I obtained my PhD from the University of Surrey in 2004, working under Professor Nikolai Kuhnert on the synthesis of Calixarene derivatives for dynamic combinatorial libraries. I undertook my postdoctoral work as an NIH Research Fellow at Drexel College of Medicine in the USA, where I worked on the synthesis and evaluation of "caged" compounds for probing biological pathways in the brain.
Since joining Kingston University in 2009, I have established a research group in organic and analytical chemistry, funded by industrial sponsors such as GlaxoSmithKline, LGC Ltd and Innovate UK, working on the design and synthesis of fluorogenic compounds for problem pathogen detection and method development for NMR metabolomics/2D qNMR for complex mixture analysis and metrology. I have collaborations with institutions in Germany, Australia and the USA.
Address: PRMB2017, Kingston University, London, KT1 2EE
Tel: +44 (0)208 4177432
School Director of Research and Enterprise
Online Lectures for Lecturio GmbH, an online medical course.
My team currently consists of the following excellent researchers;
I am also involved in a number of cross-faculty research projects aided by UG/PG project students.
Malik, Samerah, Sinclair, Alex, Ryan, Ali and Le Gresley, Adam (2020) Synthesis and initial evaluation of a novel fluorophore for selective FMDV 3C Protease detection. Molecules, 25(16), p. 3599. ISSN (online) 1420-3049
Percival, Benita C., Wann, Angela, Zbasnik, Richard, Schlegel, Vicki, Edgar, Mark, Zhang, Jie, Ampem, Gilbert, Wilson, Philippe, Le Gresley, Adam, Naughton, Declan and Grootveld, Martin (2020) Evaluations of the peroxidative susceptibilities of cod liver oils by a ¹H NMR analysis strategy : peroxidative resistivity of a natural collagenous and biogenic amine-rich fermented product. Nutrients, 12(3), p. 753. ISSN (print) 2072-6643
Robertson, Cameron, Lucas, Robert A. and Le Gresley, Adam (2020) Scope and limitations of nuclear magnetic resonance techniques for characterisation and quantitation of vitamin D in complex mixtures. Skin Research and Technology, 26(1), pp. 112-120. ISSN (print) 0909-752X
Bywaters, Luke and Le Gresley, Adam (2020) Synthesis and spectral properties of novel Singapore Green analogues for protease detection. Scientific Reports, 10, p. 259. ISSN (online) 2045-2322
Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin, Percival, Benita C. and Naughton, Declan P. (2019) Characterisation of peroxidation products arising from culinary oils exposed to continuous and discontinuous thermal degradation processes. Food and Function, 10, pp. 7952-7966. ISSN (print) 2042-6496
Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean-Marie, Robinson, Joshua and O'Leary, Shane (2019) Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil. Journal of Analytical and Applied Pyrolysis, 140, pp. 281-289. ISSN (print) 0165-2370
Le Gresley, Adam and Peron, Jean-Marie R. (2019) A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis. Food Chemistry, 275, pp. 385-389. ISSN (print) 0308-8146
Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana and Ashrafi, G. Hossein (2019) Biological activities for 'Ficus carica' latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers. Scientific Reports, 9(1013), ISSN (online) 2045-2322
Vienescu, D.N., Wang, J., Le-Gresley, A. and Nixon, J.D. (2018) A life cycle assessment of options for producing synthetic fuel via pyrolysis. Bioresource Technology, 249, pp. 626-634. ISSN (print) 0960-8524
Butt, Ummara, ElShaer, Amr, Snyder, Lori A. S., Al-Kinani, Ali A., Le Gresley, Adam and Alany, Raid G. (2018) Fatty acid based microemulsions to combat ophthalmia neonatorum caused by 'Neisseria gonorrhoeae' and 'Staphylococcus aureus'. Nanomaterials, 8(1), p. 51. ISSN (online) 2079-4991
Bywaters, Luke, Mulcahy-Ryan, Lauren, Fielder, Mark, Sinclair, Alex and Le Gresley, Adam (2017) Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of 'Staphylococcus aureus'. Molecular and Cellular Probes, 36, pp. 1-9. ISSN (print) 0890-8508
Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E (2016) Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents. Organic & Biomolecular Chemistry, 14, pp. 3069-3079. ISSN (print) 1477-0520
Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert (2015) The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries. Analytical Methods, 7(6), p. 2323.
Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam (2013) Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments. Organic & Biomolecular Chemistry, 11(20), pp. 3307-3313. ISSN (print) 1477-0520
Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039
Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D (2012) The application of high resolution diffusion NMR to the analysis of manuka honey. Food Chemistry, 135(4), pp. 2879-86. ISSN (print) 0308-8146
Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza, Lafon, Shehri and Sinclair, Alex (2011) Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2(6), pp. 466-470. ISSN (print) 2040-2503
Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri (2010) Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands. Synthetic Communications, 41(16), pp. 2483-2492. ISSN (print) 0039-7911
Le-Gresley, A and Kuhnert, N (2010) The design and synthesis of acrylato and imino derivatives of calixarene for applications in static and dynamic combinatorial libraries. Journal of Chemical Research, 2, pp. 61-67. ISSN (print) 1747-5198
Kuhnert, Nikolai, Le Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana (2007) Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer. Journal of Labelled Compounds and Radiopharmaceuticals, 50(13), pp. 1215-1223. ISSN (print) 0362-4803
Kuhnert, Nikolai and Le Gresley, Adam (2005) Synthesis and capsule formation of upper rim substituted tetra-acrylamido calixarenes. Organic & Biomolecular Chemistry, 3(11), pp. 2175-2182. ISSN (print) 1477-0520
Kuhnert, Nikolai and Le-Gresley, Adam (2005) The use of deep cavity tetraformyl calixarenes in the synthesis of static and dynamic macrocyclic libraries. Tetrahedron Letters, 46(12), pp. 2059-2062. ISSN (print) 0040-4039
Kuhnert, Nikolai and Le-Gresley, Adam (2003) The synthesis of tetra-acrylamido-calixarene capsules. Chemical Communications, 19, pp. 2426-2427. ISSN (print) 1359-7345
Kuhnert, Nikolai and Le Gresley, Adam (2001) On the scope and limitations of the Heck reaction of upper rim tetraiodocalixarenes. Perkin Transactions 1, 24, pp. 3393-3398. ISSN (print) 1472-7781
Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)
Le Gresley, Adam, Gollapalli, Uma [Contributor] and Ghosh, Uttam [Contributor] (2009) The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR. In: National Cancer Research Institute Cancer Conference; 04 -07 Oct 2009, Birmingham, U.K.. (Unpublished)
Le Gresley, Adam and Kuhnert, Nikolai [Contributor] (2009) The synthesis of novel calixarene tetra-acrylates and their potential use as macrocyclic platforms in the development of static and dynamic combinatorial libraries using reversible imine formation. In: IUPAC Conference; , Glasgow, UK. (Unpublished)
Sinclair, Alex [Inventor], Fielder, Mark [Inventor] and Le Gresley, Adam [Inventor] (2013) Kingston University Higher Education Corporation Rhodamine based fluorescent probe for coagulase activity and detection of coagulase producing bacterial strains. WO 2014013272 A1.