Dr Andrew Snabaitis
Faculties, departments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Pharmacy
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Associate Professor in Molecular Cardiology
- Email:
- [email protected]
About
I studied pharmacology at King's College London (University of London) where I completed a BSc (Hons) in pharmacology with toxicology. This course had a 12-month extramural component which I spent at Beecham's Pharmaceuticals (Harlow, Essex) and developed an interest in cardiovascular research.
Upon recommendation, I then joined the United and Medical Dental Schools (UMDS) in London as a research assistant with the view of embarking on several years of research and study towards a PhD in cardiovascular sciences. I was lucky enough to receive studentship funded by the British Heart Foundation and successfully completed my PhD in 1998.
Since obtaining my PhD, I spent 11 years as a post-doctoral research associate/fellow in the Division of Cardiovascular Research at King's College London. I was funded by several research grants obtained from the Dunhill Medical Trust and the Medical Research Council.
My post-doctoral research career culminated in obtaining independent funding in the form of an Intermediate Research Fellowship from the British Heart Foundation, after which I joined Kingston University as a lecturer in pharmacology and physiology.
Since arriving at Kingston University, I have continued my research into heart disease which has been funded by the British Heart Foundation. My laboratory studies the role of type 2A serine/threonine protein phosphatase enzymes and their associated regulatory proteins at the cellular/molecular level in acute (ischaemia/reperfusion) and chronic (pressure overload) models of heart failure.
Qualifications
- PhD in Pharmacology from King's College London
- BSc Pharmacology with toxicology (2:1) from King's College London
Domains
Cardiac cellular and molecular biology has been my main research interest for many years, with a focus on the regulation of intracellular pH in adult ventricular cardiac cells. More recently, I have developed an interest in the role(s) of the serine/threonine type 2A protein phosphatases and their associated regulatory proteins in laboratory models of acute (ischaemia/reperfusion injury) and chronic (pressure overload-induced hypertrophy) heart failure.
Publications
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection
Paulsson-Habegger, Lukas, Snabaitis, Andrew K. and Wren, Stephen P., 2021, (48), pp 116389
Regulation of cardiomyocyte DNA damage and cell death by the type 2A protein phosphatase regulatory protein alpha4
Cowan, Jonathan, Longman, Michael R. and Snabaitis, Andrew K., 2021, Scientific Reports (11), pp 6293
Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy
Eleftheriadou, Olga, Boguslavskyi, Andrii, Longman, Michael R., Cowan, Jonathan, Francois, Asvi, Heads, Richard J., Wadzinski, Brian E., Ryan, Ali, Shattock, Michael J. and Snabaitis, Andrew K., 2017, Basic Research in Cardiology (112), 37, pp 1-18
The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of Factor H binding protein of ' Neisseria meningitidis ' strain MC58 and its potential as a drug target
da Silva, RAG, Churchward, CP, Karlyshev, AV, Eleftheriadou, O, Snabaitis, AK, Longman, MR, Ryan, A and Griffin, R, 2017, British Journal of Pharmacology (174), 14, pp 2247-2260
Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory Class G-Protein coupled receptors in cardiomyocytes
Longman, Michael R., Ranieri, Antonella, Avkiran, Metin and Snabaitis, Andrew K., 2014, PloS one (9), 1, pp e86234
Ca2+/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na+/H+ exchanger activation
Vila-Petroff, Martín, Mundiña-Weilenmann, Cecilia, Lezcano, Noelia, Snabaitis, Andrew K, Huergo, María Ana, Valverde, Carlos A., Avkiran, Metin and Mattiazzi, Alicia, 2010, Journal of Molecular and Cellular Cardiology (49), 1, pp 106-112
Urotensin II activates Sarcolemmal Na+/H+ exchanger in adult rat ventricular Myocytes
Kato, Koji, Yasutake, Masahiro, Dalin, Jia, Snabaitis, Andrew K, Avkiran, Metin, Kusama, Yoshiki, Takano, Teruo and Mizuno, Kyoichi, 2010, Journal of Cardiovascular Pharmacology (55), 2, pp 191-197
Protein Kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1
Snabaitis, Andrew K., Cuello, Friederike and Avkiran, Metin, 2008, Circulation Research (103), 8, pp 881-890
Expression of type 2A protein phosphatases in cardiac health and disease
Eleftheriadou, Olga, Boguslavskyi, Andrii, Ryan, Ali, Shattock, Michael J, Wadzinski, Brian E and Snabaitis, Andrew K(2015). In: 33rd Meeting of the International Society for Heart Research-European Section, 01 - 04 Jul 2015 :Bordeaux, France
Expression of type 2A protein phosphatases in cardiac health and disease
Eleftheriadou, O, Longman, MR, Boguslavskyi, A, Ryan, A, Wadzinski, BE, Shattock, MJ and Snabaitis, AK(2014). In: 2014 Autmun Meeting British Society for Cardiovascular Research, 08 - 09 Sep 2014 :Reading, U.K.