Dr Ana Bolhaqueiro
Faculties, departments and locations
- Faculty of Health, Science, Social Care and Education
- Department of Biomolecular Sciences
- School of Life Sciences, Pharmacy and Chemistry
- Penrhyn Road
Lecturer in Biochemistry
- Email:
- [email protected]
About
During my PhD at the Hubrecht Institute (Utrecht, Netherlands) in Geert Kops' lab, my research focused on Cancer Biology and Genomic Instability in patient-derived tumour organoids. I investigated molecular mechanisms driving chromosomal instability in colorectal cancer, using long-term live imaging of chromosome segregation and single-cell DNA sequencing in organoid cultures derived from both healthy and colorectal cancer patient tissues.
As a postdoctoral researcher in Jean-Paul Vincent Lab at the Francis Crick Institute, I studied how the JNK stress pathway triggers seemingly opposite cell behaviours such as cell death, proliferation and cell cycle arrest. Using fruit flies as a model organism, I investigated the dynamic stress-related signalling that governs cell fate decisions and tissue repair. In 2020, I was awarded a Marie Skłodowska-Curie Individual Fellowship to support this research. Additionally, I was actively involved in teaching undergraduate students at University College London (UCL) and King's College London, which shaped my career direction.
In December 2024, I joined Kingston University as a Lecturer in Biochemistry.
Qualifications
- Postdoctoral Researcher at the Francis Crick Institute, London, United Kingdom (2020-2024)
- Associate Fellow of the Higher Education Academy (2022)
- PhD University of Utrecht / Hubrecht Institute, the Netherlands (2014-2019)
- MSc Cellular and Molecular Biology, University of Coimbra, Portugal (2012-2014)
- BSc (Hons) Biochemistry, University of Coimbra, Portugal (2009-2012)
Domains
Qualifications
- AFHEA (2022)
Courses taught
My research interests lie at the intersection of aneuploidy, stress signalling, and cancer biology. I focus on investigating the role of JNK stress signalling in cancer progression, metastasis, and therapeutic resistance, as well as its potential as a therapeutic target. The JNK pathway has dual, context-dependent roles, exhibiting both pro- and anti-tumorigenic effects, which are thought to depend on the cell type involved. I believe that unravelling the complexities of JNK signalling is one of the challenges in cancer research today.
Specialisms
- Confocal & Fluorescent Microscopy
- Cell, Molecular & Cancer Biology
- Drosophila melanogaster (fruit flies)
- Cell Stress Signalling
- Aneuploidy and Chromosomal Instability
University responsibilities
- Module Leader LS4001 Genes, Cells and Tissues 2025- Present
- Module Leader LS4014 Genes to Tissues 2025- Present