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Professor Fawaz Aldabbagh

Chair of Medicinal / Pharmaceutical Chemistry

About

I gained my BSc in Chemistry from Brunel University in 1994 and PhD in Organic Chemistry from Loughborough University in 1997. After completing two year postdoctoral fellowship at Griffith University in Brisbane, Australia, I gained my first academic position at the National University of Ireland Galway (NUI Galway) in 2000 at the age of 28. At NUI Galway I was Lecturer then Senior Lecturer in Chemistry and for a time, Vice Dean for the College of Science (Research). In 2007, I was Canon Foundation Research Fellow at Kobe University in Japan, and I have held Visiting Professorships at the Universities of Reims Champagne-Ardenne and Le Havre  (France) in 2013 and 2014. I am Fellow of the Royal Society of Chemistry (FRSC, UK) since 2009. I joined Kingston University on 1 September 2017 as Professor of Medicinal & Pharmaceutical Chemistry, after 17.5 years at NUI Galway.

Areas of specialism

  • Drug discovery and cancer research
  • Synthesis and heterocyclic chemistry
  • Polymer chemistry and smart materials
  • Green and radical chemistry

Qualifications

  • BSc (Hons)
  • PhD
  • FRSC

Professional membership

I am on the Editorial Board of Molecules (Basel, MDPI) and I have acted as Guest Editor for Special Issues: Free Radicals in Organic Synthesis (in 2016) and Recent Advances in Nitrogen-Containing Aromatic Heterocycles (in 2018). I am on the Editorial Board of Molbank (Basel, MDPI) 2018-2020: Organic Synthesis Section.   

I was the chair of Bioheterocycles 2017 at NUI Galway, and I am on the Scientific Committee of the International Conferences on Heterocycles in Bioorganic Chemistry, which are held biannually across Europe.

I have recently been appointed Section Editor for Comprehensive Heterocyclic Chemistry IV (Elsevier Ltd).

I have acted as external examiner at many universities in Australia, Cyprus, Ireland, and the UK, and I have given more than 60 invited and plenary lectures at conferences, universities and industrial companies throughout the world.  

I have been appointed Adjunct Professor at the National University of Ireland Galway (2017-2020).

Research

I lead a research group with interests in synthetic organic and polymer chemistry. In particular the discovery of small heterocyclic molecules for the treatment of cancer, and "smart" stimuli-responsive polymeric materials for drug delivery.

I have led pioneering work on the use of benign supercritical carbon dioxide for heterogeneous controlled / living radical polymerizations, and the use of environmentally friendly methods (including photochemical, visible light; hydrogen peroxide-HX) to synthesize complex small organic molecules. I maintain an interest in free radical reaction mechanisms from an organic, polymer and biochemical perspective.

I have supervised as PI, 22 PhDs to completion, and published 85 peer-reviewed research articles. Some recent publications are shown below.

I welcome talented research students and postdoctoral workers interested in my research both self-funded or interested in making funding applications to contact me with regards to joining my group. 

Research student supervision

Publications

Jump to: Article
Number of items: 21.

Article

Sweeney, Martin, McArdle, Patrick and Aldabbagh, Fawaz (2018) 1-Fluoro-2,5-dimethoxy-4-nitrobenzene. Molbank, 2018(1), M984. ISSN (online) 1422-8599

Keane, Lee-Ann J., Mirallai, Styliana I., Sweeney, Martin, Carty, Michael P., Zissimou, Georgia A., Berezin, Andrey A., Koutentis, Panayiotis A. and Aldabbagh, Fawaz (2018) Anti-cancer activity of phenyl and pyrid-2-yl 1,3-substituted benzo[1,2,4]triazin-7-ones and stable free radical precursors. Molecules, 23(3), p. 574. ISSN (online) 1420-3049

Duffy, Cormac, Zetterlund, Per B. and Aldabbagh, Fawaz (2018) Radical polymerization of alkyl 2-cyanoacrylates. Molecules, 23(2), p. 465. ISSN (online) 1420-3049

Kielty, Patrick, Smith, Dennis A., Cannon, Peter, Carty, Michael P., Kennedy, Michael, McArdle, Patrick, Singer, Richard J. and Aldabbagh, Fawaz (2018) Selective methylmagnesium chloride mediated acetylations of isosorbide : a route to powerful nitric oxide donor furoxans. Organic Letters, 20(10), pp. 3025-3029. ISSN (print) 1523-7060

Alzahrani, Abdullah, Mirallai, Styliana I., Chalmers, Benjamin A., McArdle, Patrick and Aldabbagh, Fawaz (2018) Synthesis of N-[(dialkylamino)methyl)]acrylamides and N-[(dialkylamino)methyl]methacrylamides from Schiff base salts : useful building blocks for smart polymers. Organic & Biomolecular Chemistry, ISSN (print) 1477-0520 (Epub Ahead of Print)

Chalmers, Benjamin A., Magee, Christopher, Cheung, David L., Zetterlund, Per B. and Al-Dabbagh, Fawaz (2017) CO[sub]2-responsive polyacrylamide copolymer vesicles with acid-sensitive morpholine moieties and large hydrophobic RAFT end-group. European Polymer Journal, 97, pp. 129-137. ISSN (print) 0014-3057

Chalmers, Benjamin A., Alzahrani, Abdullah, Hawkins, Gerard and Aldabbagh, Fawaz (2017) Efficient synthesis and RAFT polymerization of the previously elusive N -[(cycloalkylamino)methyl]acrylamide monomer class. Journal of Polymer Science Part A: Polymer Chemistry, 55(13), pp. 2123-2128. ISSN (print) 0887-624X

Sweeney, Martin, Gurry, Michael, Keane, Lee-Ann J. and Aldabbagh, Fawaz (2017) Greener synthesis using hydrogen peroxide in ethyl acetate of alicyclic ring-fused benzimidazoles and anti-tumour benzimidazolequinones. Tetrahedron Letters, 58(36), pp. 3565-3567. ISSN (print) 0040-4039

Duffy, Cormac, Phelan, Marisa, Zetterlund, Per B. and Aldabbagh, Fawaz (2017) Reversible addition-fragmentation chain transfer polymerization of alkyl-2-cyanoacrylates : an assessment of livingness. Journal of Polymer Science Part A: Polymer Chemistry, 55(8), pp. 1397-1408. ISSN (print) 0887-624X

Sweeney, Martin, Coyle, Robert, Kavanagh, Paul, Berezin, Andrey A., Lo Re, Daniele, Zissimou, Georgia A., Koutentis, Panayiotis A., Carty, Michael P. and Aldabbagh, Fawaz (2016) Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones : very strong correlation to pleurotin and thioredoxin reductase inhibition. Bioorganic & Medicinal Chemistry, 24(16), pp. 3565-3570. ISSN (print) 0968-0896

Shirazi, Reyhaneh Neghabat, Aldabbagh, Fawaz, Ronan, William, Erxleben, Andrea, Rochev, Yury and McHugh, Peter (2016) Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance. Journal of Materials Science: Materials in Medicine, 27(154), ISSN (print) 0957-4530

Gurry, Michael and Aldabbagh, Fawaz (2016) A new era for homolytic aromatic substitution : replacing Bu[sub]3SnH with efficient light-induced chain reactions. Organic & Biomolecular Chemistry, 14(16), pp. 3849-3862. ISSN (print) 1477-0520

Gurry, Michael, Sweeney, Martin, McArdle, Patrick and Aldabbagh, Fawaz (2015) One-pot hydrogen peroxide and hydrohalic acid induced ring closure and selective aromatic halogenation to give new ring-fused benzimidazoles. Organic Letters, 17(11), pp. 2856-2859. ISSN (print) 1523-7060

Hawkins, Gerard, Zetterlund, Per B and Aldabbagh, Fawaz (2015) RAFT polymerization in supercritical carbon dioxide based on an induced precipitation approach : synthesis of 2-ethoxyethyl methacrylate/acrylamide block copolymers. Journal of Polymer Science Part A : Polymer Chemistry, 53(20), pp. 2351-2356. ISSN (print) 0887-624X

Gurry, Michael, McArdle, Patrick and Al-Dabbagh, Fawaz (2015) Synthesis of a Spirocyclic Oxetane-Fused Benzimidazole. Molecules, 20(8), pp. 13864-13874. ISSN (print) 1431-5165

Magee, Christopher, Sugihara, Yusuke, Zetterlund, Per B and Aldabbagh, Fawaz (2014) Chain transfer to solvent in the radical polymerization of structurally diverse acrylamide monomers using straight-chain and branched alcohols as solvents. Polymer Chemistry, 5(7), pp. 2259-2265. ISSN (print) 1759-9954

Shirazi, Reyhaneh Neghabat, Aldabbagh, Fawaz, Erxleben, Andrea, Rochev, Yury and McHugh, Peter (2014) Nanomechanical properties of poly(lactic-co-glycolic) acid film during degradation. Acta Biomaterialia, 10(11), pp. 4695-4703. ISSN (print) 1742-7061

Gurry, Michael, Allart-Simon, Ingrid, McArdle, Patrick, Gerard, Stephane, Sapi, Janos and Aldabbagh, Fawaz (2014) Photochemical aryl radical cyclizations to give (E)-3-Ylideneoxindoles. Molecules, 19(10), pp. 15891-15899. ISSN (online) 1420-3049

Magee, Christopher, Earla, Aruna, Petraitis, Jennifer, Higa, Chad, Braslau, Rebecca, Zetterlund, Per B and Aldabbagh, Fawaz (2014) Synthesis of fluorinated alkoxyamines and alkoxyamine-initiated nitroxide-mediated precipitation polymerizations of styrene in supercritical carbon dioxide. Polymer Chemistry, 5, pp. 5725-5733. ISSN (print) 1759-9954

Coyle, Robert, McArdle, Patrick and Aldabbagh, Fawaz (2014) Tandem reactions via Barton esters with intermolecular addition and vinyl radical substitution onto indole. The Journal of Organic Chemistry, 79(12), pp. 5903-5907. ISSN (print) 0022-3263

Vo, Tuoi T. N., Yang, Rongbing, Aldabbagh, Fawaz, Carroll, William, Meere, Martin and Rochev, Yury (2014) A thermally activated drug delivery system based on a thermoresponsive polymer and a cooling device : a theoretical assessment. Journal of Thermal Science and Engineering Applications, 6(2), 021012. ISSN (print) 1948-5085

This list was generated on Wed Aug 15 04:27:35 2018 BST.
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