Dr Adam Le Gresley

About

I obtained my PhD from the University of Surrey in 2004, working under Professor Nikolai Kuhnert on the synthesis of Calix[4]arene derivatives for dynamic combinatorial libraries. I undertook my postdoctoral work as an NIH Research Fellow at Drexel College of Medicine in the USA, where I worked on the synthesis and evaluation of "caged" compounds for probing biological pathways in the brain.

Since joining Kingston University in 2009, I have established a research group in organic and analytical chemistry, funded by industrial sponsors such as GlaxoSmithKline, LGC Ltd and Innovate UK, working on the design and synthesis of fluorogenic compounds for problem pathogen detection and method development for NMR metabolomics/2D qNMR for complex mixture analysis and metrology. I have collaborations with institutions in Germany, Australia and the USA.

Contact Details:

Address: PRMB2017, Kingston University, London, KT1 2EE

Tel: +44 (0)208 4177432

Email: a.legresley@kingston.ac.uk

Academic responsibilities

School Director of Research and Enterprise

Qualifications

  • 2009-2010: Postgraduate Certificate in Higher Education - Kingston University.
  • 2000-2004: PhD in Organic and Supramolecular Chemistry - University of Surrey.
  • 1996-2000: BSc(Hons) Chemistry with a Industrial Placement - University of Surrey.

Teaching and learning

Research

My team currently consists of the following excellent researchers;

  • Probing redox pathways for novel antioxidants for Skin Health - funded by GSK - Postdoc - Dr Matteo Zecchini
  • 2D NMR techniques for Skin Health products - funded by GSK - PhD Student - Cameron Robertson
  • Novel organic peroxide synthesis and evaluation - funded by GSK - PhD Student - Grace Broadberry
  • Synthesis of Anthracene-bis(acrylamido) derivatives - PhD Student - Tomris Coban
  • Synthesis of novel Halicholine derivatives by bi-directional reactions - PhD Student - Alex Fudger
  • Lipid oxidation product analysis by NMR in various heating models - PhD Student - Gilbert Ampem

I am also involved in a number of cross-faculty research projects aided by UG/PG project students.

Alumni

  • Dr Luke Bywaters
  • Dr Samerah Malik
  • Dr Fahmina Fardus
  • Dr Baljeet Kaur

Areas of specialism

  • Organic Chemistry
  • NMR
  • Skin Science
  • Food Chemistry

Scholarly affiliations

  • Fellow of the Royal Society of Chemistry
  • Fellow of the Higher Education Academy

Research student supervision

Main supervision

Other supervision

Publications

Number of items: 32.

Article

Malik, Samerah, Sinclair, Alex, Ryan, Ali and Le Gresley, Adam (2020) Synthesis and initial evaluation of a novel fluorophore for selective FMDV 3C Protease detection. Molecules, 25(16), p. 3599. ISSN (online) 1420-3049

Percival, Benita C., Wann, Angela, Zbasnik, Richard, Schlegel, Vicki, Edgar, Mark, Zhang, Jie, Ampem, Gilbert, Wilson, Philippe, Le Gresley, Adam, Naughton, Declan and Grootveld, Martin (2020) Evaluations of the peroxidative susceptibilities of cod liver oils by a ¹H NMR analysis strategy : peroxidative resistivity of a natural collagenous and biogenic amine-rich fermented product. Nutrients, 12(3), p. 753. ISSN (print) 2072-6643

Robertson, Cameron, Lucas, Robert A. and Le Gresley, Adam (2020) Scope and limitations of nuclear magnetic resonance techniques for characterisation and quantitation of vitamin D in complex mixtures. Skin Research and Technology, 26(1), pp. 112-120. ISSN (print) 0909-752X

Bywaters, Luke and Le Gresley, Adam (2020) Synthesis and spectral properties of novel Singapore Green analogues for protease detection. Scientific Reports, 10, p. 259. ISSN (online) 2045-2322

Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin, Percival, Benita C. and Naughton, Declan P. (2019) Characterisation of peroxidation products arising from culinary oils exposed to continuous and discontinuous thermal degradation processes. Food and Function, 10, pp. 7952-7966. ISSN (print) 2042-6496

Zecchini, Matteo, Lucas, Robert and Le Gresley, Adam (2019) New insights into the cystine-sulfite reaction. Molecules, 24(13), p. 2377. ISSN (online) 1420-3049

Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean-Marie, Robinson, Joshua and O'Leary, Shane (2019) Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil. Journal of Analytical and Applied Pyrolysis, 140, pp. 281-289. ISSN (print) 0165-2370

Le Gresley, Adam and Peron, Jean-Marie R. (2019) A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis. Food Chemistry, 275, pp. 385-389. ISSN (print) 0308-8146

Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana and Ashrafi, G. Hossein (2019) Biological activities for 'Ficus carica' latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers. Scientific Reports, 9(1013), ISSN (online) 2045-2322

Vienescu, D.N., Wang, J., Le-Gresley, A. and Nixon, J.D. (2018) A life cycle assessment of options for producing synthetic fuel via pyrolysis. Bioresource Technology, 249, pp. 626-634. ISSN (print) 0960-8524

Butt, Ummara, ElShaer, Amr, Snyder, Lori A. S., Al-Kinani, Ali A., Le Gresley, Adam and Alany, Raid G. (2018) Fatty acid based microemulsions to combat ophthalmia neonatorum caused by 'Neisseria gonorrhoeae' and 'Staphylococcus aureus'. Nanomaterials, 8(1), p. 51. ISSN (online) 2079-4991

Bywaters, Luke, Mulcahy-Ryan, Lauren, Fielder, Mark, Sinclair, Alex and Le Gresley, Adam (2017) Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of 'Staphylococcus aureus'. Molecular and Cellular Probes, 36, pp. 1-9. ISSN (print) 0890-8508

Fardus-Reid, Fahmina, Warren, John and Le Gresley, Adam (2016) Validating heteronuclear 2D quantitative NMR. Analytical Methods, 8(9), pp. 2013-2019. ISSN (print) 1759-9660

Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E (2016) Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents. Organic & Biomolecular Chemistry, 14, pp. 3069-3079. ISSN (print) 1477-0520

Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert (2015) The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries. Analytical Methods, 7(6), p. 2323.

Le Gresley, Adam, Fardus, Fahmina and Warren, John (2015) Bias and uncertainty in non-ideal qNMR Analysis. Critical reviews in analytical chemistry / CRC, 45(4), pp. 300-10. ISSN (print) 1547-6510

Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam (2013) Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments. Organic & Biomolecular Chemistry, 11(20), pp. 3307-3313. ISSN (print) 1477-0520

Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039

Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D (2012) The application of high resolution diffusion NMR to the analysis of manuka honey. Food Chemistry, 135(4), pp. 2879-86. ISSN (print) 0308-8146

Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza, Lafon, Shehri and Sinclair, Alex (2011) Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2(6), pp. 466-470. ISSN (print) 2040-2503

Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri (2010) Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands. Synthetic Communications, 41(16), pp. 2483-2492. ISSN (print) 0039-7911

Le-Gresley, A and Kuhnert, N (2010) The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries. Journal of Chemical Research, 2, pp. 61-67. ISSN (print) 1747-5198

Kuhnert, Nikolai and Le Gresley, Adam (2008) Synthesis of upper rim calix[4]arene carcerands. Tetrahedron Letters, 49(7), pp. 1274-1276. ISSN (print) 0040-4039

Kuhnert, Nikolai, Le Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana (2007) Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer. Journal of Labelled Compounds and Radiopharmaceuticals, 50(13), pp. 1215-1223. ISSN (print) 0362-4803

Kuhnert, Nikolai and Le Gresley, Adam (2005) Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes. Organic & Biomolecular Chemistry, 3(11), pp. 2175-2182. ISSN (print) 1477-0520

Kuhnert, Nikolai and Le-Gresley, Adam (2005) The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries. Tetrahedron Letters, 46(12), pp. 2059-2062. ISSN (print) 0040-4039

Kuhnert, Nikolai and Le-Gresley, Adam (2003) The synthesis of tetra-acrylamido-calix[4]arene capsules. Chemical Communications, 19, pp. 2426-2427. ISSN (print) 1359-7345

Kuhnert, Nikolai and Le Gresley, Adam (2001) On the scope and limitations of the Heck reaction of upper rim tetraiodocalix[4]arenes. Perkin Transactions 1, 24, pp. 3393-3398. ISSN (print) 1472-7781

Conference or Workshop Item

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)

Le Gresley, Adam, Gollapalli, Uma [Contributor] and Ghosh, Uttam [Contributor] (2009) The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR. In: National Cancer Research Institute Cancer Conference; 04 -07 Oct 2009, Birmingham, U.K.. (Unpublished)

Le Gresley, Adam and Kuhnert, Nikolai [Contributor] (2009) The synthesis of novel calix[4]arene tetra-acrylates and their potential use as macrocyclic platforms in the development of static and dynamic combinatorial libraries using reversible imine formation. In: IUPAC Conference; , Glasgow, UK. (Unpublished)

Patent

Sinclair, Alex [Inventor], Fielder, Mark [Inventor] and Le Gresley, Adam [Inventor] (2013) Kingston University Higher Education Corporation Rhodamine based fluorescent probe for coagulase activity and detection of coagulase producing bacterial strains. WO 2014013272 A1.

This list was generated on Sun Oct 25 06:40:51 2020 GMT.

Business, knowledge transfer and international

Industry links

  • GlaxoSmithKline
  • LGC Ltd

Videos of my work

Social media

LinkedIn