Dr Natasha Hill

About

I graduated from Bristol University with a degree in Biochemistry before completing a PhD in the Genetics of Type 1 diabetes at Oxford under the supervision of Prof John Todd. I then moved to the USA to work with Dr Nora Sarvetnick at The Scripps Research Institute in La Jolla, investigating the regulation of autoimmunity by a particular gene variant in the non-obese diabetic (NOD) model of type 1 diabetes. I returned to the UK and worked briefly as an independent research fellow at the Blizard Institute (part of Barts and The London) before obtaining a permanent position at Kingston University in 2008. My current research is focused on finding novel approaches to promote islet regeneration, and my lab also has an interest in pancreatic cancer. I lead the Diabetes and Cardiovascular Research Group (DCRG) within the IhSHA Research Centre.

Academic responsibilities

Associate professor

Qualifications

  • BSc Hons
  • PhD
  • SF-HEA

Teaching and learning

I teach genetics and molecular biology at undergraduate and postgraduate level, and am module leader for the level 5 module 'Molecular Biology of the Cell'.

Undergraduate courses taught

Postgraduate courses taught

Research

Research overview

Current projects in my group include: using a decellularised pancreas matrix to support stem cell differentiation into insulin-producing beta cells, the role of matricellular proteins in islet regeneration and pancreatic cancer, and the expression of alternative transcripts in disease.

I lead the Diabetes and Cardiovascular Research Group (DCRG) within the IhSHA Research Centre:

http://sec.kingston.ac.uk/research/research-groups/drg/

We are very grateful to the following for funding current research in our laboratory:

  • Diabetes UK - https://www.diabetes.org.uk/
  • Society for Endocrinology - https://www.endocrinology.org/
  • Kingston Hospital Charity - https://www.khc.org.uk/

Current research team:

  • Amanda Munasinghe (Diabetes UK funded postdoc)
  • Amtul Bhunnoo (PhD student)
  • Fatemia Mohamedi (PhD student)
  • Cris Barra Domingos (PhD student)
  • Khalisha Malik (MScR student)

I am also co-supervisor for a further 4 PhD students and 1 MScR student.

I have previously successfully supervised 8 PhD students (5 as first supervisor) and 7 MSc by Research students (all as first supervisor) to completion.

Research student supervision

Main supervision

Other supervision

Publications

Number of items: 33.

Article

Hewawasam, Nirun, Lhaf, Fadel, Taylor, Henry A, Viloria, Katrina, Austin, Amazon, King, Aileen, Jones, Peter, Jones, Lucy, Turner, Mark D and Hill, Natasha (2020) Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress. Scientific Reports, 10, p. 15741. ISSN (online) 2045-2322

Munasinghe, Amanda, Malik, Khalisha, Mohamedi, Fatemia, Moaraf, Stan, Kocher, Hemant, Jones, Lucy and Hill, Natasha J. (2020) Fibronectin acts as a molecular switch to determine SPARC function in pancreatic cancer. Cancer Letters, 477, pp. 88-96. ISSN (print) 0304-3835

Benedetti, Simone, Al-Tannak, Naser F., Alzharani, Mansour, Moir, Hannah J., Stensel, David J., Thackray, Alice E., Naughton, Declan, Dorak, Mehmet T., Spendiff, Owen, Hill, Natasha, Watson, David G. and Allgrove, Judith (2019) Plasma free fatty acids metabolic profile with LC-MS and appetite-related hormones in South Asian and White European men in relation to adiposity, physical activity and cardiorespiratory fitness : a cross-sectional study. Metabolites, 9(4), p. 71. ISSN (online) 2218-1989

Funnell, Gillian, Naicker, Kevin, Chang, John, Hill, Natasha and Kayyali, Reem (2018) A cross-sectional survey investigating women's information sources, behaviour, expectations, knowledge and level of satisfaction on advice received about diet and supplements before and during pregnancy. BMC Pregnancy and Childbirth, 18, p. 182. ISSN (online) 1471-2393

Kazantzidis, Ioannis, Florez-Revuelta, Francisco, Dequidt, Maickael, Hill, Natasha and Nebel, Jean-Christophe (2018) Vide-omics : a genomics-inspired paradigm for video analysis. Computer Vision and Image Understanding, 166, pp. 28-40. ISSN (print) 1077-3142

Viloria, Katrina, Munasinghe, Amanda, Asher, Sharan, Bogyere, Roberto, Jones, Lucy and Hill, Natasha (2016) A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth. Scientific Reports, 6, p. 37839. ISSN (online) 2045-2322

Hill, Natasha, Denholm-Price, James, Atkins, Nigel, Tojal Dourado, Luis, Nimoh, Owuraku and Page, Nigel (2016) Does group assessment impact BME attainment? New Directions in the Teaching of Physics, 11(1), ISSN (online) 2051-3615

Viloria, Katrina and Hill, Natasha J. (2016) Embracing the complexity of matricellular proteins : the functional and clinical significance of splice variation. Biomolecular Concepts, 7(2), pp. 117-132. ISSN (print) 1868-5021

Ryall, Claire, Viloria, Katrina, Lhaf, Fadel, Walker, Anthony J., King, Aileen, Jones, Peter, Mackintosh, David, Mcniece, Rosemary, Kocher, Hemant, Flodstrom-Tullberg, Malin, Edling, Charlotte and Hill, Natasha (2014) Novel role for matricellular proteins in the regulation of islet [beta] cell survival : the effect of SPARC on survival, proliferation and signalling. The Journal of Biological Chemistry, 289, pp. 30614-30624. ISSN (print) 0021-9258

McGuire, Helen M., Vogelzang, Alexis, Hill, Natasha, Flodstrom-Tullberg, Malin, Sprent, Jonathan and King, Cecile (2009) Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proceedings of the National Academy of Sciences, 106(46), pp. 19438-19443. ISSN (print) 0027-8424

Yadav, Deepak, Hill, Natasha, Yagita, Hideo, Azuma, Miyuki and Sarvetnick, Nora (2009) Altered availability of PD-1/PD ligands is associated with the failure to control autoimmunity in NOD mice. Cellular Immunology, 258(2), pp. 161-171. ISSN (print) 0008-8749

Hultcrantz, M., Jacobson, S., Hill, N. J., Santamaria, P. and Flodström-Tullberg, M. (2009) The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice. Diabetologia, 52(2), pp. 299-305. ISSN (print) 0012-186X

Hill, Natasha J., King, Cecile and Flodstrom-Tullberg, Malin (2008) Recent acquisitions on the genetic basis of autoimmune disease. Frontiers in Bioscience, 13(13), pp. 4838-4851. ISSN (print) 1093-9946

Hill, NJ, Stotland, AB and Sarvetnick, NE (2007) Distinct regulation of autoreactive CD4 T cell expansion by interleukin-4 under conditions of lymphopenia. Journal of Leukocyte Biology, 81, pp. 757-765. ISSN (print) 0741-5400

Hill, Natasha J., Hultcranz, Monica, Sarvetnick, Nora and Flodstrom-Tullberg, Malin (2007) The target tissue in autoimmunity : an influential niche. European Journal of Immunology, ISSN (print) 0014-2980

Hill, Natasha J, Stotland, Aleksander, Solomon, Michelle, Secrest, Patrick, Getzoff, Elizabeth and Sarvetnick, Nora (2007) Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes. Biology Direct, 2, p. 5. ISSN (online) 1745-6150

Hill, Natasha J., Van Gunst, Kurt and Sarvetnick, Nora (2003) Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice. The Journal of Immunology, 170(4), pp. 1649-1658. ISSN (print) 0022-1767

Hill, Natasha and Sarvetnick, Nora (2002) Cytokines: promoters and dampeners of autoimmunity. Current Opinion in Immunology, 14(6), pp. 791-797. ISSN (print) 0952-7915

Cordell, Heather J., Todd, John A., Hill, Natasha J., Lord, Christopher J., Lyons, Paul A., Peterson, Laurence B., Wicker, Linda S. and Clayton, David G. (2001) Statistical modelling of inter-locus interactions in a complex disease : rejection of the multiplicative model of epistasis in type 1 diabetes. Genetics, 158(1), pp. 357-367. ISSN (print) 0016-6731

Hill, N J, Lyons, P A, Armitage, N, Todd, J A, Wicker, L S and Peterson, L B (2000) The NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes, 49(10), pp. 1744-1747. ISSN (print) 0012-1797

Lyons, Paul A, Hancock, Wayne W, Denny, Paul, Lord, Christopher J, Hill, Natasha J, Armitage, Nicola, Siegmund, Thorsten, Todd, John A, Phillips, Michael S, Hess, J Fred, Chen, Shiow-Ling, Fischer, Paul A, Peterson, Laurence B and Wicker, Linda S (2000) The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. Immunity, 13(1), pp. 107-115. ISSN (print) 1074-7613

Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., Wilusz, Mary Beth, Peterson, Laurence B., Wicker, Linda S. and Todd, John A. (2000) Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3 : identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Research, 10(4), pp. 446-453. ISSN (print) 1088-9051

Esposito, Laura, Hill, Natasha J., Pritchard, Lynn E., Cucca, Francesco, Muxworthy, Claire, Merriman, Marilyn E., Wilson, Amanda, Julier, Cecile, Delepine, Mark, Tuomilehto, Jaako, Tuomilehto-Wolf, Eva, Ionesco-Tirgoviste, Constantin, Nistico', Lorenza, the IMDIAB Group, Buzzetti, Raffaela, Pozzilli, Paolo, Ferrari, Maurizio, Bosi, Emanuele, Pociot, Flemming, Nerup, Jorn, Bain, Stephen C. and Todd, John A. (1998) Genetic analysis of Chromosome 2 in type 1 diabetes : analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. Diabetes, 47(11), pp. 1797-1799. ISSN (print) 0012-1797

Podolin, P. L., Denny, P., Armitage, N., Lord, C. J., Hill, N. J., Levy, E. R., Peterson, L. B., Todd, J. A., Wicker, L. S. and Lyons, P. A. (1998) Localisation of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3. Mammalian Genome, 9(4), pp. 283-286. ISSN (print) 0938-8990

Podolin, P L, Denny, P, Lord, C J, Hill, N J, Todd, J A, Peterson, L B, Wicker, L S and Lyons, P A (1997) Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10 localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1. The Journal of Immunology, 159(4), pp. 1835-1843. ISSN (print) 0022-1767

Denny, Paul, Lord, Christopher J, Hill, Natasha J, Goy, Juliet V Goy, Levy, Elaine R, Podolin, Patricia L, Peterson, Laurence B, Wicker, Linda S, Todd, John A and Lyons, Paul A (1997) Mapping of the insulin-dependent diabetes locus Idd3 to a 0.35cM interval containing the Interleukin-2 gene. Diabetes, 46(4), pp. 695-700. ISSN (print) 0012-1797

Lord, C. J., Bohlander, S. K., Hopes, E. A., Montague, C. T., Hill, N. J., Prins, J.-B., Peterson, L. B., Wicker, L. S., Todd, J. A. and Denny, P. (1995) Mapping of the diabetes polygene Idd3 on mouse Chromosome 3 using novel congenic strains. Mammalian Genome, 6(9), pp. 563-570. ISSN (print) 0938-8990

Conference or Workshop Item

Page, Nigel, Hughes, Annie, Hill, Natasha and Denholm-Price, James (2018) Creating inclusive assessment practices in the age of the commuting student. In: Simply Better : Researching Assessment Practices – Improving Student Outcomes; 13 Sep 2018, Southampton, U.K..

Page, Nigel, Usman, Salman, Denholm-Price, James, Eastwood, Jonathan and Hill, Natasha (2018) Developing more inclusive and fairer assessment practices in relationship to group work in the biosciences. In: Evolving molecular bioscience education; 12-13 Apr 2018, Chester, U.K.. (Unpublished)

Benedetti, Simone, Moir, Hannah, Naughton, Declan, Hill, Natasha, Stensel, David, Thackray, Alice and Allgrove, Judith (2018) Physical activity, and risk factors for Diabetes and Cardiovascular disease in South Asian and European men. In: Diabetes UK Professional Conference 2018; 14 -18 Mar 2018, London, U.K.. (In Press)

Hill, Natasha, Denholm-Price, James, Page, Nigel, Atkins, Nigel, Dourado, Luis, Forty, Cass and Nimoh, Owuraku (2016) Can group assessments enhance BME attainment? In: Horizons in STEM Higher Education Conference 2016: Making Connections and Sharing Pedagogy; 30 Jun - 01 Jul 2016, Leicester, U.K.. (Unpublished)

Viloria, Katrina, Ryall, Claire, Dandagama Mudiyanselage, Amanda, Asher, Sharan, Lhaf, Fadel, King, Aileen, Jones, Peter, Kocher, Hermant, Jones, Lucy and Hill, Natasha (2015) Creating a 3D matricellular environment to promote islet expansion for diabetes therapy – the role of SPARC family proteins. In: Experimental Biology 2015; 28 Mar - 01 Apr 2015, Boston, U.S.. (Unpublished)

Lhaf, F, Taylor, H, Austin, ALF, King, A, Jones, P, Turner, M, Jones, L and Hill, N (2015) Modulation of growth factor receptor trafficking as a novel approach to promoting beta cell expansion. In: Diabetes UK Professional Conference 2015 : Diabetes: time to take control; 11 - 13 Mar 2015, London, U.K..

This list was generated on Fri Nov 27 06:46:27 2020 GMT.

Videos of my work