Gebara, Shereen (2016) HPLC & NMR-based forced degradation studies of ifosfamide: The potential of NMR in stability studies. Annales Pharmaceutiques Francaises, 74(2), pp. 119-128. ISSN (print) 0003-4509

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie and Nabhani-Gebara, Shereen (2016) Evaluation of the stability profile of anticancer drugs: a review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma. Journal of Oncology Pharmacy Practice, 22(1), pp. 86-91. ISSN (print) 1078-1552

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie R., Barton, Stephen and Nabhani-Gebara, Shereen (2016) New investigations into the stability of Mesna using LC-MS/MS and NMR. Expert review of anticancer therapy, 16(1), pp. 123-130. ISSN (print) 1473-7140

Salman, Dahlia, Swinden, Julian, Barton, Stephen, Peron, Jean-Marie R. and Nabhani-Gebara, Shereen (2014) Improving drug stability to promote home cancer therapy. Hospital Pharmacy Europe(72), pp. 38-40.

Hilton, Philip, McKinnon, William, Gravett, Edward, Peron, Jean-Marie, Frampton, Christopher M, Nicholls, M Gary and Lord, Gwyn (2010) Selective inhibition of the cellular sodium pump by emicymarin and 14ss anhydroxy bufadienolides. Steroids, 75(13-14), pp. 1137-1145. ISSN (print) 0039-128X

McKinnon, William, Pentecost, C, Lord, Gwyn A, Forni, Lui G, Peron, Jean-Marie and Hilton, Philip J (2008) Elevation of anions in exercise-induced acidosis: a study by ion-exchange chromatography/mass spectrometry. Biomedical Chromatography, 22(3), pp. 301-305. ISSN (print) 0269-3879

Hilton, P.J., McKinnon, W., Lord, G.A., Peron, J.-M.R. and Forni, L.G. (2006) Unexplained acidosis of malnutrition: a study by ion-exchange chromatography/mass spectrometry. Biomedical Chromatography, 20(12), pp. 1386-1389. ISSN (print) 0269-3879

McKinnon, William, Lord, Gwyn A, Forni, Lui G, Peron, Jean-Marie R and Hilton, Philip J (2006) A rapid LC-MS method for determination of plasma anion profiles of acidotic patients. Journal of Chromatography B, 833(2), pp. 179-185. ISSN (print) 1570-0232

Rossiter, Sharon, Peron, Jean-Marie, Whitfield, Philip J. and Jones, Keith (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorganic & Medicinal Chemistry Letters, 15(21), pp. 4806-4808. ISSN (print) 0960-894X

Forni, Lui G, McKinnon, William, Lord, Gwyn A, Treacher, David F, Peron, Jean-Marie R and Hilton, Philip J (2005) Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis. Critical Care (Online), 9(5), R591-R595. ISSN (online) 1466-609X

Hilton, Philip J., McKinnon, W., Jones, Keith, Peron, Jean-Marie, Gravett, Edward C. and Lord, Gwyn A (2005) P-440: Differential inhibition of Na-K ATPases by synthetic 14 [beta] bufadienolides. American Journal of Hypertension, 18(5), 166A-166A. ISSN (print) 0895-7061

Gravett, Edward C., Hilton, Philip J, Jones, Keith and Peron, Jean-Marie (2003) A new route to 5-aryl and 5-heteroaryl-2-pyrones via Suzuki coupling of a 2-pyrone-5-boronate ester. Synlett, 2, 0253-0255. ISSN (print) 0936-5214

Conference or Workshop Item

Salman, Dahlia, Barton, Stephen, Swinden, Julian, Peron, Jean-Marie, Wertheim, David, Kayyali, Reem and Nabhani-Gebara, Shereen (2015) Ambulatory chemotherapy: the bench to bedside. In: Quality Improvement in Chemotherapy Commissioning Meeting; 10 Feb 2015, London, U.K.. (Unpublished)

Salman, D., Peron, J.M., Goronga, T., Swinden, J., Barton, S. and Nabhani-Gebara, S. (2014) The potential of NMR in oncology pharmacy: a forced degradation study of Ifosfamide. In: UKPharmasci APS Conference 2014; 10-12 Sep 2014, Hatfield, U.K..

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie, Barton, Stephen and Nabhani-Gebara, Shereen (2013) Evaluation of the solubility and stability of ifosfamide in order to answer practice based challenges. In: 16th Annual BOPA Symposium; 18 - 20 Oct 2013, Edinburgh, U.K.. (Unpublished)

Salman, Dahlia, Swinden, Julian, Peron, Jean-Marie, Barton, Stephen and Nabhani-Gebara, Shereen (2013) Optimising home chemotherapy through analytical research : the physicochemical stability of Mesna using LC-MS/MS and NMR. In: UKPharmasci APS Conference 2013; 02 - 04 Sep 2013, Edinburgh, U.K.. (Unpublished)

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)

This list was generated on Mon Sep 23 04:56:45 2019 BST.
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