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Dr Francesca Arrigoni

Senior lecturer Physiology/Pharmacology

About

Dr. Francesca Arrigoni  is a Senior Lecturer at Kingston in the Department of Pharmacy at Kingston (ranked #1 in London, and top 10 in the UK for Pharmacy) and has close ties working with the Infection, Immunity and Rheumatology at GOSH, the institute of Child Health, UCL which   is based in the Faculty of Population Health Sciences #12  globally for Clinical, Pre-clinical & Health and in Life Sciences. Prior to that, she gained her PhD and post-doctoral experience at UCL and completed her undergraduate degree at Glasgow University with several awards and distinctions (John Hunter Medal 2 consecutive years).

Since joining Kingston University, and completing my Post-Graduate Certificate in Education I have been shortlisted for the Times Higher Education Teaching excellence award - Outstanding Research Supervisor of the year 2017 and have been awarded a Senior Fellowship of the Higher Education Academy in 2018. 

I have a small research group, which  as a result of a successful collaboration with UCL, aims to understand how chronic inflammation and the activation of your immune system can influence the health of your vasculature with diseases, that include HIV and also vasculitis  with numerous publications in the field of endothelial and vascular physiology.

Areas of specialism

  • Vascular disease in inflammation
  • inflammation
  • Cardiovascular disease
  • endothelial dysfunction
  • Inflammatory Markers
  • Vascular
  • cardiovascular research
  • nitric oxide
  • endothelial cells
  • HIV

Qualifications

  • PhD Pharmacology UCL
  • BSc (Hons) Physiology Glasgow University
  • Senior Fellowship Higher Education Authority

Professional membership

Senior Fellow of the Higher Education Authority

Member of the Physiological Society since 2012

Member of the British Pharmacological Society  since 2015

Honorary Contract at Great Ormond Street, The Institute of Child Health,UCL. 

  • Other information

Advocating for others Francesca has enabled the introduction of university- wide policies to promote diversity and inclusion in Higher Education being a key contributor in attaining our Athena SWAN bronze award for the  department of Life Sciences Pharmacy and Chemistry, the first of its kind at Kingston  University.  Moreover, she is a role model for many younger women who see her as carving a niche for working parents and who champions, supports and mentors others.

Research

My research interests are focused upon the interaction of the vascular endothelium with various leukocyte populations under settings of vascular dysfunction and inflammatory stress.

I have developed an increasing interest in the interactions of monocytes with the vascular endothelium and have been awarded grant funding to investigate the influence of nitric oxide on monocytic motility. My current research projects investigate the role of infection in vascular disease, focussing on HIV and autoimmune and inflammatory diseases in children. These projects benefit from active and productive collaborations at the GOSH, Institute of Child Health, UCL. 

I am also currently on the team for the analysis of data for the ARROW, EARNEST and CHAPAS HIV trials, carried out at GOSH, Institute of Child Health, UCL. 

Publications

Number of items: 14.

Article

Ghosh, Anshuman, Freestone, Nicholas S, Anim-Nyame, Nicholas and Arrigoni, Francesca I F (2017) Microvascular function in pre-eclampsia is influenced by insulin resistance and an imbalance of angiogenic mediators. Physiological Reports, 5(8), e13185. ISSN (online) 2051-817X

Lambden, Simon, Kelly, Peter, Ahmetaj-Shala, Blerina, Wang, Zhen, Lee, Benjamin, Nandi, Manasi, Torondel, Belen, Delahaye, Matthew, Dowsett, Laura, Piper, Sophie, Tomlinson, James, Caplin, Ben, Colman, Lucy, Boruc, Olga, Slaviero, Anna, Zhao, Lan, Oliver, Eduardo, Khadayate, Sanjay, Singer, Mervyn, Arrigoni, Francesca and Leiper, James (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. ISSN (print) 1079-5642

Anim-Nyame, Nick, Ghosh, Anshuman, Freestone, Nicholas and Arrigoni, Francesca (2015) Relationship between insulin resistance and circulating endothelial cells in pre-eclampsia. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), pp. 788-791. ISSN (print) 1473-0766

Fabbri-Arrigoni, Francesca I., Clarke, Lindsey, Wang, Guosu, Charakida, Marietta, Ellins, Elizabeth, Halliday, Neil, Brogan, Paul A., Deanfield, John E., Halcox, Julian P. and Klein, Nigel (2012) Levels of circulating endothelial cells and colony forming units are influenced by age and dyslipidaemia. Pediatric Research, 72(3), pp. 299-304. ISSN (print) 0031-3998

Arrigoni, Francesca I, Matarin, Mar, Thompson, Pamela J, Michaelides, Michel, McClements, Michelle E, Redmond, Elizabeth, Clarke, Lindsey, Ellins, Elizabeth, Mohamed, Saifullah, Pavord, Ian, Hunt, David M, Moore, Anthony T, Halcox, Julian and Sisodiya, Sanjay M (2011) Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy. European Journal of Human Genetics, 19(2), pp. 131-137. ISSN (print) 1018-4813

Arrigoni, Francesca, Ahmetaj, Blerina and Leiper, James (2010) The biology and therapeutic potential of the DDAH/ADMA pathway. Current Pharmaceutical Design, 16(37), pp. 4089-4102. ISSN (print) 1381-6128

Clarke, LA, Hong, Y, Eleftheriou, D, Shah, V, Arrigoni, Francesca, Klein, NJ and Brogan, PA (2010) Endothelial injury and repair in systemic vasculitis of the young. Arthritis & Rheumatism, 62(6), pp. 1770-1780. ISSN (print) 0004-3591

Abdullah, A, Arrigoni, F and Freestone, N (2010) Tumour cell adhesion of endothelial cell monolayer. Journal of Pharmacy and Pharmacology, 62(10), pp. 1496-1498. ISSN (print) 0022-3573

Clarke, Lindsey, Shah, Vanita, Arrigoni, Francesca, Eleftheriou, D., Hong, Ying, Halcox, Julian, Klein, Nigel and Brogan, Paul (2008) Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction. Journal Of Thrombosis And Haemostasis, 6(6), pp. 1025-1032. ISSN (print) 1538-7933

Nandi, Manasi, Leiper, James, Arrigoni, Francesca, Hislop, Alison, Vallance, Patrick and Haywoth, Sheila (2006) Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation. Pediatric Research, 59(6), pp. 767-772. ISSN (print) 0031-3998

Smith, Caroline L., Birdsey, Graeme M., Anthony, Shelagh, Arrigoni, Francesca I., Leiper, James M. and Vallance, Patrick (2003) Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Biochemical and Biophysical Research Communications, 308(4), pp. 984-989. ISSN (print) 0006-291X

Arrigoni, Francesca I., Vallance, Patrick, Haworth, Sheila G. and Leiper, James M. (2003) Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation, 107(8), pp. 1195-1201. ISSN (print) 0009-7322

Achan, Vinod, Tran, Cam T.L., Arrigoni, Francesca, Whitley, Guy St.J., Leiper, James M. and Vallance, Patrick (2002) all-trans-retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase. Circulation Research, 90(7), pp. 764-769. ISSN (print) 0009-7330

Book Section

Leiper, James, Arrigoni, Francesca and Ahmetaj, Blerina (2012) The Therapeutic Potential of Dimethylarginine Dimethylaminohydrolase–Mediated Regulation of Nitric Oxide Synthesis. In: Abraham, David , Handler, Clive , Dashwood, Michael and Coghlan, Gerry, (eds.) Translational Vascular Medicine. London, U.K. : Springer Verlag. pp. (II)61-(II)88. ISBN 9780857299192

This list was generated on Mon Oct 21 05:07:40 2019 BST.
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