Dr Hossein Ashrafi

About

I received my PhD from Beatson Institute for Cancer Research, University of Glasgow in 1998 where I worked on viral causes of cancer. In the same year I was offered a postdoctoral fellowship in the Medical Oncology Laboratory at Glasgow University's Medical School, I was awarded a Royal Society Developing World Study Visit fellowship for distinguished postdoctoral work on relationship between papillomavirus and immune response.

I joined Kingston University, London in 2009 where I currently am an Associate Professor / Reader in Pathology, Course Leader for MSc Cancer Biology, fellow of Institute of Biomedical Science (IBMS), Fellow of Higher Education (FHEA). I teach on a range of Medical Science modules, supervise PhD research students, and lead an active research group on the interactions between the human host, viral pathogen and cancer, and also therapeutic approaches toward Human Papillomavirus (HPV) related cancers.

Academic responsibilities

Associate professor in Pathology/Cancer Biology

Qualifications

  • PhD in Pathology/Cancer Biology – Beatson Institute for Cancer Research, Faculty of Medicine, University of Glasgow
  • Postgraduate Certificate in Learning and Teaching in Higher Education, Kingston University London
  • DVM, University of Tehran. This is a professional doctorate degree together with one year research

Teaching and learning

Research

I have several goals to accomplish in the near future and some long term. I currently lead an active research programme with focus on the following subjects below:

1) Association of Human Papillomavirus (HPV) and breast and cervical cancers

2)Therapeutic approaches (using natural products) toward Human Papillomavirus (HPV) related cancers

3) Association of human papillomavirus (HPV) and urinary system cancers (prostate, bladder and renal) 

4) Mechanisms of host immunomodulation by Papillomavirus and Varizella-Zoster-Virus (VZV)

Research student supervision

Main supervision

Other supervision

Publications

Number of items: 39.

Article

Cakir, Muharrem Okan, Bilge, Ugur, Ghanbari, Arshia and Ashrafi, Hossein (2023) Regulatory effect of 'Ficus carica' latex on cell cycle progression in human papillomavirus-positive cervical cancer cell lines : insights from gene expression analysis. Pharmaceuticals, 16(12), p. 1723. ISSN (online) 1424-8247

Cakir, Muharrem Okan, Bilge, Ugur, Naughton, Declan and Ashrafi, G. Hossein (2023) 'Ficus carica' latex modulates immunity-linked gene expression in human papillomavirus positive cervical cancer cell lines : evidence from RNA seq transcriptome analysis. International Journal of Molecular Sciences, 24(17), p. 13646. ISSN (print) 1661-6596

Cakir, Muharrem Okan, Bilge, Ugur, Naughton, Declan and Ashrafi, Hossein (2023) 'Ficus carica' latex modulates immunity-linked gene expression in human papillomavirus positive cervical cancer cell lines: Evidence from RNA seq transcriptome analysis. International Journal of Molecular Sciences, 24(17), p. 13646. ISSN (print) 1661-6596

Ahmed, M. Yahya, Salman, Nadia Aziz, Sandhu, Sarbjinder, Cakir, M. Okan, Seddon, Alan M., Kuehne, Christian and Ashrafi, G. Hossein (2023) Detection of high-risk human papillomavirus in prostate cancer from a UK based population. Scientific Reports, 13(1), p. 7633. ISSN (online) 2045-2322

Motamed, Nima, Ajdarkosh, Hossein, Karbalaie Niya, Mohammad Hadi, Panahi, Mahshid, Farahani, Behzad, Rezaie, Nader, Nikkhah, Mehdi, Faraji, Amir H., Hemmasi, Gholamreza, Perumal, Dhayaneethie, Ashrafi, G. Hossein, Safarnezhad Tameshkel, Fahimeh, Gholizadeh, Esmaeel, Khoonsari, Mahmoodreza and Zamani, Farhad (2022) Scoring systems of metabolic syndrome and prediction of cardiovascular events : a population based cohort study. Clinical Cardiology, ISSN (print) 0160-9289 (Epub Ahead of Print)

Motamed, Nima, Nikkhah, Mehdi, Karbalaie Niya, Mohammad Hadi, khoonsari, Mahmoodreza, Perumal, Dhayaneethie, Ashrafi, G. Hossein, Faraji, Amir Hossein, Maadi, Mansooreh, Ajdarkosh, Hossein, Safarnezhad Tameshkel, Fahimeh, Moradi-Lakeh, Maziar, Miri, Seyyed Mohammad, Arsang-Jang, Shahram and Zamani, Farhad (2021) The ability of the Framingham Steatosis Index (FSI) to predict Non-alcoholic Fatty Liver Disease (NAFLD) : a cohort study. Clinics and Research in Hepatology and Gastroenterology, 45(6), p. 101567. ISSN (print) 2210-7401

Yadollahzadeh, Mahdi, Eskandari, Mohana, Roham, Maryam, Zamani, Farhad, Laali, Azadeh, Kalantari, Saeed, Yassin, Zeynab, Movahedi, Erfaneh, Farrokhpour, Mohsen, Zeiaei, Mohamad Taghei, Motamed, Nima, Aliakbar, Amirhossein, Soleimany, Fatemeh, Karampoor, Sajad, Ashrafi, Gholam Hossein, Safarnezhad Tameshkel, Fahimeh, Ranjbar, Mitra, Jamshidi Makiani, Mahin and Karbalaie Niya, Mohammad Hadi (2021) Evaluation of Sovodak (sofosbuvir/daclatasvir) treatment outcome in COVID-19 patients compared with Kaletra (lopinavir/ritonavir) ; a randomized clinical trial. Immunopathologia Persa, ISSN (online) 2423-8015 (Epub Ahead of Print)

Fattahi, Sadegh, Amjadi-Moheb, Fatemeh, Tabaripour, Reza, Ashrafi, Gholam Hossein and Akhavan-Niaki, Haleh (2020) PI3K/AKT/mTOR signaling in gastric cancer : epigenetics and beyond. Life sciences, 262, p. 118513. ISSN (print) 0024-3205

Tabibzadeh, Alireza, Tameshkel, Fahimeh Safarnezhad, Moradi, Yousef, Soltani, Saber, Moradi-Lakeh, Maziar, Ashrafi, G. Hossein, Motamed, Nima, Zamani, Farhad, Motevalian, Seyed Abbas, Panahi, Mahshid, Esghaei, Maryam, Ajdarkosh, Hossein, Mousavi-Jarrahi, Alireza and Niya, Mohammad Hadi Karbalaie (2020) Signal transduction pathway mutations in gastrointestinal (GI) cancers : a systematic review and meta-analysis. Scientific Reports, 10, p. 18713. ISSN (online) 2045-2322

Motamed, Nima, Ajdarkosh, Hossein, Ahmadi, Maral, Perumal, Dhayaneethie, Ashrafi, G Hossein, Nikkhah, Mehdi, Faraji, Amir Hossein, Maadi, Mansooreh, Khoonsari, Mahmoodreza, Rezaie, Nader, Farahani, Behzad, Safarnezhad Tameshkel, Fahimeh, Ameli, Mitra, Panahi, Mahshid, Karbalaie Niya, Mohammad Hadi and Zamani, Farhad (2020) Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event : a cohort study. World Journal of Hepatology, 12(6), pp. 323-331. ISSN (online) 1948-5182

Sher, Gulab, Salman, Nadia Aziz, Kulinski, Michal, Fadel, Rayyan Abdulaziz, Gupta, Vinod Kumar, Anand, Ambika, Gehani, Salahddin, Abayazeed, Sheraz, Al-Yahri, Omer, Shahid, Fakhar, Alshaibani, Salman, Hassan, Sara, Chawdhery, M. Zafar, Davies, Giles, Dermime, Said, Uddin, Shahab, Ashrafi, G. Hossein and Junejo, Kulsoom (2020) Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer : a Qatar based study. Cancers, 12(6), p. 1528. ISSN (online) 2072-6694

Yazdani, Zahra, Rafiei, Alireza, Valadan, Reza, Ashrafi, Hossein, Pasandi, MarziehSharifi and Kardan, Mostafa (2020) Designing a potent L1 protein-based HPV peptide vaccine : a bioinformatics approach. Computational Biology and Chemistry, 85, p. 107209. ISSN (print) 1476-9271

Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana and Ashrafi, G. Hossein (2019) Biological activities for 'Ficus carica' latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers. Scientific Reports, 9(1013), ISSN (online) 2045-2322

Fattahi, Sadegh, Golpour, Monireh, Amjadi-Moheb, Fatemeh, Sharifi-Pasandi, Marzieh, Khodadadi, Parastesh, Pilehchian-Langroudi, Maryam, Ashrafi, Gholam Hossein and Akhavan-Niaki, Haleh (2018) DNA methyltransferases and gastric cancer : insight into targeted therapy. Epigenomics, 10(11), pp. 1477-1497. ISSN (print) 1750-1911

Stanley, Aryan, Ashrafi, G. Hossein, Seddon, Alan M. and Modjtahedi, Helmout (2017) Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines. Scientific Reports, 7(3964), ISSN (online) 2045-2322

Salman, Nadia Aziz, Davies, Giles, Majidy, Farida, Shakir, Fatima, Akinrinade, Hilda, Perumal, Dhayaneethie and Ashrafi, G. Hossein (2017) Association of high risk human papillomavirus and breast cancer : a UK based study. Scientific Reports, 7, p. 43591. ISSN (online) 2045-2322

Amjadi, Omolbanin, Rafiei, Alireza, Haghshenas, Mohammadreza, Navaei, Reza Alizadeh, Valadan, Reza, Hosseini-Khah, Zahra, Omran, Akbar Hedayatizadeh, Arabi, Mohsen, Shakib, Reza Jafari, Mousavi, Tahoora and Ashrafi, G. Hossein (2017) A systematic review and meta-analysis of Seroprevalence of Varicella Zoster virus : a nationwide population-based study. Journal of Clinical Virology, 87, pp. 49-59. ISSN (print) 1386-6532

Motamed, Nima, Perumal, Dhaya, Zamani, Farhad, Ashrafi, Hossein, Haghjoo, Majid, Saeedian, F S, Maadi, Mansooreh, Akhavan-Niaki, Haleh, Rabiee, Behnam and Asouri, Mohsen (2015) Conicity index and waist-to-hip ratio are superior obesity indices in predicting 10-Year cardiovascular risk among men and women. Clinical Cardiology, 38(9), pp. 527-534. ISSN (print) 0160-9289

Ashrafi, Gholam Hossein and Perumal, Dhaya (2015) Human papillomavirus and cancer : immunological consequences of MHC Class I down-regulation. International Biological and Biomedical Journal, 1(1), pp. 1-7. ISSN (online) 2423-4478

Keyvani, Hossein, Sohrabi, Masoudreza, Zamani, Farhad, Poustchi, Hossein, Ashrafi, Hossein, Saeedian, Fatemeh, Mooadi, Mansooreh, Motamed, Nima, Ajdarkosh, Hossein, Khonsari, Mahmoodreza, Hemmasi, Gholamreza, Ameli, Mitra, Kabir, Ali and Khodadost, Mahmoud (2014) A population based study on hepatitis B virus in Northern Iran, Amol. Hepatitis Monthly, 14(8), e20540. ISSN (print) 1735-143X

Haghshenas, Mohammadreza, Golini-Moghaddam, Tahereh, Rafiei, Alireza, Emadeian, Omid, Shykhpour, Ahmad and Ashrafi, G Hossein (2013) Prevalence and type distribution of high-risk human papillomavirus in patients with cervical cancer: a population-based study. Infectious Agents and Cancer, 8(20), ISSN (online) 1750-9378

Campo, M.S., Graham, S.V., Cortese, M.S., Ashrafi, G.H., Araibi, E.H., Dornan, E.S., Miners, K., Nunes, C. and Man, S. (2010) HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells. Virology, 407(1), pp. 137-142. ISSN (print) 0042-6822

Barbaresi, S., Cortese, M. S., Quinn, J., Ashrafi, G. H., Graham, S. V. and Campo, M. S. (2010) Effects of human papillomavirus type 16 E5 deletion mutants on epithelial morphology: functional characterization of each transmembrane domain. Journal of General Virology, 91(2), pp. 521-530. ISSN (print) 0022-1317

Ashrafi, G. H., Grinfeld, Esther, Montague, Paul, Forster, Thorsten, Ross, Alan, Ghazal, Peter, Scott, Fiona, Breuer, Judith, Goodwin, Roslyn and Kennedy, Peter G. E. (2010) Assessment of transcriptomal analysis of varicella-zoster-virus gene expression in patients with and without post-herpetic neuralgia. Virus Genes, 41(2), pp. 192-201. ISSN (print) 0920-8569

Cortese, Marc S., Ashrafi, G. Hossein and Campo, M. Saveria (2010) All 4 di-leucine motifs in the first hydrophobic domain of the E5 oncoprotein of human papillomavirus type 16 are essential for surface MHC class I downregulation activity and E5 endomembrane localization. International Journal of Cancer, 126(7), pp. 1675-1682. ISSN (print) 0020-7136

Ashrafi, G. H., Piuko, K., Burden, F., Yuan, Z., Gault, E. A., Muller, M., Trawford, A., Reid, S. W. J., Nasir, L. and Campo, M. S. (2008) Vaccination of sarcoid-bearing donkeys with chimeric virus-like particles of bovine papillomavirus type 1. Journal of General Virology, 89(1), p. 148. ISSN (print) 0022-1317

Babamahmoodi, F, Aghabarari, F, Arjmand, A and Ashrafi, G (2006) Three rare cases of anthrax arising from the same source. Journal of Infection, 53(4), e175-e179. ISSN (print) 0163-4453

Ashrafi, G, Brown, D R, Fife, K and Campo, M (2006) Down-regulation of MHC class I is a property common to papillomavirus E5 proteins. Virus Research, 120(1-2), pp. 208-211. ISSN (print) 0168-1702

Araibi, E, Marchetti, B, Dornan, E. S., Ashrafi, G. H., Dobromylskyj, M, Ellis, S. A. and Campo, M. S. (2006) The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I. Virology, 353(1), pp. 174-183. ISSN (print) 0042-6822

Ashrafi, G. Hossein, Haghshenas, Mohammad, Marchetti, Barbara and Campo, M. Saveria (2006) E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chainvia its first hydrophobic domain. International Journal of Cancer, 119(9), pp. 2105-2122. ISSN (print) 0020-7136

Tsirimonaki, E, Ullah, R, Marchetti, B, Ashrafi, G, McGarry, L, Ozanne, B and Campo, M (2006) Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells. Virus Research, 115(2), pp. 158-168. ISSN (print) 0168-1702

Marchetti, B, Ashrafi, G. H., Dornan, E. S., Araibi, E. H., Ellis, S. A. and Campo, M. S. (2005) The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus. Oncogene, 25(15), pp. 2254-2263. ISSN (print) 0950-9232

Ashrafi, G. Hossein, Haghshenas, Mohammad R., Marchetti, Barbara, O'Brien, Philippa M. and Campo, M. Saveria (2005) E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I. International Journal of Cancer, 113(2), pp. 276-283. ISSN (print) 0020-7136

Araibi, E. H., Marchetti, B, Ashrafi, G.H. and Campo, M.S. (2004) Downregulation of major histocompatibility complex class I in bovine papillomas. Journal of General Virology, 85(10), pp. 2809-2814. ISSN (print) 0022-1317

Marchetti, Barbara, Ashrafi, G Hossein, Tsirimonaki, Emmanouella, O'Brien, Philippa M and Campo, M Saveria (2002) The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surface. Oncogene, 21(51), pp. 7808-7816. ISSN (print) 0950-9232

Ashrafi, G Hossein, Tsirimonaki, Emmanouella, Marchetti, Barbara, O'Brien, Philippa M, Sibbet, Gary J, Andrew, Linda and Campo, M Saveria (2002) Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins. Oncogene, 21(2), pp. 248-259. ISSN (print) 0950-9232

Ashrafi, G. Hossein, Pitts, John D, Faccini, AnnaMaria, McLean, Pauline, O’Brien, Vincent, Finbow, Malcolm E and Campo, Saveria (2000) Binding of bovine papillomavirus type 4 E8 to ductin (16K proteolipid), down-regulation of gap junction intercellular communication and full cell transformation are independent events. Journal of General Virology, 81(3), pp. 694-689. ISSN (print) 0022-1317

O'Brien, V, Ashrafi, G. H, Grindlay, G. Joan, Anderson, Ruth and Campo, M. Saveria (1999) A Mutational Analysis of the Transforming Functions of the E8 Protein of Bovine Papillomavirus Type 4. Virology, 255(2), pp. 385-394. ISSN (print) 0042-6822

Book Section

Ashrafi, G. Hossein and Salman, Nadia Aziz (2016) Pathogenesis of human papillomavirus : immunological responses to HPV infection. In: Rajkumar, Rajamanickam, (ed.) Human papillomavirus : research in a global perspective. Rijeka, Croatia : Intech. pp. 243-253. ISBN 9789535124399

This list was generated on Fri Nov 1 07:20:00 2024 GMT.