Dr Francesca Mackenzie

Faculty of Health, Science, Social Care and Education
Department of Chemical and Pharmaceutical Sciences
School of Life Sciences, Pharmacy and Chemistry
Penrhyn Road

Senior Lecturer in Physiology and Pharmacology (Neuroscience)

[email protected]

ORCID

About

I am a Senior Lecturer in Physiology and Pharmacology, with a specialism in neuroscience. I teach undergraduate neurophysiology and neuropharmacology. I am also the Deputy Course Leader for BSc Pharmacology, and I lead a small research group of postgraduate students.

My subject research interests are in the genetics and cell biology of neuronal development and regeneration, particularly in the peripheral nervous system and in the eye. My pedagogical interests are in research-led teaching, embedding authentic problem-solving, and in equality, diversity and inclusivity.

I obtained my PhD on the genetics and pathophysiology of deafness from University of Oxford and MRC Harwell Mammalian Genetics Unit. During postdoctoral work I then researched neuromuscular biology at MRC Harwell, and neuronal development, regeneration and degeneration at UCL Institute of Ophthalmology.

My work falls under the UN Sustainable Development Goals of 3 Good Health and Wellbeing, 4 Quality Education, and 10 Reduced Inequalities.

Qualifications

Fellow of the Higher Education Academy (FHEA)
Associate Fellow of the Higher Education Academy (AFHEA)
DPhil (Oxon) Genetics, University of Oxford
BSc (Hons) Applied Biology, University of Bath

Domains

Publications

Metabolites of cannabis induce cardiac toxicity and morphological alterations in cardiac myocytes

Merve, Ayse Orme, Sobiecka, Pola, Remeškevičius, Vytautas, Taylor, Luke, Saskoy, Lili, Lawton, Scott, Jones, Ben P., Elwakeel, Ahmed, Mackenzie, Francesca E., Polycarpou, Elena, Bennett, Jason and Rooney, Brian, 2022, International Journal of Molecular Sciences (23), 3, Published

View this article

Mechanosensing and the Hippo pathway in microglia: a potential link to Alzheimer's disease pathogenesis

Bruno, Lucrezia, Karagil, Simge, Mahmood, Almas, Elbediwy, Ahmed, Stolinski, Michael and Mackenzie, Francesca E., 2021, Cells (10), 11, Published

View this article

Dysfunctional mechanotransduction through the YAP/TAZ/Hippo pathway as a feature of chronic disease

Cobbaut, Mathias, Karagil, Simge, Bruno, Lucrezia, Diaz de la Loza, Maria Del Carmen, Mackenzie, Francesca E., Stolinski, Michael and Elbediwy, Ahmed, 2020, Cells (9), 1, Published

View this article

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A., South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M., Kanuga, Naheed, Mackenzie, Francesca E., Dubis, Adam M., Georgiadis, Anastasios, Graca, Anna B., Pearson, Rachael A., Ali, Robin R., Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y., Reeves, Philip J. and Cheetham, Michael E., 2017, Human Molecular Genetics (26), 2 pp 305-319, Published

View this article

Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves

Cattin, Anne Laure, Burden, Jemima J., Van Emmenis, Lucie, MacKenzie, Francesca E., Hoving, Julian J.A., Garcia Calavia, Noelia, Guo, Yanping, McLaughlin, Maeve, Rosenberg, Laura H., Quereda, Victor, Jamecna, Denisa, Napoli, Ilaria, Parrinello, Simona, Enver, Tariq, Ruhrberg, Christiana and Lloyd, Alison C., 2015, Cell (162), 5 pp 1127-1139, Published

View this article

Neural crest cell-derived VEGF promotes embryonic jaw extension

Wiszniak, Sophie, Mackenzie, Francesca E., Anderson, Peter, Kabbara, Samuela, Ruhrberg, Christiana and Schwarz, Quenten, 2015, Proceedings of the National Academy of Sciences of the United States of America (112), 19 pp 6086-6091, Published

View this article

Diverse roles for VEGF-A in the nervous system

Mackenzie, Francesca and Ruhrberg, Christiana, 2012, Development (Cambridge) (139), 8 pp 1371-1380, Published

View this article

Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity

Tillo, Miguel, Ruhrberg, Christiana and Mackenzie, Francesca, 2012, Cell Adhesion & Migration (6), 6 pp 541-546, Published

View this article

Axonal and neuromuscular synaptic phenotypes in WldS, SOD1G93A and ostes mutant mice identified by fiber-optic confocal microendoscopy

Wong, Frances, Fan, Li, Wells, Sara, Hartley, Robert, Mackenzie, Francesca E., Oyebode, Oyinlola, Brown, Rosalind, Thomson, Derek, Coleman, Michael P., Blanco, Gonzalo and Ribchester, Richard R., 2009, Molecular and Cellular Neuroscience (42), 4 pp 296-307, Published

S, SOD1G93A and ostes mutant mice identified by fiber-optic confocal microendoscopy">View this article

Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss

MacKenzie, F. E., Parker, A., Parkinson, N. J., Oliver, P. L., Brooker, D., Underhill, P., Lukashkina, V. A., Lukashkin, A. N., Holmes, C. and Brown, S. D. M., 2009, Genes, Brain and Behavior (8), 7 pp 699-713, Published

View this article

Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse

Mackenzie, Francesca, Romero, Rosario, Williams, Debbie, Gillingwater, Thomas, Hilton, Helen, Dick, Jim, Riddoch-Contreras, Joanna, Wong, Frances, Ireson, Lisa, Powles-Glover, Nicola, Riley, Genna, Underhill, Peter, Hough, Tertius, Arkell, Ruth, Greensmith, Linda, Ribchester, Richard R. and Blanco, Gonzalo, 2009, Human Molecular Genetics (18), 19 pp 3553-3566, Published

View this article

Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media

Parkinson, Nicholas, Hardisty-Hughes, Rachel E., Tateossian, Hilda, Tsai, Hsun Tien, Brooker, Debra, Morse, Sue, Lalane, Zuzanna, MacKenzie, Francesca, Fray, Martin, Glenister, Pete, Woodward, Anne Marie, Polley, Sian, Barbaric, Ivana, Dear, Neil, Hough, Tertius A., Hunter, A. Jackie, Cheeseman, Michael T. and Brown, Steve D.M., 2006, PLoS Genetics (2), 10 pp 1556-1564, Published

View this article

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

Charalambous, Marika, Smith, Florentia M., Bennett, William R., Crew, Tracey E., Mackenzie, Francesca and Ward, Andrew, 2003, Proceedings of the National Academy of Sciences of the United States of America (100), 14 pp 8292-8297, Published

View this article