3-(diphenylamino)-4-ethoxycyclobut-3-ene-1,2-dione
Long, Nathan, Paval, Emanuela, Bear, Joseph C., Cockcroft, Jeremy K. and Wren, Stephen P., 2026, MolBank (2026), 3, Published
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Fair and square: design, synthesis and biological evaluations of squaric acid derivatives as novel HDAC8 inhibitors
Long, Nathan, Meyer‐Almes, Franz‐Josef, Kopranovic, Aleksandra and Wren, Stephen P., 2026, ChemMedChem (21), 8, Published
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KISS1R antagonism as a promising anti-cancer approach: an overview on function, molecular mechanisms and therapeutic potential
Scanlon, James J, Bristow, Aidan P, Chioni, Athina-Myrto and Wren, Stephen P, 2024, Journal on Oncology, Published
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Design and preparation of a fluorescent molecularly imprinted membrane for the selective detection of pepsin enzyme as a biomarker for gastroesophageal reflux disease
Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James, 2024, Talanta Open, E-pub ahead of print
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Suramin: effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug
Steverding, Dietmar, Tinson, Ryan A.J., Piras, Monica, Wren, Stephen P., Rushworth, Stuart A., Searcey, Mark and Troeberg, Linda, 2024, Experimental Parasitology (260), Published
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Development of highly sensitive fluorescent sensors for separation-free detection and quantitation systems of pepsin enzyme applying a structure-guided approach
Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James, 2024, Biosensors (14), 3, Published
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Synthesis and evaluation of druglike parameters via 'in silico' techniques for a series of heterocyclic monosquarate-amide derivatives as potential carboxylic acid bioisosteres
Long, N., Le Gresley, A., Wozniak, A., Brough, S. and Wren, S. P., 2024, Bioorganic and Medicinal Chemistry (98), Published
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Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue
Green, Jonathan, Tinson, Ryan A.J., Betts, Jacob H.J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen P., Searcey, Mark and Troeberg, Linda, 2023, Bioorganic and Medicinal Chemistry (92), Published
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Synthesis of squaric acid monoamides as building blocks for drug discovery
Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve and Wren, Stephen Paul, 2023, SynOpen, Accepted/In press
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Development of magnetic molecularly imprinted polymers for the extraction of salivary pepsin prior to analysis by a novel HPLC-SEC method
Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James, 2022, Polymer (261), Published
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A computational chemistry-driven hypothesis on the mode of action of hipposudoric acid and related analogs
Araar, Islam M. and Wren, Stephen P., 2022, Future Medicinal Chemistry, E-pub ahead of print
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Fructose malabsorption: causes, diagnosis and treatment
Benardout, Miles, Le Gresley, Adam, Elshaer, Amr and Wren, Stephen P., 2022, British Journal of Nutrition (127), 4 pp 481-489, Published
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Review on molecularly imprinted polymers with a focus on their application to the analysis of protein biomarkers
Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P. and Barker, James, 2021, TrAC - Trends in Analytical Chemistry (144), Published
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Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection
Paulsson-Habegger, Lukas, Snabaitis, Andrew K. and Wren, Stephen P., 2021, Bioorganic and Medicinal Chemistry (48), Published
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Thiazolidinediones: an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus
Long, Nathan, Le Gresley, Adam and Wren, Stephen P., 2021, ChemMedChem (16), 11 pp 1717-1736, Published
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In silico design of bioisosteric modifications of drugs for the treatment of diabetes
Vink, Guillaume, Nebel, Jean Christophe and Wren, Stephen P., 2021, Future Medicinal Chemistry (13), 8 pp 691-700, Published
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Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres
Scanlon, James J. and Wren, Stephen P., 2020, Future Medicinal Chemistry (12), 20 pp 1855-1864, Published
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Immuno-oncology: the next generation of breakthrough therapies. Highlights from The Society for Medicines Research Symposium. Oxford, UK - June 21, 2019
Ritchie, James, Sykes, Andy, Weber, Peter and Wren, Stephen P., 2019, Drugs of the Future (44), 7 pp 599-604, Published
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Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3
Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D., Bambridge, Gabriel, Wren, Stephen P., Nagase, Hideaki and Troeberg, Linda, 2017, Molecular Pharmacology (92), 4 pp 459-468, Published
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Computational design and fabrication of optical fibre fluorescent chemical probes for the detection of cocaine
Wren, Stephen P., Piletsky, Sergey A., Karim, Kal, Gascoine, Paul, Lacey, Richard, Sun, Tong and Grattan, Kenneth T.V., 2015, Journal of Lightwave Technology (33), 12 pp 2572-2579, Published
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Silver@graphene oxide nanocomposite-based optical sensor platform for biomolecules
Zangeneh Kamali, Khosro, Pandikumar, Alagarsamy, Sivaraman, Gandhi, Lim, Hong Ngee, Wren, Stephen Paul, Sun, Tong and Huang, Nay Ming, 2015, RSC Advances (5), 23 pp 17809-17816, Published
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Preparation of novel optical fibre-based cocaine sensors using a molecular imprinted polymer approach
Wren, Stephen P., Nguyen, T. Hien, Gascoine, Paul, Lacey, Richard, Sun, Tong and Grattan, Kenneth T.V., 2014, Sensors and Actuators B: Chemical (193) pp 35-41, Published
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