Dr Terry Gaymes

A Phase I trial of talazoparib in patients with advanced hematologic malignancies

Gopal, Ajay K, Popat, Rakesh, Mattison, Ryan J, Menne, Tobias, Bloor, Adrian, Gaymes, Terry, Khwaja, Asim, Juckett, Mark, Chen, Ying, Cotter, Matthew J and Mufti, Ghulam J, 2021, Arztliche Praxis Neurologie Psychiatrie (10), 3, Published

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FLT3 and JAK2 mutations in acute myeloid leukemia promote interchromosomal homologous recombination and the potential for copy neutral loss of heterozygosity

Mohamedali, Azim, Gaymes, Terry J., Eiliazadeh, Anthony L., Darling, David and Mufti, Ghulam J., 2017, Cancer Research (77), 7 pp 1697-1708, Published

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High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS)

Mohamedali, A M, Gaken, J, Ahmed, M, Malik, F, Smith, A E, Best, S, Mian, S, Gaymes, T, Ireland, R, Kulasekararaj, A G and Mufti, G J, 2015, Leukemia (29), 9 pp 1928-1938, Published

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PARP inhibitor sensitivity in high risk MDS and acute myeloid leukaemia is associated with microsatellite instability dependent frameshift mutations in DNA repair genes

Gaymes, Terry J., Mohamedali, Azim M., Patterson, Miranda, Matto, Nazia, Smith, Alexander, Kulasekaraj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney and Mufti, Ghulam J., 2013, Haematologica (98), 9 pp 1397-1406, Published

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Reducing MCM levels in human primary T cells during the G0-G1 transition causes genomic instability during the first cell cycle

Gaymes, T, Orr, S J, Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, G J, Marcotte, E M and Thomas, N S B, 2010, Oncogene (29), 26 pp 3803-3814, Published

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Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes

Shall, Sydney, MacPherson, Lee J., Twine, Natalie A., Lea, Nicholas C., Farzaneh, Farzin, Mufti, Ghulam J. and Gaymes, Terry J., 2009, Acta Haematologica (94) pp 638-646, Published

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Chromosomal instability syndromes are sensitive to Poly ADP-ribose polymerase inhibitors

Gaymes, Terry J., Shall, Sydney, Farzaneh, Farzin and Mufti, Ghulam J., 2008, Haematologica (93) pp 1886-1889, Published

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BCL6 mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a 53-dependent pathway in a cell-context dependent manner

Ranuncolo, Stella Maria, Wang, Ling, Polo, Jose M., Dell'Oso, Tania, Dierov, Jamil, Gaymes, Terry, Rassool, Feyruz, Carroll, Martin and Melnick, Ari, 2008, The Journal of Biological Chemistry (283), 33 pp 22565-22572, Accepted/In press

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Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?

Rassool, Feyruz, Gaymes, Terry J., Omidvar, Nader, Brady, Nicola, Buerlet, Stephanie, Pla, Marika, Reboul, Murielle, Lea, Nicholas, Chomienne, Christine, Thomas, Nicholas S.B., Mufti, Ghulam J. and Padua, Rose Ann, 2007, Cancer Research (67), 18 pp 8762-8771, Published

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Histone Deacetylase Inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?

Gaymes, Terry J., Padua, Rose Ann, Pla, Marika, Orr, Steven, Omidvar, Nader, Chomienne, Christine, Mufti, Ghulam J. and Rassool, Feyruz V., 2006, Molecular Cancer Research (4), 8 pp 563-573, Published

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Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins

Brady, Nicola, Gaymes, Terry J., Cheung, Manyee, Mufti, Ghulam J. and Rassool, Feyruz V., 2003, Cancer Research (63), 8 pp 1798-1805, Published

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Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer

Gaymes, Terry J., Mufti, Ghulam J. and Rassool, Feyruz V., 2002, Cancer Research (62), 10 pp 2791-2797, Published

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Increased error-prone non homologous DNA end-joining - a proposed mechanism of chromosomal instability in Bloom's Syndrome

Gaymes, Terry J, North, Phillip S, Brady, Nicola, Hickson, Ian D, Mufti, Ghulam J and Rassool, Feyruz, 2001, Oncogene (21) pp 2525-2533, Published

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Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation

Cebrat, Marek, Siemion, Ignacy Z, Gaymes, Terry J and Kay, John E, 1997, FEBS Letters (418), 1-2 pp 224-227, Published

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The use of PARP inhibitors in cancer therapy: use as adjuvant with chemotherapy or radiotherapy ; use as a single agent in susceptible patients ; techniques used to identify susceptible patients

Shall, Sydney, Gaymes, Terry, Farzaneh, Farzin, Curtin, Nicola and Mufti, Ghulam J. (2011). In: Tulin, Alexei V., (eds.), New York, NY: Springer pp 239-266 [Published]

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Effects of cyclolinopeptide A on T lymphocyte activation and peptidyl prolyl isomerase activity

Gaymes, Terry, Carrett, Neil, Patel, Nishith, Kay, John and Siemion, Iggy(1995). [Published]

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