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Dr. Francesca Arrigoni is a Senior Lecturer at Kingston in the Department of Pharmacy at Kingston (ranked #1 in London, and top 10 in the UK for Pharmacy) and has close ties working with the Infection, Immunity and Rheumatology at GOSH, the institute of Child Health, UCL which is based in the Faculty of Population Health Sciences #12 globally for Clinical, Pre-clinical & Health and in Life Sciences. Prior to that, she gained her PhD and post-doctoral experience at UCL and completed her undergraduate degree at Glasgow University with several awards and distinctions (John Hunter Medal 2 consecutive years).
Since joining Kingston University, and completing my Post-Graduate Certificate in Education I have been shortlisted for the Times Higher Education Teaching excellence award - Outstanding Research Supervisor of the year 2017 and have been awarded a Senior Fellowship of the Higher Education Academy in 2018.
I have a small research group, which as a result of a successful collaboration with UCL, aims to understand how chronic inflammation and the activation of your immune system can influence the health of your vasculature with diseases, that include HIV and also vasculitis with numerous publications in the field of endothelial and vascular physiology.
Senior lecturer Physiology/Pharmacology
My research interests are focused upon the interaction of the vascular endothelium with various leukocyte populations under settings of vascular dysfunction and inflammatory stress.
I have developed an increasing interest in the interactions of monocytes with the vascular endothelium and have been awarded grant funding to investigate the influence of nitric oxide on monocytic motility. My current research projects investigate the role of infection in vascular disease, focussing on HIV and autoimmune and inflammatory diseases in children. These projects benefit from active and productive collaborations at the GOSH, Institute of Child Health, UCL.
I am also currently on the team for the analysis of data for the ARROW, EARNEST and CHAPAS HIV trials, carried out at GOSH, Institute of Child Health, UCL.
Kelly, Christine, Tinago, Willard, Alber, Dagmar, Hunter, Patricia, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Abner, Alejandro Garcia, Kamngona, Ralph, Sheha, Irene, Chammudzi, Mishek, Jambo, Kondwani, Mallewa, Jane, Rapala, Alicja, Heyderman, Robert S, Mallon, Patrick WG, Mwandumba, Henry, Walker, A. Sarah, Klein, Nigel and Khoo, Saye (2020) Inflammatory phenotypes predict changes in arterial stiffness following ART initiation. Clinical Infectious Diseases, ciaa186. ISSN (print) 1058-4838 (Epub Ahead of Print)
Ghosh, Anshuman, Freestone, Nicholas S, Anim-Nyame, Nicholas and Arrigoni, Francesca I F (2017) Microvascular function in pre-eclampsia is influenced by insulin resistance and an imbalance of angiogenic mediators. Physiological Reports, 5(8), e13185. ISSN (online) 2051-817X
Lambden, Simon, Kelly, Peter, Ahmetaj-Shala, Blerina, Wang, Zhen, Lee, Benjamin, Nandi, Manasi, Torondel, Belen, Delahaye, Matthew, Dowsett, Laura, Piper, Sophie, Tomlinson, James, Caplin, Ben, Colman, Lucy, Boruc, Olga, Slaviero, Anna, Zhao, Lan, Oliver, Eduardo, Khadayate, Sanjay, Singer, Mervyn, Arrigoni, Francesca and Leiper, James (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. ISSN (print) 1079-5642
Anim-Nyame, Nick, Ghosh, Anshuman, Freestone, Nicholas and Arrigoni, Francesca (2015) Relationship between insulin resistance and circulating endothelial cells in pre-eclampsia. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), pp. 788-791. ISSN (print) 1473-0766
Fabbri-Arrigoni, Francesca I., Clarke, Lindsey, Wang, Guosu, Charakida, Marietta, Ellins, Elizabeth, Halliday, Neil, Brogan, Paul A., Deanfield, John E., Halcox, Julian P. and Klein, Nigel (2012) Levels of circulating endothelial cells and colony forming units are influenced by age and dyslipidaemia. Pediatric Research, 72(3), pp. 299-304. ISSN (print) 0031-3998
Arrigoni, Francesca I, Matarin, Mar, Thompson, Pamela J, Michaelides, Michel, McClements, Michelle E, Redmond, Elizabeth, Clarke, Lindsey, Ellins, Elizabeth, Mohamed, Saifullah, Pavord, Ian, Hunt, David M, Moore, Anthony T, Halcox, Julian and Sisodiya, Sanjay M (2011) Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy. European Journal of Human Genetics, 19(2), pp. 131-137. ISSN (print) 1018-4813
Arrigoni, Francesca, Ahmetaj, Blerina and Leiper, James (2010) The biology and therapeutic potential of the DDAH/ADMA pathway. Current Pharmaceutical Design, 16(37), pp. 4089-4102. ISSN (print) 1381-6128
Clarke, LA, Hong, Y, Eleftheriou, D, Shah, V, Arrigoni, Francesca, Klein, NJ and Brogan, PA (2010) Endothelial injury and repair in systemic vasculitis of the young. Arthritis & Rheumatism, 62(6), pp. 1770-1780. ISSN (print) 0004-3591
Abdullah, A, Arrigoni, F and Freestone, N (2010) Tumour cell adhesion of endothelial cell monolayer. Journal of Pharmacy and Pharmacology, 62(10), pp. 1496-1498. ISSN (print) 0022-3573
Clarke, Lindsey, Shah, Vanita, Arrigoni, Francesca, Eleftheriou, D., Hong, Ying, Halcox, Julian, Klein, Nigel and Brogan, Paul (2008) Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction. Journal Of Thrombosis And Haemostasis, 6(6), pp. 1025-1032. ISSN (print) 1538-7933
Nandi, Manasi, Leiper, James, Arrigoni, Francesca, Hislop, Alison, Vallance, Patrick and Haywoth, Sheila (2006) Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation. Pediatric Research, 59(6), pp. 767-772. ISSN (print) 0031-3998
Smith, Caroline L., Birdsey, Graeme M., Anthony, Shelagh, Arrigoni, Francesca I., Leiper, James M. and Vallance, Patrick (2003) Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Biochemical and Biophysical Research Communications, 308(4), pp. 984-989. ISSN (print) 0006-291X
Arrigoni, Francesca I., Vallance, Patrick, Haworth, Sheila G. and Leiper, James M. (2003) Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation, 107(8), pp. 1195-1201. ISSN (print) 0009-7322
Achan, Vinod, Tran, Cam T.L., Arrigoni, Francesca, Whitley, Guy St.J., Leiper, James M. and Vallance, Patrick (2002) all-trans-retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase. Circulation Research, 90(7), pp. 764-769. ISSN (print) 0009-7330
Leiper, James, Arrigoni, Francesca and Ahmetaj, Blerina (2012) The Therapeutic Potential of Dimethylarginine Dimethylaminohydrolase–Mediated Regulation of Nitric Oxide Synthesis. In: Abraham, David , Handler, Clive , Dashwood, Michael and Coghlan, Gerry, (eds.) Translational Vascular Medicine. London, U.K. : Springer Verlag. pp. (II)61-(II)88. ISBN 9780857299192
Arrigoni, Francesca, Micallef, Ricarda and Wason, Hilary (2019) Embedding critical thinking skills in the scientific curricula : how good are we? In: Horizons in STEM Higher Education Conference : Making Connections and Sharing Pedagogy; 03 -04 Jul 2019, Kingston upon Thames, U.K.. (Unpublished)