Please enable JavaScript in your web browser to get the best experience.

Please enable JavaScript in your web browser to get the best experience.

Clearing Study Experience Research Collaborate About us

Dr Alan Seddon

Faculty of Health, Science, Social Care and Education
Department of Applied and Human Sciences
School of Life Sciences, Pharmacy and Chemistry
Penrhyn Road

Visiting Senior Fellow

[email protected]

About

I started my lecturing career in the Department of Biological Sciences at the University of Calabar, Nigeria between 1980 and 1984 after completing my PhD at North East London Polytechnic (now the University of East London). Prior to joining Kingston, I worked for more than six years as a Research Fellow in the Department of Histopathology at University College London and Middlesex School of Medicine.

I joined Kingston University as a Senior Lecturer in Environmental Biology in 1991 and was promoted in 1997 to Principal Lecturer. I was appointed substantive Head of the School of Life Sciences in 2007, having previously been Acting Head (2004–07) and Acting Deputy Head (2002–04).

I retired from the Head of School post at the end of July 2014, but returned part-time as Associate Professor in Life Sciences. I continued to teach on several biomedical science modules and helped supervise a number of postgraduate students.

I finally retired from this position at the end of August 2022, but continue to advise several postgraduate students and maintain research links with Professors Modjtahedi and Karlyshev.

Qualifications

PhD
PGDip Biometry
M I Biol
HND Applied Biology

Domains

Publications

Expression of EGFRvIII and its co-expression with wild-type EGFR, or putative cancer stem cell biomarkers CD44 or EpCAM are associated with poorer prognosis in patients with hepatocellular carcinoma

Sherif, Ozlem, Khelwatty, Said A., Bagwan, Izhar, Seddon, Alan M., Dalgleish, Angus, Mudan, Satvinder and Modjtahedi, Helmout, 2024, Oncology Reports (52), 6, Published

View this article

The combination of afatinib with dasatinib or miransertib results in synergistic growth inhibition of stomach cancer cells

Al-Janaby, Tina, Nahi, Narmin, Seddon, Alan, Bagwan, Izhar, Khelwatty, Said and Modjtahedi, Helmout, 2024, World Journal of Oncology (15), 2 pp 192-208, Published

View this article

The co-expression of HER family members and CD109 is common in pancreatic cancer

Khan, Tanzeel, Seddon, Alan, Khelwatty, Said, Dalgleish, Angus, Bagwan, Izhar, Mudan, Satvinder and Modjtahedi, Helmout, 2023, Medical Research Archives (11), 11, Published

View this article

Detection of high-risk human papillomavirus in prostate cancer from a UK based population

Ahmed, M. Yahya, Salman, Nadia Aziz, Sandhu, Sarbjinder, Cakir, M. Okan, Seddon, Alan M., Kuehne, Christian and Ashrafi, G. Hossein, 2023, Scientific Reports (13), 1, Published

View this article

HER2 expression is predictive of survival in cetuximab treated patients with RAS wild type metastatic colorectal cancer

Khelwatty, Said A., Puvanenthiran, Soozana, Essapen, Sharadah, Bagwan, Izhar, Seddon, Alan M. and Modjtahedi, Helmout, 2021, Cancers (13), 4, Published

View this article

Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: implications for future clinical trials in pancreatic cancer

Khan, Tanzeel, Seddon, Alan M., Dalgleish, Angus G., Khelwatty, Said, Ioannou, Nikolaos, Mudan, Satvinder and Modjtahedi, Helmout, 2020, Oncology Reports (44), 6 pp 2581-2594, Published

View this article

Co-expression and prognostic significance of putative CSC markers CD44, CD133, wild-type EGFR and EGFRvIII in metastatic colorectal cancer

Khelwatty, Said Abdullah, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan M. and Modjtahedi, Helmout, 2019, Oncotarget (10), 18 pp 1704-1715, Published

View this article

Co-expression and prognostic significance of the HER family members, EGFRvIII, c-MET, CD44 in patients with ovarian cancer

Puvanenthiran, Soozana, Essapen, Sharadah, Haagsma, Ben, Bagwan, Izhar, Green, Margaret, Khelwatty, Said Abdullah, Seddon, Alan and Modjtahedi, Helmout, 2018, Oncotarget (9) pp 19662-19674, Published

View this article

CmeABC multidrug efflux pump contributes to antibiotic resistance and promotes 'Campylobacter jejuni' survival and multiplication in 'Acanthamoeba polyphaga'

Karlyshev, Andrey, Vieira, Ana, Ramesh, Amritha and Seddon, Alan, 2017, Applied and Environmental Microbiology (83), 22, Published

View this article

Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines

Stanley, Aryan, Ashrafi, G. Hossein, Seddon, Alan M. and Modjtahedi, Helmout, 2017, Scientific Reports (7), 3964, Published

View this article

The hidden perils of read mapping as a quality assessment tool in genome sequencing

Seddon, A. M., Karlyshev, A. V. and Lehri, B., 2017, Scientific Reports (7), 43149, Published

View this article

Potential probiotic-associated traits revealed from completed high quality genome sequence of Lactobacillus fermentum 3872

Lehri, Burhan, Seddon, Alan M. and Karlyshev, Andrey V., 2017, Standards in Genomic Sciences (12), 19, Published

View this article

'Lactobacillus fermentum' 3872 as a potential tool for combatting 'Campylobacter jejuni' infections

Lehri, B., Seddon, A. M. and Karlyshev, A. V., 2017, Virulence (8), 8 pp 1753-1760, Published

View this article

The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer

Khelwatty, Said, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan and Modjtahedi, Helmout, 2016, Oncotarget (8), 5 pp 7666-7677, Published

View this article

Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of the HER inhibitors and cytotoxic drugs

Puvanenthiran, Soozana, Essapen, Sharadah, Seddon, Alan M. and Modjtahedi, Helmout, 2016, International Journal of Oncology (49), 5 pp 1825-1838, Published

View this article

YPTB3816 of 'Yersinia pseudotuberculosis' strain IP32953 is a virulence-related metallo-oligopeptidase

Ford, Donna C., Cooper, Ian A., Wren, Brendan W., Oyston, Petra C. F., Karlyshev, Andrey V., Atas, Ali and Seddon, Alan M., 2016, BMC Microbiology (16), 282, Published

View this article

Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition

Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, Mackintosh, David, Solca, Flavio and Modjtahedi, Helmout, 2016, International Journal of Oncology (48), 3 pp 908-918, Published

View this article

Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers

Khelwatty, Said A., Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout, 2015, British Journal of Cancer (113), 7 pp 1010-1019, Published

View this article

' Lactobacillus fermentum ' 3872 genome sequencing reveals plasmid and chromosomal genes potentially involved in a probiotic activity.

Lehri, Burhan, Seddon, Alan and Karlyshev, Andrey, 2015, FEMS Microbiology Letters (362), 11, Published

View this article

Campylobacter-Acanthamoeba interactions

Vieira, Ana, Seddon, Alan and Karlyshev, Andrey V., 2015, Microbiology (United Kingdom) (161), 5 pp 933-947, Published

View this article

A negative effect of Campylobacter capsule on bacterial interaction with an analogue of a host cell receptor

Rubinchik, Sona, Seddon, Alan and Karlyshev, Andrey, 2014, BMC Microbiology (14), 141, Published

View this article

Co-expression of HER family members in patients with Dukes' C and D colon cancer and their impacts on patient prognosis and survival.

Khelwatty, Said Abdullah, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan Michael and Modjtahedi, Helmout, 2014, PLoS ONE (9), 3, Published

View this article

Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells

Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, Mackintosh, David and Modjtahedi, Helmout, 2013, BMC Cancer (13), 41, Published

View this article

Prognostic significance and targeting of HER family in colorectal cancer

Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan Michael and Modjtahedi, Helmout, 2013, Frontiers in Bioscience (18), 2 pp 394-421, Published

View this article

Molecular mechanisms and biological role of Campylobacter jejuni attachment to host cells

Rubinchik, S., Seddon, A. and Karlyshev, Andrey V., 2012, European Journal of Microbiology and Immunology (2), 1 pp 32-40, Published

View this article

Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10

Modjtahedi, H., Khelwatty, S. A., Kirk, R. S., Seddon, A. M., Essapen, S., Del Vecchio, C. A., Wong, A. J. and Eccles, S., 2012, British Journal of Cancer (106) pp 883-888, Published

View this article

Expression pattern and targeting of HER family members and IGF-IR in pancreatic cancer

Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, MacKintosh, David and Modjtahedi, Helmout, 2012, Frontiers in Bioscience (17), 1 pp 2698-2724, Published

View this article

Three-dimensional visualisation of developmental stages of an apicomplexan fish blood parasite in its invertebrate host

Hayes, Polly M., Wertheim, David F., Smit, Nico J., Seddon, Alan M. and Davies, Angela J., 2011, Parasites & Vectors (4), Published

View this article

Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells

Ioannou, N., Dalgleish, A. G., Seddon, A. M., MacKintosh, D., Guertler, U., Solca, F. and Modjtahedi, H., 2011, British Journal of Cancer (105), 10 pp 1554-1562, Published

View this article

Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members

Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan M. and Modjtahedi, Helmout, 2011, International Journal of Oncology (39), 2 pp 483-491, Published

View this article

Cell cycle and cancer: cycling out of control

Puyol, Marta, Seddon, Alan and Khan, Gulfaraz, 2006, Pakistan Journal of Pathology (17), 2 pp 85-89, Published

View this article

Haemogregarina bigemina (Protozoa: Apicomplexa: Adelorina) - Past, present and future

Davies, Angela J., Smit, Nico J., Hayes, Polly M., Seddon, Alan M. and Wertheim, David, 2004, Folia Parasitologica (51), 3 pp 99-108, Published

View this article

The acute 1-week effects of the Zone diet on body composition, blood lipid levels, and performance in recreational endurance athletes

Jarvis, Mark, Seddon, Alan, McNaughton, Lars and Thompson, Dylan, 2002, Journal of Strength and Conditioning Research (16), 1 pp 50-57, Published

View this article