Dr Alan Seddon
Faculties, departments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Applied and Human Sciences
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Visiting Senior Fellow
- Email:
- [email protected]
About
I started my lecturing career in the Department of Biological Sciences at the University of Calabar, Nigeria between 1980 and 1984 after completing my PhD at North East London Polytechnic (now the University of East London). Prior to joining Kingston, I worked for more than six years as a Research Fellow in the Department of Histopathology at University College London and Middlesex School of Medicine.
I joined Kingston University as a Senior Lecturer in Environmental Biology in 1991 and was promoted in 1997 to Principal Lecturer. I was appointed substantive Head of the School of Life Sciences in 2007, having previously been Acting Head (2004–07) and Acting Deputy Head (2002–04).
I retired from the Head of School post at the end of July 2014, but returned part-time as Associate Professor in Life Sciences. I continued to teach on several biomedical science modules and helped supervise a number of postgraduate students.
I finally retired from this position at the end of August 2022, but continue to advise several postgraduate students and maintain research links with Professors Modjtahedi and Karlyshev.
Qualifications
- PhD
- PGDip Biometry
- M I Biol
- HND Applied Biology
Domains
I continue to advise several postgraduate students and maintain research links with Professor Modjtahedi and Professor Karlyshev.
Qualifications
- PhD
Publications
Expression of EGFRvIII and its co-expression with wild-type EGFR, or putative cancer stem cell biomarkers CD44 or EpCAM are associated with poorer prognosis in patients with hepatocellular carcinoma
Sherif, Ozlem, Khelwatty, Said A., Bagwan, Izhar, Seddon, Alan M., Dalgleish, Angus, Mudan, Satvinder and Modjtahedi, Helmout, 2024, Oncology Reports (52), 6, Published
The combination of afatinib with dasatinib or miransertib results in synergistic growth inhibition of stomach cancer cells
Al-Janaby, Tina, Nahi, Narmin, Seddon, Alan, Bagwan, Izhar, Khelwatty, Said and Modjtahedi, Helmout, 2024, World Journal of Oncology (15), 2pp 192-208, Published
The co-expression of HER family members and CD109 is common in pancreatic cancer
Khan, Tanzeel, Seddon, Alan, Khelwatty, Said, Dalgleish, Angus, Bagwan, Izhar, Mudan, Satvinder and Modjtahedi, Helmout, 2023, Medical Research Archives (11), 11, Published
Detection of high-risk human papillomavirus in prostate cancer from a UK based population
Ahmed, M. Yahya, Salman, Nadia Aziz, Sandhu, Sarbjinder, Cakir, M. Okan, Seddon, Alan M., Kuehne, Christian and Ashrafi, G. Hossein, 2023, Scientific Reports (13), 1, Published
HER2 expression is predictive of survival in cetuximab treated patients with RAS wild type metastatic colorectal cancer
Khelwatty, Said A., Puvanenthiran, Soozana, Essapen, Sharadah, Bagwan, Izhar, Seddon, Alan M. and Modjtahedi, Helmout, 2021, Cancers (13), 4, Published
Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: implications for future clinical trials in pancreatic cancer
Khan, Tanzeel, Seddon, Alan M., Dalgleish, Angus G., Khelwatty, Said, Ioannou, Nikolaos, Mudan, Satvinder and Modjtahedi, Helmout, 2020, Oncology Reports (44), 6pp 2581-2594, Published
Co-expression and prognostic significance of putative CSC markers CD44, CD133, wild-type EGFR and EGFRvIII in metastatic colorectal cancer
Khelwatty, Said Abdullah, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan M. and Modjtahedi, Helmout, 2019, Oncotarget (10), 18pp 1704-1715, Published
Co-expression and prognostic significance of the HER family members, EGFRvIII, c-MET, CD44 in patients with ovarian cancer
Puvanenthiran, Soozana, Essapen, Sharadah, Haagsma, Ben, Bagwan, Izhar, Green, Margaret, Khelwatty, Said Abdullah, Seddon, Alan and Modjtahedi, Helmout, 2018, Oncotarget (9)pp 19662-19674, Published
CmeABC multidrug efflux pump contributes to antibiotic resistance and promotes 'Campylobacter jejuni' survival and multiplication in 'Acanthamoeba polyphaga'
Karlyshev, Andrey, Vieira, Ana, Ramesh, Amritha and Seddon, Alan, 2017, Applied and Environmental Microbiology (83), 22, Published
Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines
Stanley, Aryan, Ashrafi, G. Hossein, Seddon, Alan M. and Modjtahedi, Helmout, 2017, Scientific Reports (7), 3964, Published
The hidden perils of read mapping as a quality assessment tool in genome sequencing
Seddon, A. M., Karlyshev, A. V. and Lehri, B., 2017, Scientific Reports (7), 43149, Published
Potential probiotic-associated traits revealed from completed high quality genome sequence of Lactobacillus fermentum 3872
Lehri, Burhan, Seddon, Alan M. and Karlyshev, Andrey V., 2017, Standards in Genomic Sciences (12), 19, Published
'Lactobacillus fermentum' 3872 as a potential tool for combatting 'Campylobacter jejuni' infections
Lehri, B., Seddon, A. M. and Karlyshev, A. V., 2017, Virulence (8), 8pp 1753-1760, Published
The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer
Khelwatty, Said, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan and Modjtahedi, Helmout, 2016, Oncotarget (8), 5pp 7666-7677, Published
Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of the HER inhibitors and cytotoxic drugs
Puvanenthiran, Soozana, Essapen, Sharadah, Seddon, Alan M. and Modjtahedi, Helmout, 2016, International Journal of Oncology (49), 5pp 1825-1838, Published
YPTB3816 of 'Yersinia pseudotuberculosis' strain IP32953 is a virulence-related metallo-oligopeptidase
Ford, Donna C., Cooper, Ian A., Wren, Brendan W., Oyston, Petra C. F., Karlyshev, Andrey V., Atas, Ali and Seddon, Alan M., 2016, BMC Microbiology (16), 282, Published
Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition
Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, Mackintosh, David, Solca, Flavio and Modjtahedi, Helmout, 2016, International Journal of Oncology (48), 3pp 908-918, Published
Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers
Khelwatty, Said A., Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout, 2015, British Journal of Cancer (113), 7pp 1010-1019, Published
' Lactobacillus fermentum ' 3872 genome sequencing reveals plasmid and chromosomal genes potentially involved in a probiotic activity.
Lehri, Burhan, Seddon, Alan and Karlyshev, Andrey, 2015, FEMS Microbiology Letters (362), 11, Published
Campylobacter-Acanthamoeba interactions
Vieira, Ana, Seddon, Alan and Karlyshev, Andrey V., 2015, Microbiology (United Kingdom) (161), 5pp 933-947, Published
A negative effect of Campylobacter capsule on bacterial interaction with an analogue of a host cell receptor
Rubinchik, Sona, Seddon, Alan and Karlyshev, Andrey, 2014, BMC Microbiology (14), 141, Published
Co-expression of HER family members in patients with Dukes' C and D colon cancer and their impacts on patient prognosis and survival.
Khelwatty, Said Abdullah, Essapen, Sharadah, Bagwan, Izhar, Green, Margaret, Seddon, Alan Michael and Modjtahedi, Helmout, 2014, PLoS ONE (9), 3, Published
Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells
Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, Mackintosh, David and Modjtahedi, Helmout, 2013, BMC Cancer (13), 41, Published
Prognostic significance and targeting of HER family in colorectal cancer
Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan Michael and Modjtahedi, Helmout, 2013, Frontiers in Bioscience (18), 2pp 394-421, Published
Molecular mechanisms and biological role of Campylobacter jejuni attachment to host cells
Rubinchik, S., Seddon, A. and Karlyshev, Andrey V., 2012, European Journal of Microbiology and Immunology (2), 1pp 32-40, Published
Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10
Modjtahedi, H., Khelwatty, S. A., Kirk, R. S., Seddon, A. M., Essapen, S., Del Vecchio, C. A., Wong, A. J. and Eccles, S., 2012, British Journal of Cancer (106)pp 883-888, Published
Expression pattern and targeting of HER family members and IGF-IR in pancreatic cancer
Ioannou, Nikolaos, Seddon, Alan M., Dalgleish, Angus, MacKintosh, David and Modjtahedi, Helmout, 2012, Frontiers in Bioscience (17), 1pp 2698-2724, Published
Three-dimensional visualisation of developmental stages of an apicomplexan fish blood parasite in its invertebrate host
Hayes, Polly M., Wertheim, David F., Smit, Nico J., Seddon, Alan M. and Davies, Angela J., 2011, Parasites & Vectors (4), Published
Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells
Ioannou, N., Dalgleish, A. G., Seddon, A. M., MacKintosh, D., Guertler, U., Solca, F. and Modjtahedi, H., 2011, British Journal of Cancer (105), 10pp 1554-1562, Published
Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members
Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan M. and Modjtahedi, Helmout, 2011, International Journal of Oncology (39), 2pp 483-491, Published
Cell cycle and cancer: cycling out of control
Puyol, Marta, Seddon, Alan and Khan, Gulfaraz, 2006, Pakistan Journal of Pathology (17), 2pp 85-89, Published
Haemogregarina bigemina (Protozoa: Apicomplexa: Adelorina) - Past, present and future
Davies, Angela J., Smit, Nico J., Hayes, Polly M., Seddon, Alan M. and Wertheim, David, 2004, Folia Parasitologica (51), 3pp 99-108, Published
The acute 1-week effects of the Zone diet on body composition, blood lipid levels, and performance in recreational endurance athletes
Jarvis, Mark, Seddon, Alan, McNaughton, Lars and Thompson, Dylan, 2002, Journal of Strength and Conditioning Research (16), 1pp 50-57, Published
Expression of E. coli araE and mutated lacY genes in Campylobacter jejuni is not sufficient for arabinose transport
Karlyshev, Andrey, Seddon, Alan, Ramesh, Amritha, Rubinchik, Sona and Ikeda, Naomi(2017). [Published]
Molecular mechanisms of ' Campylobacter jejuni ' pathogenesis and survival in the environment
Vieira, Ana, Seddon, Alan and Karlyshev, Andrey(2016). [Published]
Potential use of ' Lactobacillus fermentum ' 3872 as an anti-campylobacter agent
Lehri, Burhan, Seddon, Alan and Karlyshev, Andrey(2016). [Published]
Acquired resistance to anti-EGFR mAb ICR62 or afatinib is accompanied by upregulation of the EGFR in colorectal cancer
Khelwatty, Said Abdullah, Essapen, Sharadah, Seddon, Alan M., Fan, Zhen and Modjtahedi, Helmout(2013). [Published]
Effect of capsule on interaction of Campylobacter jejuni cells with an analogue of a host cell receptor
Karlyshev, Andrey, Seddon, Alan and Rubinchik, Sona(2013). [Published]